WorldCat Identities

Jerne, Niels Kaj

Overview
Works: 57 works in 117 publications in 6 languages and 3,373 library holdings
Genres: Biography  History  Periodicals 
Roles: Author, Editor, Honoree, Other, Contributor
Classifications: QR1, 616.079092
Publication Timeline
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Most widely held works by Niels Kaj Jerne
Science as autobiography : the troubled life of Niels Jerne by Thomas Söderqvist( )

8 editions published in 2003 in English and held by 1,641 WorldCat member libraries worldwide

"This biography probes the unusual mind, the dramatic life, and the outstanding scientific work of Danish-born immunologist Niels Jerne (1911-1994). Jerne's Nobel Prize-winning achievements in the field of immunology place him in the pantheon of great twentieth-century biomedical theorists, yet his life is perhaps even more interesting than his science. Science as Autobiography tells Jerne's story, weaving together a narrative of his experiences, emotional life, and scientific work, and arguing that the source of Jerne's extraordinary creativity as a scientist rested in his life story." "Drawing on Jerne's own extensive archives, on more than 150 hours of conversation with him, and on the recollections of over 90 friends, colleagues, and relatives, Thomas Soderqvist explores the myths and legends about Jerne - his unparalleled powers of concentration and analytical keenness, his preference for conversation in a Paris cafe over work in the laboratory, his problematic personal life, Soderqvist punctuates the book with Jerne's own voice and makes the argument that Jerne's life experience and view of himself became a metaphorical resource for the construction of his theories. The author also probes the moral issues that surrounded Jerne's choice to sacrifice the welfare of his family in favor of scientific goals and the pursuit of excellence."--BOOK JACKET
The Immune system( Book )

12 editions published in 1981 in English and Multiple languages and held by 130 WorldCat member libraries worldwide

Current topics in microbiology and immunology = Ergebnisse der Mikrobiologie und Immunitätsforschung by W Arber( )

2 editions published in 1969 in English and held by 74 WorldCat member libraries worldwide

This volume is dedicated to the memory of the late Professor WERNER BRAUN, one of the most devoted and active members of the Editorial Board of the Current Topics in Microbiology and Immunology, who passed away, after suffering a heart attack, in November 1972. Dr. WERNER BRAUN was born in Berlin, Germany, on November 16,1914. During his highschool days in Berlin he did research work on problems of genetics as a young guest in the Kaiser-Wilhelm-Institut fur Biologie, in the department of Prof. R. GOLDSCHMIDT. I remember his colourful description of his discussions during this period, while still a teen-ager, with OTTO WAR­ BURG. He studied biology and medicine at the University of G6ttingen and received a Ph.D. degree in biology in 1936. In the same year he left Nazi Germany and came to the United States first as a Guest Investigator in Genetics at the University of Michigan at Ann Arbor, and then in Berkeley, where he carried out his work in the Depart­ ments of Zoology and of Veterinary Science until 1948. He was engaged during this period in the study of problems concerned with physiological genetics, bacterial variation, immunology and biochemistry
A study of avidity based on rabbit skin responses to diphtheria toxin-antitoxin mixtures by Niels Kaj Jerne( Book )

7 editions published in 1951 in English and German and held by 68 WorldCat member libraries worldwide

The Immune system : festschrift in honor of Niels Kaj Jerne on the occasion of his 70th birthday( Book )

16 editions published in 1981 in English and Multiple languages and held by 59 WorldCat member libraries worldwide

Idiotypic networks( Book )

1 edition published in 1984 in English and held by 54 WorldCat member libraries worldwide

Current topics in microbiology and immunology by W Arber( )

2 editions published in 1975 in English and held by 54 WorldCat member libraries worldwide

