WorldCat Identities

前田, 俊彦 1909-1993

Overview
Works: 20 works in 32 publications in 2 languages and 43 library holdings
Genres: History 
Roles: Author
Classifications: DS485.N7, 915.4
Publication Timeline
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Most widely held works by 俊彦 前田
Sanrizuka : haikō e no ronri( Book )

4 editions published between 1977 and 1982 in Japanese and held by 7 WorldCat member libraries worldwide

Hyōmantei tsūshin by Toshihiko Maeda( Book )

3 editions published in 1969 in Japanese and held by 4 WorldCat member libraries worldwide

Hyakushō wa kome o tsukurazu ta o tsukuru by Toshihiko Maeda( Book )

2 editions published in 2003 in Japanese and held by 4 WorldCat member libraries worldwide

Akirame kara kibō e : takagi jinzaburō taironshū by Jinzaburō Takagi( Book )

2 editions published in 2011 in Japanese and held by 4 WorldCat member libraries worldwide

Konkyochi no shisō kara sato no shisō e by Toshihiko Maeda( Book )

2 editions published in 1971 in Japanese and held by 3 WorldCat member libraries worldwide

Sanrizuka : haikō e no ronri( Book )

2 editions published between 1977 and 1978 in Japanese and held by 3 WorldCat member libraries worldwide

Mori to sato no shisō by Toshihiko Maeda( Book )

2 editions published in 1986 in Japanese and held by 2 WorldCat member libraries worldwide

Sur la frontière indo-afghane ... by A Foucher( Book )

1 edition published in 1988 in Japanese and held by 2 WorldCat member libraries worldwide

Doburoku o tsukurō( Book )

2 editions published in 1981 in Japanese and held by 2 WorldCat member libraries worldwide

Konkyochi no shisō kara sato no shisō e Hyōmantei no tengoku rekihō by Toshihiko Maeda( Book )

2 editions published in 1971 in Japanese and held by 2 WorldCat member libraries worldwide

Hyomantei tsushin( Book )

1 edition published in 1975 in Japanese and held by 1 WorldCat member library worldwide

[Zoku Hyomantei tsushin] by Toshihiko Maeda( Book )

1 edition published in 1975 in Japanese and held by 1 WorldCat member library worldwide

Eejanaika doburoku( Book )

1 edition published in 1986 in Japanese and held by 1 WorldCat member library worldwide

Active form of vitamin D directly protects the blood–brain barrier in multiple sclerosis( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Hyômantei tsûshin : zoku by Toshihiko Maeda( Book )

1 edition published in 1975 in Japanese and held by 1 WorldCat member library worldwide

