WorldCat Identities

Boehm, Thomas 1956-

Overview
Works: 23 works in 47 publications in 2 languages and 646 library holdings
Roles: Editor, Author, Other
Classifications: RC265, 616.994
Publication Timeline
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Most widely held works by Thomas Boehm
Thymic development and selection of T lymphocytes by Thomas Boehm( )

15 editions published between 2014 and 2016 in English and held by 400 WorldCat member libraries worldwide

The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity
Oncogenes and human cancer ; Blood groups in cancer ; Copper and inflammation ; Human insulin( Book )

6 editions published in 1985 in English and German and held by 84 WorldCat member libraries worldwide

Oncogenes and Human Cancer Blood Groups in Cancer Copper and Inflammation Human Insulin by Thomas Boehm( )

1 edition published in 1985 in English and held by 75 WorldCat member libraries worldwide

L Tumor transformation produces numerous antigenic alterations), particularly 2 among the glycoconjugates, sugars linked to each other, to lipids and to proteins, 3). Many blood group antigens are identified as glycoconjugates; they include the 4 ABO(H), MNT, Lewis, Ii and P antigens). These determinants are particularly valuable since they can be understood in terms of their serology, chemical structure and biochemical genetics4-7). Their specific functions are not well understood; howƯ ever, their position as terminal or penultimate sugars may assign them a special role lO as protective or informational moleculesS- ). Ordinarily, these antigens, equally 4lO described on erythrocytes), persist unchanged throughout the lifetime of the indiƯ vidual, but they may be susceptible to alterations in the presence of certain hematopoietic diseases and solid tissue tumors, primarily carcinomas. A review of 11 this topic was published by one of us in 1980). New data has accumulated rapidly since then, particularly in the areas of structural analysis, biochemical genetics, and immunologic and tumor marker relationships. The purpose of this review is to provide an update of progress realized in these areas. Other reviews with emphasis 12 l5 on special areas are also available - ). Current and prospective experimental studies should be of use in regard to the following questions: 1
Die manipulierte Evolution wie unsere Gesellschaft den genetischen Code verändert by Thomas Boehm( Book )

1 edition published in 2013 in German and held by 16 WorldCat member libraries worldwide

Kann die Lebensweise des Menschen seine Evolution beeinflussen? Die evolutionäre Medizin liefert innovative Einsichten in die Bedeutung von Ernährung, Krankheit und Gesundheitsversorgung für unsere langfristige Entwicklung
Die Beziehung zwischen der enzymatischen Methylierung und der Transkription der DNA im Maus P815 Mastocytom by Thomas Boehm( Book )

4 editions published in 1982 in German and held by 16 WorldCat member libraries worldwide

Francois Devienne's Nouvelle Methode Theorique et Pratique Pour la Flute by Thomas Boehm( )

2 editions published in 2019 in Undetermined and English and held by 14 WorldCat member libraries worldwide

Transgenerational inheritance of impaired larval T cell development in zebrafish by Norimasa Iwanami( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: Evidence for transgenerational inheritance of epigenetic information in vertebrates is scarce. Aberrant patterns of DNA methylation in gametes may set the stage for transmission into future generations. Here, we describe a viable hypomorphic allele of dnmt1 in zebrafish that causes widespread demethylation of CpG dinucleotides in sperm and somatic tissues. We find that homozygous mutants are essentially normal, with the exception of drastically impaired lymphopoiesis, affecting both larval and adult phases of T cell development. The phenotype of impaired larval (but not adult) T cell development is transmitted to subsequent generations by genotypically wildtype fish. We further find that about 200 differentially methylated regions in sperm DNA of transmitting and non-transmitting males, including hypermethylated sites associated with runx3 and rptor genes, whose reduced activities are associated with impaired larval T cell development. Our results indicate a particular sensitivity of larval T cell development to transgenerationally inherited epimutations
Antigen receptor repertoires of one of the smallest known vertebrates by Orlando Bruno Giorgetti( )

1 edition published in 2021 in English and held by 3 WorldCat member libraries worldwide

Abstract: The rules underlying the structure of antigen receptor repertoires are not yet fully defined, despite their enormous importance for the understanding of adaptive immunity. With current technology, the large antigen receptor repertoires of mice and humans cannot be comprehensively studied. To circumvent the problems associated with incomplete sampling, we have studied the immunogenetic features of one of the smallest known vertebrates, the cyprinid fish Paedocypris sp. "Singkep" ("minifish"). Despite its small size, minifish has the key genetic facilities characterizing the principal vertebrate lymphocyte lineages. As described for mammals, the frequency distributions of immunoglobulin and T cell receptor clonotypes exhibit the features of fractal systems, demonstrating that self-similarity is a fundamental property of antigen receptor repertoires of vertebrates, irrespective of body size. Hence, minifish achieve immunocompetence via a few thousand lymphocytes organized in robust scale-free networks, thereby ensuring immune reactivity even when cells are lost or clone sizes fluctuate during immune responses
Co-evolution of mutagenic genome editors and vertebrate adaptive immunity by Inês Trancoso( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Evolution of thymopoietic microenvironments by Ryo Morimoto( )

