WorldCat Identities

Panula, Pertti 1952-

Works: 16 works in 31 publications in 2 languages and 300 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Editor, Opponent, 958, Contributor, Other
Publication Timeline
Most widely held works by Pertti Panula
Neurohistochemistry, modern methods and applications( Book )

9 editions published between 1985 and 1986 in English and held by 195 WorldCat member libraries worldwide

Histamine in the Brain by Maria Beatrice Passani( )

3 editions published in 2015 in English and held by 80 WorldCat member libraries worldwide

Brain aminergic pathways are organized in parallel and interacting systems, which support a range of functions, from homoeostatic regulations to cognitive, and motivational processes. Despite overlapping functional influences, dopamine, serotonin, noradrenaline and histamine systems provide different contributions to these processes. The histaminergic system, long ignored as a major regulator of the sleep-wake cycle, has now been fully acknowledged also as a major coordinator of attention, learning and memory, decision making. Although histaminergic neurons project widely to the whole brain, they are functionally heterogeneous, a feature which may provide the substrate for differential regulation, in a region-specific manner, of other neurotransmitter systems. Neurochemical preclinical studies have clearly shown that histamine interacts and modulates the release of neurotransmitters that are recognized as major modulators of cognitive processing and motivated behaviours. As a consequence, the histamine system has been proposed as a therapeutic target to treat sleep-wake disorders and cognitive dysfunctions that accompany neurodegenerative and neuroinflammatory pathologies. Last decades have witnessed an unexpected explosion of interest in brain histamine system, as new receptors have been discovered and selective ligands synthesised. Nevertheless, the complete picture of the histamine systems fine-tuning and its orchestration with other pathways remains rather elusive. This Research Topic is intended to offer an inter-disciplinary forum that will improve our current understanding of the role of brain histamine and provide the fundamentals necessary to drive innovation in clinical practice and to improve the management and treatment of neurological disorders
A light and electron microscopical and histochemical study on the rat neostriatum in vivo and in vitro by Pertti Panula( Book )

4 editions published in 1980 in English and held by 8 WorldCat member libraries worldwide

Abstracts of the VIIth International Congress of Histochemistry and Cytochemistry, August 5-11, 1984, Helsinki, Finland by International Congress of Histochemistry and Cytochemistry( Book )

2 editions published in 1984 in English and held by 3 WorldCat member libraries worldwide

Neurochemistry : modern methods and applications( Book )

1 edition published in 1986 in English and held by 3 WorldCat member libraries worldwide

Lintujensuojelun opas by Seppo Karhu( Book )

2 editions published in 1971 in Finnish and held by 2 WorldCat member libraries worldwide

Artificial Selection on Relative Brain Size Reveals a Positive Genetic Correlation Between Brain Size and Proactive Personality in the Guppy by Alexander Kotrschal( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Animal personalities range from individuals that are shy, cautious, and easily stressed (a "reactive" personality type) to individuals that are bold, innovative, and quick to learn novel tasks, but also prone to routine formation (a "proactive" personality type). Although personality differences should have important consequences for fitness, their underlying mechanisms remain poorly understood. Here, we investigated how genetic variation in brain size affects personality. We put selection lines of large- and small-brained guppies (Poecilia reticulata), with known differences in cognitive ability, through three standard personality assays. First, we found that large-brained animals were faster to habituate to, and more exploratory in, open field tests. Large-brained females were also bolder. Second, large-brained animals excreted less cortisol in a stressful situation (confinement). Third, large-brained animals were slower to feed from a novel food source, which we interpret as being caused by reduced behavioral flexibility rather than lack of innovation in the large-brained lines. Overall, the results point toward a more proactive personality type in large-brained animals. Thus, this study provides the first experimental evidence linking brain size and personality, an interaction that may affect important fitness-related aspects of ecology such as dispersal and niche exploration
Plasticity of histamine H3 receptor expression and binding in the vestibular nuclei after labyrinthectomy in rat( )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

