WorldCat Identities

González-Lima, Francisco 1955-

Works: 11 works in 32 publications in 2 languages and 302 library holdings
Genres: Conference papers and proceedings  Biography 
Roles: Author, Editor
Publication Timeline
Most widely held works by Francisco González-Lima
Advances in metabolic mapping techniques for brain imaging of behavioral and learning functions : proceedings of the NATO Advanced Research Workshop on Advances in Metabolic Mapping Techniques for Brain Imaging of Behavioral and Learning Functions, Austin Texas, USA, November 7-9 1991 by Francisco González-Lima( )

14 editions published between 1992 and 2013 in English and held by 145 WorldCat member libraries worldwide

In recent years, revolutionary technical advances have permitted neuroscientists to map the functioning of the brain in exquisite detail. Of interest are the new techniques that visually display cell energy metabolism which is coupled to functional brain activity in behaving animals. This is the first book dealing with the application of 2-deoxyglucose and related metabolic mapping techniques for brain imaging of behavioral and learning functions. Quantitative autoradiographic techniques based on the use of exogenous markers include radiolabeled glucose and its analogs, especially 2-deoxyglucose and fluorodeoxyglucose. Other mapping techniques are based on the histochemical staining of endogenous metabolic markers such as cytochrome oxidase, as well as immunohistochemistry for expression of c-fos genes. In spite of the great potential capabilities of the new imaging techniques, relatively few neuroscientists are using this approach to study brain functions related to behavior. There is a need to review state-of-the-art applications of these methods in behavioral neuroscience, and to formulate recommendations for future research in this area. This book is intended to fulfill these needs by bringing together leading neuroscientists using metabolic mapping approaches to elucidate brain mechanisms of behavior. Discussions are not limited to one animal species, but they cover a broad range of vertebrates with unique behavioral capabilities
Cytochrome oxidase in neuronal metabolism and Alzheimer's disease by Francisco González-Lima( Book )

6 editions published in 1998 in English and held by 108 WorldCat member libraries worldwide

Santiago Ramón y Cajal : vida y consejos de un genio de la ciencia by Francisco González-Lima( Book )

4 editions published in 1986 in Spanish and held by 34 WorldCat member libraries worldwide

Neurodegeneration caused by mitochondrial complex I dysfunction in the mouse retina by Xian Zhang( )

1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide

The functional neuroanatomy of helplessness vulnerability by Jason Dee Shumake( )

1 edition published in 2004 in English and held by 3 WorldCat member libraries worldwide

Brain mechanisms of Pavlovian extinction by Douglas Wayne Barrett( )

1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide

Computational approaches to network analysis in functional imaging( Book )

1 edition published in 1994 in English and held by 2 WorldCat member libraries worldwide

Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Highlights: Daily administration of low-dose methylene blue preserved some nigral dopamine cells after 6-OHDA infusion. The mild neuroprotection by methylene blue did not yield an improvement of forepaw functions and attentional disengagement. However, attentional performance in the five-choice task was significantly improved by the same methylene blue treatment. Abstract: Recently, alternative drug therapies for Parkinson's disease (PD) have been investigated as there are many shortcomings of traditional dopamine-based therapies including difficulties in treating cognitive and attentional dysfunction. A promising therapeutic avenue is to target mitochondrial dysfunction and oxidative stress in PD. One option might be the use of methylene blue (MB), an antioxidant and metabolic enhancer. MB has been shown to improve cognitive function in both intact rodents and rodent disease models. Therefore, we investigated whether MB might treat attentional deficits in a rat model of PD induced by 6-hydroxydopamine (6-OHDA). MB also has neuroprotective capabilities against neurotoxic insult, so we also assessed the ability of MB to provide neuroprotection in our PD model. The results show that MB could preserve some dopamine neurons in the substantia nigra par compacta when 6-OHDA was infused into the medial forebrain bundle. This neuroprotection did not yield a significant behavioral improvement when motor functions were measured. However, MB significantly improved attentional performance in the five-choice task designed to measure selective and sustained attention. In conclusion, MB might be useful in improving some attentional function and preserving dopaminergic cells in this model. Future work should continue to study and optimize the abilities of MB for the treatment of PD
Maternal omega-3 fatty acid intake modulates offspring brain metabolism in limbic regions while decreasing reactivity to novel environmental stress by Corey S Jackson( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Prefrontal-limbic Functional Connectivity during Acquisition and Extinction of Conditioned Fear( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Highlights: A new analysis of brain effects of Pavlovian fear conditioning revealed increased fluorodeoxyglucose uptake in the habenula. Metabolic increases were also found in infralimbic cortex in extinction, and amygdala and periaqueductal gray in acquisition. Functional connectivity models revealed novel interactions between these regions during fear acquisition and extinction. Abstract: This study is a new analysis to obtain novel metabolic data on the functional connectivity of prefrontal-limbic regions in Pavlovian fear acquisition and extinction of tone-footshock conditioning. Mice were analyzed with the fluorodeoxyglucose (FDG) autoradiographic method to metabolically map regional brain activity. New FDG data were sampled from the nuclei of the habenula and other regions implicated in aversive conditioning, such as infralimbic cortex, amygdala and periaqueductal gray regions. The activity patterns among these regions were inter-correlated during acquisition, extinction or pseudorandom training to develop a functional connectivity model. Two subdivisions of the habenular complex showed increased activity after acquisition relative to extinction, with the pseudorandom group intermediate between the other two groups. Significant acquisition activation effects were also found in centromedial amygdala, dorsomedial and ventrolateral periaqueductal gray. FDG uptake increases during extinction were found only in dorsal and ventral infralimbic cortex. The overall pattern of activity correlations between these regions revealed extensive but differential functional connectivity during acquisition and extinction training, with less functional connectivity found after pseudorandom training. Interestingly, habenula nuclei showed a distinct pattern of inter-correlations with amygdala nuclei during extinction. The functional connectivity model revealed changing interactions among infralimbic cortex, amygdala, habenula and periaqueductal gray regions through the stages of Pavlovian fear acquisition and extinction. This study provided new data on the contributions of the habenula to fear conditioning, and revealed previously unreported infralimbic-amygdala-habenula-periaqueductal gray interactions implicated in acquisition and extinction of conditioned fear
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Cytochrome oxidase in neuronal metabolism and Alzheimer's disease
Alternative Names
Francisco González joueur de tennis paraguayen

Francisco González Paraguayan tennis player

Francisco González paraguayischer Tennisspieler

Francisco González tennisser uit Paraguay

Francisco González tennista paraguaiano

González, Francisco 1955-

González-Lima, F. 1955-

González-Lima, F. (Francisco), 1955-

Lima, Francisco González- 1955-

Франсиско Гонсалес

فرانسيسكو غونزاليس (تنس)

فرانسيسكو غونزاليس لاعب كرة مضرب باراغواياني

فرانچسکو گونزالس (تنیس‌باز) بازیکن تنیس اهل پاراگوئه