1 edition published in 2021 in English and held by 3 WorldCat member libraries worldwide

Abstract: In vertebrates, the development of lymphocytes from undifferentiated haematopoietic precursors takes place in so-called primary lymphoid organs, such as the thymus. Therein, lymphocytes undergo a complex differentiation and selection process that culminates in the generation of a pool of mature T cells that collectively express a self-tolerant repertoire of somatically diversified antigen receptors. Throughout this entire process, the microenvironment of the thymus in large parts dictates the sequence and outcome of the lymphopoietic activity. In vertebrates, direct genetic evidence in some species and circumstantial evidence in others suggest that the formation of a functional thymic microenvironment is controlled by members of the Foxn1/4 family of transcription factors. In teleost fishes, both Foxn1 and Foxn4 contribute to thymopoietic activity, whereas Foxn1 is both necessary and sufficient in the mammalian thymus. The evolutionary history of Foxn1/4 genes suggests that an ancient Foxn4 gene lineage gave rise to the Foxn1 genes in early vertebrates, raising the question of the thymopoietic capacity of the ancestor common to all vertebrates. Recent attempts to reconstruct the early events in the evolution of thymopoietic tissues by replacement of the mouse Foxn1 gene by Foxn1-like genes isolated from various chordate species suggest a plausible scenario. It appears that the primordial thymus was a bi-potent lymphoid organ, supporting both B cell and T cell development; however, during the course of vertebrate, evolution B cell development was gradually diminished converting the thymus into a site specialized in T cell development
Long-term robustness of a T-cell system emerging from somatic rescue of a genetic block in T-cell development by Patrick Kury( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: Backgound:<br>The potential of a single progenitor cell to establish and maintain long-term protective T-cellimmunity in humans is unknown. For genetic disorders disabling T-cell immunity, somatic reversion wasshown to support limited T-cell development attenuating the clinical phenotype. However, the casesreported so far deteriorated over time leaving unanswered the important question of long-term activity ofrevertant precursors and the robustness of the resulting T-cell system.<br><br>Methods:<br>We applied TCRb-CDR3 sequencing and mass cytometry on serial samples of a now 18 year-oldSCIDX1 patient with somatic reversion to analyse the longitudinal diversification and stability of a T-cellsystem emerging from somatic gene rescue.<br><br>Findings:<br>We detected close to 105individual CDR3bsequences in the patient. Blood samples of equal sizecontained about 10-fold fewer unique CDR3bsequences compared to healthy donors, indicating a surpris-ingly broad repertoire. Despite dramatic expansions and contractions of individual clonotypes representingup to 30% of the repertoire, stable diversity indices revealed that these transient clonal distortions did notcause long-term repertoire imbalance. Phenotypically, the T-cell system did not show evidence for progres-sive exhaustion. Combined with immunoglobulin substitution, the limited T-cell system in this patientsupported an unremarkable clinical course over 18 years.<br><br>Interpretation:<br>Genetic correction in the appropriate cell type, in our patient most likely in a T-cell biased self-renewing hematopoietic progenitor, can yield a diverse T-cell system that provides long-term repertoirestability, does not show evidence for progressive exhaustion and is capable of providing protective and regu-lated T-cell immunity for at least two decade
Male validation factor for three-spined stickleback (Gasterosteus aculeatus) mate choice likely evolutionarily conserved since 50 thousand years by Christoph L Gahr( )

1 edition published in 2021 in English and held by 3 WorldCat member libraries worldwide