Knockout of histamine receptor H3 alters adaptation to sudden darkness and monoamine levels in the zebrafish( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: Aim: Histamine receptor H3 (HRH3) has substantial neuropharmacological potential. Currently, knockout models of this receptor have been investigated only in mice. We characterized the expression of this receptor in the zebrafish and generated a zebrafish HRH3 knockout line. Using this model, we studied the role of HRH3 in important behaviours. We also analysed the effect of HRH3 knockout on monoaminergic systems, which has not been thoroughly studied in any animal model. Methods: Generation of a mutant zebrafish line using the CRISPR‐Cas9 system. Analysis of locomotor and social behaviour. Expression of HRH3 was characterized using insitu hybridization. Analysis of monoamine networks using HPLC, immunohistochemistry and quantitative PCR. Results: We found that HRH3 knockout zebrafish larvae showed a shorter period of increased locomotion after a sudden onset of darkness, while the knockout larvae had a wild‐type‐like acute response to sudden darkness. Adult knockout fish showed decreased swimming velocity, although locomotor activity of knockout larvae was unaltered. Additionally, levels of dopamine and serotonin were significantly decreased in the knockout fish, while monoamine‐related gene expression and immunohistochemistry patterns were unchanged. Conclusions: Our results show that HRH3 knockout larvae adapt faster to sudden darkness, suggesting a role for this receptor in regulating responses to changes in the environment. The decreased levels of dopamine and serotonin provide the first direct evidence that knockout of HRH3 alters these systems
Histamine H3 receptor antagonist decreases cue-induced alcohol reinstatement in mice( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: We have earlier found that the histamine H3 receptor (H3R) antagonism diminishes motivational aspects of alcohol reinforcement in mice. Here we studied the role of H3Rs in cue-induced reinstatement of alcohol seeking in C57BL/6 J mice using two different H3R antagonists. Systemic administration of H3R antagonists attenuated cue-induced alcohol seeking suggesting that H3R antagonists may reduce alcohol craving. To understand how alcohol affects dopamine and histamine release, a microdialysis study was performed on C57BL/6 J mice and the levels of histamine, dopamine and dopamine metabolites were measured in the nucleus accumbens. Alcohol administration was combined with an H3R antagonist pretreatment to reveal whether modulation of H3R affects the effects of alcohol on neurotransmitter release. Alcohol significantly increased the release of dopamine in the nucleus accumbens but did not affect histamine release. Pretreatment with H3R antagonist ciproxifan did not modify the effect of alcohol on dopamine release. However, histamine release was markedly increased with ciproxifan. In conclusion, our findings demonstrate that H3R antagonism attenuates cue-induced reinstatement of alcohol seeking in mice. Alcohol alone does not affect histamine release in the nucleus accumbens but H3R antagonist instead increases histamine release significantly suggesting that the mechanism by which H3R antagonist inhibits alcohol seeking found in the present study and the decreased alcohol reinforcement, reward and consumption found earlier might include alterations in the histaminergic neurotransmission in the nucleus accumbens. These findings imply that selective antagonists of H3Rs could be a therapeutic strategy to prevent relapse and possibly diminish craving to alcohol use. This article is part of the Special Issue entitled 'Histamine Receptors'. Highlights: Operant oral alcohol administration paradigm in mice was established in this study. Operant responding was reinstated by cues associated with alcohol administration. Histamine H3 receptor antagonists inhibited cue-induced reinstatement of alcohol seeking. Alcohol did not affect histamine release in nucleus accumbens. H3 receptor antagonist increased histamine but not dopamine release in nucleus accumbens
Lintujen pesäpöntöt ja suojelu by Seppo Karhu( Book )

1 edition published in 1983 in Finnish and held by 1 WorldCat member library worldwide