The processes involved in herpesvirus replication, latency, and oncogenic transformation, have, in general, been rather poorly defined. A primary reason for this is the size and complexity of the herpesvirus genome. Undoubtedly, a better understanding of the functions of the viral genome in infected and transformed cells will be achieved through studies with temperature-sensitive (ts) mutants of herpesviruses since, theoretically, any essential gene function can be affected by mutants of this type. A. The Herpesviruses A consideration of the genetic analysis of members of the herpesvirus group necessitates a description, albeit brief, of the properties of the group and, most importantly, of their genetic material. The herpesviruses comprise a group of relatively large (100-150 nm), enveloped viruses. The envelope surrounds an icosahedral capsid enclosing a core which contains double­ stranded DNA (ROIZMAN, 1969). The group is thus defined on the basis of a common virion morphology. In addition to a common structure, members of the group share a number of biological properties such as a similar replicative cycle, the ability to cause latent and chronic infections, and the ability to induce antigenic modifications of infected cell membranes. Several herpes­ viruses have been associated recently with malignancies in man and animals (KLEIN, 1972). Herpesviruses are ubiquitous and have been described in over 30 different species (HUNT and MELENDEZ, 1969; WILDY, 1971; FARLEY et aI. , 1972; KAZAMA and SCHORNSTEIN, 1972; NAHMIAS et aI. , 1972; ROlZMAN et aI. , 1973). Their widespread occurrence in nature suggests a common ancestor
Current Topics in Microbiology and Immunology by W Arber( )

1 edition published in 1969 in English and held by 48 WorldCat member libraries worldwide

Current topics in microbiology and immunology : by Werner Arber( )

1 edition published in 1972 in English and held by 46 WorldCat member libraries worldwide

Phenomena as diverse as tuberculin sensitivity, delayed sensitivity to soluble proteins other than tuberculin, contact allergy, homograft rejection, experimental autoallergies, and the response to many microorganisms, have been classified as members of the class of immune reactions known as delayed or cellular hypersensitivity. Similarities in time course, histology, and absence of detectable circulating immunoglobulins characterize these cell-mediated immune reactions in vivo. The state of delayed or cellular hypersensitivity can be transferred from one animal to another by means of sensitized living lymphoid cells (CHASE, 1945; LANDSTEINER and CHASE, 1942; MITCHISON, 1954). The responsible cell has been described by GOWANS (1965) as a small lymphocyte. Passive transfer has also been achieved in the human with extracts of sensitized cells (LAWRENCE, 1959). The in vivo characteristic of delayed hypersensitivity from which the class derives its name is the delayed skin reaction. When an antigen is injected intradermally into a previously immunized animal, the typical delayed reaction begins to appear after 4 hours, reaches a peak at 24 hours, and fades after 48 hours. It is grossly characterized by induration, erythyma, and occasionally necrosis. The histology of the delayed reaction has been studied by numerous investigators (COHEN et al., 1967; GELL and HINDE, 1951; KOSUNEN, 1966; KOSUNEN et al., 1963; MCCLUSKEY et al., 1963; WAKSMAN, 1960; WAKSMAN, 1962). Initially dilatation of the capillaries with exudation of fluid and cells occurs
Current Topics in Microbiology and Immunology : Ergebnisse der Mikrobiologie und Immunitätsforschung by W Arber( )

2 editions published in 1968 in English and held by 46 WorldCat member libraries worldwide

Ever since arbovirus infections became known and their relative importance assessed, experiments were designed to elucidate the mode of transmission and the most important natural hosts responsible for perpetuating the infection in nature. Human infections and the disease in wild rodents, birds, and domestic animals were studied in relation to viremia and distribution of the infectious agent in the organism. With increasing epidemiological studies it became apparent that the neural manifestations of the disease are very uncommon, confined only to a small percentage of individuals of the most susceptible species. Various factors have been proposed to explain why in certain instances the virus becomes establish­ ed in the central nervous system and causes a serious or lethal disease. For example, differences in the virulence of the virus strains, varying susceptibility of individuals of one species, or intercurrent circumstances facilitating access of the virus to the central nervous system were alleged. Also, various possible routes of entry of the virus into the brain and spinal cord have been considered
Current Topics in Microbiology and Immunology / Ergebnisse der Mikrobiologie und Immunitätsforschung by W Arber( )

1 edition published in 1973 in English and held by 45 WorldCat member libraries worldwide