Abstract: During mate choice, three-spined stickleback (Gasterosteus aculeatus) females make use of male olfactory cues to determine the suitability of potential mates in a species- and habitat-dependent manner. This signal contains peptides reflecting the individual male's MHC profile and a so-called male validation factor (MVF) indicating the species identity of the sender. In a two-armed flow channel, we exposed gravid females to male odour. The odours from males that produced only the MVF but no MHC signal yet were used to examine whether the MVF of distant stickleback populations, one from Canada and one from Germany - genetically isolated since approximately 31-59 thousand years - has changed to such a degree that present-day females only react to the MVF produced by males from their population of origin. The fish used in the experiments were bred from in vitro-fertilized eggs in either country; those from Canada were shipped for analysis to the Plön laboratory to minimize experimental variability. Given the choice between the two MVFs, females did not significantly prefer the MVF of males of their own origin over the other. However, compared to water, both types of females preferred their own MVF significantly and the foreign MVF almost significantly, respectively, suggesting that they could smell MVFs from both origins. These results suggest that, despite long-term genetic isolation between Canadian and German populations, the three-spined stickleback male validation factor has remained constant and thus represents an evolutionarily conserved signal
Pervasive changes of mRNA splicing in upf1-deficient zebrafish identify rpl10a as a regulator of T cell development by Divine Fondzenyuy Lawir( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: The transcriptome of eukaryotic cells is constantly monitored for errors to avoid the production of undesired protein variants. The evolutionarily conserved nonsense-mediated mRNA decay (NMD) pathway degrades aberrant mRNAs, but also functions in the regulation of transcript abundance in response to changed physiological states. Here, we describe a zebrafish mutant of upf1, encoding the central component of the NMD machinery. Fish homozygous for the upf1t20450 allele (Y163X) survive until day 10 after fertilization, presenting with impaired T cell development as one of the most conspicuous features of the mutant phenotype. Analysis of differentially expressed genes identified dysregulation of the pre-mRNA splicing pathway, accompanied by perturbed autoregulation of canonical splicing activators (SRSF) and repressors (HNRNP). In upf1-deficient mutants, NMD-susceptible transcripts of ribosomal proteins that are known for their role as noncanonical splicing regulators were greatly increased, most notably, rpl10a. When the levels of NMD-susceptible rpl10a transcripts were artificially increased in zebrafish larvae, T cell development was significantly impaired, suggesting that perturbed autoregulation of rpl10a splicing contributes to failing T cell development in upf1 deficiency. Our results identify an extraribosomal tissue-specific function to rpl10a in the immune system, and thus exemplify the advantages of the zebrafish model to study the effects of upf1-deficiency in the context of a vertebrate organism
Epigenetic protection of vertebrate lymphoid progenitor cells by Dnmt1 by Norimasa Iwanami( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: DNA methylation is a universal epigenetic mechanism involved in regulation of gene expression and genome stability. The DNA maintenance methylase DNMT1 ensures that DNA methylation patterns are faithfully transmitted to daughter cells during cell division. Because loss of DNMT1 is lethal, a pan-organismic analysis of DNMT1 function is lacking. We identified new recessive dnmt1 alleles in medaka and zebrafish and, guided by the structures of mutant proteins, generated a recessive variant of mouse Dnmt1. Each of the three missense mutations studied here distorts the catalytic pocket and reduces enzymatic activity. Because all three DNMT1 mutant animals are viable, it was possible to examine their phenotypes throughout life. The consequences of genome-wide hypomethylation of DNA of somatic tissues in the Dnmt1 mutants are surprisingly mild but consistently affect the development of the lymphoid lineage. Our findings indicate that developing lymphocytes in vertebrates are sensitive to perturbations of DNA maintenance methylation
Lymphocyte-specific function of the DNA polymerase epsilon subunit Pole3 revealed bynNeomorphic alleles by Iliana Siamishi( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: Immunodeficiencies are typically caused by loss-of-function mutations in lymphocyte-specific genes. Occasionally, mutations in ubiquitous general-purpose factors, including those affecting essential components of the DNA polymerase epsilon (POLE) holoenzyme, have cell-type-specific consequences. POLE3, one of the four components of the POLE holoenzyme, features a histone fold domain and a unique acidic C terminus, making it a particularly attractive candidate mediating cell type-specific activities of POLE. Mice lacking Pole3 survive up to late embryonic stages, indicating that this subunit is dispensable for DNA replication. The phenotypes of viable hypomorphic and neomorphic alleles are surprisingly tissue restricted and reveal a stage-specific function of the histone fold domain of Pole3 during T and B cell development. Gradual introduction of positively charged residues into the acidic C terminus leads to peripheral lymphopenia of increasing severity. Our findings serve as a paradigm to understand the molecular basis of cell-type-specific non-replicative functions of the ubiquitous POLE complex
Evolutionary transition from degenerate to nonredundant cytokine signaling networks supporting intrathymic T cell development by Divine Fondzenyuy Lawir( )

1 edition published in 2019 in English and held by 3 WorldCat member libraries worldwide

Typisierung menschlicher Leukämien durch Analyse des DNA-Arrangements von Immunglobulingenen, T-Zellrezeptorgenen und zellulären Onkogenen by Thomas Boehm( Book )

2 editions published in 1988 in German and held by 2 WorldCat member libraries worldwide

Pregnancy-associated diamine oxidase originates from extravillous trophoblasts and is decreased in early-onset preeclampsia by Philipp Velicky( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Fundamental parameters of the developing thymic epithelium in the mouse by Mayumi Hirakawa( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

 
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Thymic development and selection of T lymphocytes
Covers
Oncogenes and human cancer ; Blood groups in cancer ; Copper and inflammation ; Human insulinOncogenes and Human Cancer Blood Groups in Cancer Copper and Inflammation Human InsulinFrancois Devienne's Nouvelle Methode Theorique et Pratique Pour la Flute
Alternative Names
Boehm, T. L. J.

Boehm, T. L. J. (Thomas L. J.), 1956-

Boehm, Thomas L. J.

Boehm, Thomas L.J., 1956-

Böhm, Thomas 1956-

Böhm, Thomas Leo Josef 1956-

Thomas Boehm deutscher Immunologe

Thomas Boehm Duits arts

Thomas Boehm Enseignant de sexe masculin d'Allemagne

Thomas Boehm German physician

Thomas Boehm médecin allemand

Thomas Boehm médico alemán

Thomas Boehm medico tedesco

Thomas Boehm metge alemany

Thomas Boehm mjek gjerman

Thomas Boehm professor académico alemão

Thomas Boehm tysk professor

Languages
English (34)

German (9)