Fingolimod promotes blood–nerve barrier properties in vitro( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Objective: The main effect of fingolimod is thought to be functional antagonism of lymphocytic S1P1 receptors and the prevention of lymphocyte egress from lymphoid tissues, thereby reducing lymphocyte infiltration into the nervous system. However, a growing number of reports suggest that fingolimod also has a direct effect on several cell types in the nervous system. Although we previously reported that fingolimod enhances blood–brain barrier (BBB) functions, there have been no investigations regarding the blood–nerve barrier (BNB). In this study, we examine how fingolimod affects the BNB. Methods: An immortalized human peripheral nerve microvascular endothelial cell line (HPnMEC) was used to evaluate BNB barrier properties. We examined tight junction proteins and barrier functions of HPnMECs in conditioned medium with or without fingolimod‐phosphate and blood sera from patients with typical chronic inflammatory demyelinating polyneuropathy (CIDP). Results: Incubation with fingolimod‐phosphate increased levels of claudin‐5 mRNA and protein as well as TEER values in HPnMECs. Conversely, typical CIDP sera decreased claudin‐5 mRNA/protein levels and TEER values in HPnMECs; however, pretreatment with fingolimod‐phosphate inhibited the effects of the typical CIDP sera. Conclusions: Fingolimod‐phosphate directly modifies the BNB and enhances barrier properties. This mechanism may be a viable therapeutic target for CIDP, and fingolimod may be useful in patients with typical CIDP who have severe barrier disruption. Abstract : Our study suggests that fingolimod‐phosphate is capable of directly modifying the blood–nerve barrier. Nerve microvascular endothelial cells represent a possible therapeutic target for fingolimod in patients with chronic inflammatory demyelinating polyneuropathy
Stable human brain microvascular endothelial cell line retaining its barrier‐specific nature independent of the passage number( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Abstract Objectives The breakdown of the blood–brain barrier (BBB) has been considered to be a key step in the disease process of a number of neuroimmunological disorders. Although several in vitro BBB models derived from human tissues have been established, no human conditionally immortalized in vitro BBB models using a temperature‐sensitive SV40‐T antigen (tsA58) and human telomerase reverse transcriptase (hTERT) have ever been reported. In the present study, we established a new human brain microvascular endothelial cell line harboring tsA58 and hTERT genes, and extensively characterized this new model. Methods TY08 cells, derived from the human BBB and harboring tsA58, were infected with retroviruses possessing hTERT genes. We examined whether this new model retains its barrier‐specific nature, independent of the passage number. Results The obtained endothelial cell line, termed TY09, proliferated well under the permissive temperature and stopped growing under the non‐permissive temperature, despite the acquisition of hTERT as an additional immortalizing gene. Even with a high‐passage number, the cells maintained a spindle‐shaped morphology, the expression of the von Willebrand factor, tight junction proteins and transporters. Furthermore, we carried out a transendothelial transport study for TY09 cells and hCMEC/D3 cells, thereby proving that both cell lines have almost the same nature with respect to transcellular permeability of various hydrophilic and hydrophobic substances. Conclusions The new stable conditionally immortalized TY09 cells, retaining the in vivo BBB functions, should facilitate the performance of future studies for determining the pathophysiology of various neuroimmunological diseases
Solid State Laser for Preparation of Oxide Superconductor Films by Indika De Silva( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Konkyochi no shisō kara sato no shisō e : Hyōmantei no tenkoku rekihō by Toshihiko Maeda( Book )

1 edition published in 1972 in Japanese and held by 1 WorldCat member library worldwide

Establishment and characterization of spinal cord microvascular endothelial cell lines( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Abstract Objectives The blood–spinal cord barrier (BSCB) has been recognized as one of the barrier organs in the central nervous system. Unlike the blood–brain barrier (BBB), the function of the BSCB still remains to be fully understood, partly because of the lack of a good in vitro BSCB model. In the present study, we established a microvascular endothelial cell line derived from a rat spinal cord and characterized this new model. Methods A conditionally immortalized cell line, termed rBSCB‐1, was established by introducing the temperature‐sensitive SV40 large T‐antigen gene into primary microvascular endothelial cells isolated from a rat spinal cord. We examined whether this model retains barrier‐specific properties. Results The rBSCB‐1 expressed several basic endothelial cell markers and the large T‐antigen, and showed temperature‐dependent cell growth and barrier function. They also expressed tight junction molecules including claudin‐1, 3, 5, 12, occludin, zonula occludens (ZO)‐1 and barrier‐specific transporters. The rBSCB‐1 showed low paracellular permeability to 4kDa dextran and high transport activity of P‐glycoprotein. In addition, the treatment with astrocytic factors increased the barrier properties of rBSCB‐1, including their expression levels of tight junctional molecules. Conclusion The rBSCB‐1 cells are the first conditionally immortalized endothelial cell line derived from the BSCB that have been fully characterized as barrier‐forming cells. This cell line should be a useful tool to understand the BSCB disruption involved in many neurological disorders including multiple sclerosis and spinal cord injury
 
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Audience level: 0.88 (from 0.79 for Hyōmantei ... to 0.97 for Hyomantei ...)

Alternative Names
Maeda, Toshihiko 1909-1993

Toshihiko Maeda homme politique japonais

Toshihiko Maeda Japanese politician

Маэда, Тосихико

マエダ, トシヒコ

マエダ, トシヒコ 1909-1993

前田, 俊彦

前田俊彦

前田俊彦 1909-

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