WorldCat Identities

Hille, Bertil 1940-

Overview
Works: 15 works in 74 publications in 2 languages and 1,755 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Editor, Other, Opponent
Publication Timeline
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Most widely held works by Bertil Hille
Ionic channels of excitable membranes by Bertil Hille( Book )

49 editions published between 1984 and 2007 in English and held by 1,396 WorldCat member libraries worldwide

DSU Title III 2007-2012
Proteins of excitable membranes( Book )

10 editions published in 1987 in English and held by 229 WorldCat member libraries worldwide

Ion channels of excitable membranes by Bertil Hille( Book )

1 edition published in 2001 in English and held by 113 WorldCat member libraries worldwide

A pharmacological analysis of the ionic channels of nerve by Bertil Hille( )

3 editions published between 1967 and 1970 in English and held by 6 WorldCat member libraries worldwide

Trattato di fisiologia( Book )

1 edition published in 1991 in Italian and held by 2 WorldCat member libraries worldwide

Textbook of physiology( Book )

1 edition published in 1989 in English and held by 1 WorldCat member library worldwide

Noradrenaline upregulates T-type calcium channels in rat pinealocytes( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Proteins of excitable membranes : Symposium : Papers by Proteins of excitable membranes( Book )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Pertussis toxin and voltage dependence distinguish multiple pathways modulating calcium channels of rat sympathetic neurons by David J Beech( )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Molecular Mechanisms of Resin Acids and Their Derivatives on the Opening of a Potassium Channel by Nina Ottosson( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Voltage-gated ion channels play fundamental roles in excitable cells, such as neurons, where they enable electric signaling. Normally, this signaling is well controlled, but brain damage, alterations in the ionic composition of the extracellular solution, or dysfunctional ion channels can increase the electrical excitability thereby causing epilepsy. Voltage-gated ion channels are obvious targets for antiepileptic drugs, and, as a rule of thumb, excitability is dampened either by closing voltagegated sodium channels (Nav channels) or by opening voltage-gated potassium channels (Kv channels). For example, several classical antiepileptic drugs block the ion-conducting pore of Nav channels. Despite the large number of existing antiepileptic drugs, one third of the patients with epilepsy suffer from intractable or pharmacoresistant seizures. Our research group has earlier described how different polyunsaturated fatty acids (PUFAs) open a Kv channel by binding close to the voltage sensor and, from this position, electrostatically facilitate the movement of the voltage-sensor, thereby opening the channel. However, PUFAs affect a wide range of ion channels, making it difficult to use them as pharmaceutical drugs; it would be desirable to find smallmolecule compounds with an electrostatic, PUFA-like mechanism of action. The aim of the research leading to this thesis was to find, characterize, and refine drug candidates capable of electrostatically opening a Kv channel. The majority of the experiments were performed on the cloned Shaker Kv channel, expressed in oocytes from the frog Xenopus laevis, and the channel activity was explored with the two-electrode voltage-clamp technique. By systematically mutating the extracellular end of the channel's voltage sensor, we constructed a highly PUFAsensitive channel, called the 3R channel. Such a channel is a useful tool in the search for electrostatic Kv-channel openers. We found that resin acids, naturally occurring in tree resins, act as electrostatic Shaker Kv channel openers. To explore the structure-activity relationship in detail, we synthesized 120 derivatives, whereof several were potent Shaker Kv channel openers. We mapped a common resin acidbinding site to a pocket formed by the voltage sensor, the channel's third transmembrane segment, and the lipid membrane, a principally new binding site for small-molecule compounds. Further experiments showed that there are specific interactions between the compounds and the channel, suggesting promises for further drug development. Several of the most potent Shaker Kv channel openers also dampened the excitability in dorsal-root-ganglion neurons from mice, elucidating the pharmacological potency of these compounds. In conclusion, we have found that resin-acid derivatives are robust Kv-channel openers and potential drug candidates against diseases caused by hyperexcitability, such as epilepsy
Characterization of muscarinic receptor subtypes inhibiting Ca²+ current and M current in rat sympathetic neurons by Laurent Bernheim( )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Signalling mechanisms( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Inonic Channels of excitable membranes by Bertil Hille( Book )

1 edition published in 1984 in English and held by 1 WorldCat member library worldwide

Inhibition of N- and L-type calcium channels by muscarinic receptor activation in rat sympathetic neurons by A Mathie( )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Signalling mechanisms( Book )

1 edition published in 1995 in English and held by 0 WorldCat member libraries worldwide

 
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Ion channels of excitable membranes
Covers
Ion channels of excitable membranes
Alternative Names
Bertil Hille ahli biologi asal Amerika Serikat

Bertil Hille Amerikaans bioloog

Bertil Hille nolavan Lamerikänik

Bertil Hille US-amerikanischer Biologe

Bertil Hille usona sciencisto

Hille B.

伯蒂尔·希勒

Languages