Histamine receptors( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Interactions of the orexin/hypocretin neurones and the histaminergic system( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Abstract Histaminergic and orexin/hypocretin systems are components in the brain wake‐promoting system. Both are affected in the sleep disorder narcolepsy, but the role of histamine in narcolepsy is unclear. The histaminergic neurones are activated by the orexin/hypocretin system in rodents, and the development of the orexin/hypocretin neurones is bidirectionally regulated by the histaminergic system in zebrafish. This review summarizes the current knowledge of the interactions of these two systems in normal and pathological conditions in humans and different animal models
Functional analysis of the ADHD-susceptibility gene lphn3.1 in zebrafish by Merlin Lange( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Attention-Deficit/Hyperactivity Disorder (ADHD; MIM#143465) is a common, early onset and enduring neuropsychiatric disorder characterized by developmentally inappropriate inattention, hyperactivity, increased impulsivity and motivational dysregulation. In collaboration with Prof. Klaus-Peter Lesch, psychiatrist at the University of Würzburg (Germany), we aimed to validate the ADHD susceptibility gene Latrophilin 3 (Lphn3) in disease formation. LPHN3 had been linked with ADHD in genetic association studies on ADHD patients, followed by fine locus mapping (Arcos-Burgos et al., 2010). The endogenous function of LPHN3, in particular its potential impact on behavior, had never been studied. I used morpholino injections to transiently reduce the expression of the zebrafish ortholog lphn3.1. Using behavioral assays, I demonstrated that lphn3.1 morphants display hyperactivity and motor impulsivity at 6 days post fertilization, two characteristics reminiscent of the behavior of ADHD patients. Moreover this abnormal behavior was correlated with a reduced number and misplacement of dopamine (DA) neurons in the ventral diencephalon. Finally, the hyperactivity phenotype could be rescued by the ADHD treatments drugs methylphenidate and atomoxetine (Lange et al., 2012). Because these results suggest that impairments in DA development and neurotransmission may be linked with Lphn3 misfunction and ADHD formation, I next aimed to dissect the DAergic pathways affected by loss of Lphn3 function, using the advantage of zebrafish larvae for pharmacological assays. My analysis of the effects of several non-selective and selective DA agonists and antagonists on the locomotion of lphn3.1 morphant larvae highlights a decreased response to DA drugs in these animals. This is compatible with a model where lphn3.1 morphants would harbor a global increase in DA levels. Indeed, high levels of DA at the synaptic cleft would activate D1-like and D2-like receptors triggering hyperactivity, and would saturates DA transmission, moderating the effects of agonists and antagonists. Although these results are promising, additional work will be required to confirm our hypothesis. In parallel, I also established robust assays to study zebrafish locomotion and novel software to directly sort behavior data. Together, these advances open the way to high-throughput behavioral screens of zebrafish locomotion at different stages. I took advantage of this method to quantify the locomotor ontogeny of six zebrafish strains throughout life (at 6 days, 1 month and 3 months). Overall, zebrafish displayed striking variations in all the behavioral parameters measured, both between strains and over time, highlighting that both environmental and genetic factors alter behavioral reproducibility. Together, the results of this thesis implicate LPHN3 in the etiology of ADHD and in establishing DA signaling during development. They also push forward the advantages of zebrafish for behavioral genetics studies
Role of histamine H1-receptor on behavioral states and wake maintenance during deficiency of a brain activating system: A study using a knockout mouse model( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: Using knockout (KO) mice lacking the histamine (HA)-synthesizing enzyme (histidine decarboxylase, HDC), we have previously shown the importance of histaminergic neurons in maintaining wakefulness (W) under behavioral challenges. Since the central actions of HA are mediated by several receptor subtypes, it remains to be determined which one(s) could be responsible for such a role. We have therefore compared the cortical-EEG, sleep and W under baseline conditions or behavioral/pharmacological stimuli in littermate wild-type (WT) and H1-receptor KO (H1−/−) mice. We found that H1−/− mice shared several characteristics with HDC KO mice, i.e. 1) a decrease in W after lights-off despite its normal baseline daily amount; 2) a decreased EEG slow wave sleep (SWS)/W power ratio; 3) inability to maintain W in response to behavioral challenges demonstrated by a decreased sleep latency when facing various stimuli. These effects were mediated by central H1-receptors. Indeed, in WT mice, injection of triprolidine, a brain-penetrating H1-receptor antagonist increased SWS, whereas ciproxifan (H3-receptor antagonist/inverse agonist) elicited W; all these injections had no effect in H1−/− mice. Finally, H1−/− mice showed markedly greater changes in EEG power (notably in the 0.8–5Hz band) and sleep-wake cycle than in WT mice after application of a cholinergic antagonist or an indirect agonist, i.e., scopolamine or physostigmine. Hence, the role of HA in wake-promotion is largely ensured by H1-receptors. An upregulated cholinergic system may account for a quasi-normal daily amount of W in HDC or H1-receptor KO mice and likely constitutes a major compensatory mechanism when the brain is facing deficiency of an activating system. This article is part of the Special Issue entitled 'Histamine Receptors'. Highlights: Long-term brain histamine deletion impairs EEG & sleep-wake quality causing sleepiness. Such roles are largely mediated by the H1-receptor. The cholinergic system is upregulated to ensure a wake amount in histamine-deficient mice. This constitutes a major compensation when the brain is faced with deficient situations. Understand how the brain remains awake in deficient situation is of physiological/clinical relevance
Brain histamine in the regulation of mammalian hibernation by Tina Sallmén Lozada( Book )

1 edition published in 2002 in English and held by 0 WorldCat member libraries worldwide

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Alternative Names
Panula, P.

Panula, P. 1952-

Panula, P. (Pertti), 1952-

Pertti Panula Finnish professor of biomedicine (University of Helsinki)

Pertti Panula suomalainen biolääketieteen professori Helsingin yliopistossa