General aspects of nucleic acid uptake by mammalian cells have been the subject of several reviews during the last few years (PAGANO, 1970; BHARGAVA and SHANMUGAM, 1971; DUBES, 1971; RYSER, 1967). These reviews covered methods used for the infection of cells by viral nucleic acids as well as interaction of mammalian cells with non-viral nucleic acids. This article is restricted to a discussion of experiments with poliovirus RNA and focuses special attention on the steps following the uptake of RNA into a cell, aspects that were not discussed in earlier review articles. The fate of input RNA once inside the cell is determined by the host cell but experimental conditions can be chosen to favor the survival of input RNA and the induction of a virus growth cycle by interfering with host-cell meta­ bolism through events that, in the case of infection with intact virus, might be controlled by viral proteins
Current Topics in Microbiology and Immunology : Ergebnisse der Mikrobiologie und Immunitätsforschung by W Arber( )

1 edition published in 1970 in English and held by 43 WorldCat member libraries worldwide

Current topics in microbiology and immunology by W Arber( )

3 editions published in 1974 in English and held by 41 WorldCat member libraries worldwide

Current Topics in Microbiology and Immunology by W Arber( )

2 editions published in 1974 in English and held by 40 WorldCat member libraries worldwide

Prominent progress in molecular biology was only made when it became possible to separate functionally distinct molecules by taking advantage of their biophysical properties. Likewise, the analysis of the functions of hetero­ geneous populations of immunocompetent cells, as to the functional properties of their various subpopulations, can not be done until these can be isolated in reasonably pure form by selective fractionation. During the last few years significant advances have been made in this field, and cells have been separated according to size, density or charge (MILLER et aI. , 1969; SHORTMAN, 1968; ANDERSSON, 1973 c), or by taking advantage of more specific surface markers to allow selective depletion or enrichment of a given subpopulation of cells (WIGZELL and ANDERSSON, 1971). Although separation techniques have been used in a variety of cellular systems, they have been particularly useful in the study of reticuloendothelial cells and primarily in the study of cells partici­ pating in the immune responses. Quite extensive reviews have been written which well cover the methods used for separation of cells and the results obtained with the various approaches (WIGZELL and ANDERSSON, 1971; SHORTMAN, 1972). To review this work is becoming a more and more voluminous task. As data rapidly accumulate, we will not try to make such a complete review
Current Topics in Microbiology and Immunology by W Arber( )

1 edition published in 1974 in English and held by 39 WorldCat member libraries worldwide

Current Topics in Microbiology and Immunology : Ergebnisse der Mikrobiologie und Immunitätsforschung by W Arber( )

1 edition published in 1973 in English and held by 39 WorldCat member libraries worldwide

Current Topics in Microbiology and Immunology by W Arber( )

2 editions published in 1976 in English and held by 39 WorldCat member libraries worldwide

Current topics in microbiology and immunology by W Arber( )

1 edition published in 1972 in English and held by 38 WorldCat member libraries worldwide

25 years, Basel Institute for Immunology : annual report introductions by Niels Kaj Jerne( Book )

4 editions published in 1996 in English and held by 25 WorldCat member libraries worldwide

A portrait of the immune system : scientific publications of N.K. Jerne by Niels Kaj Jerne( )

7 editions published in 1996 in English and held by 14 WorldCat member libraries worldwide

Ivan Lefkovits was born in 1937 and educated in Prague where he worked at the Academy of Sciences. He has lived in Italy, where he worked at the International Laboratory of Genetics and Biophysics, Naples. In 1967 he joined Niels Jerne at the Paul Ehrlich Institute in Frankfurt. In 1969 he became a founding member of the Basel Institute for Immunology, which was created by the pharmaceutical company Hoffmann-La Roche Ltd., Basel, who had the good sense to appoint Niels Jerne as the first director of the Institute; Ivan Lefkovits was a close friend and colleague of Niels Jerne throughout the years in Frankfurt and Basel, and also after Niels Jerne's retirement in south of France. Using the published work of Nobel Laureate Niels Kaj Jerne, this book shows how he developed his ideas. The book is a compilation of his published work, but in fact it is much more than that. Whether the reader wants to read the book systematically, or only browse, it opens a fascinating world of hypotheses, theories, facts and vistas. His selection theory, his view of how immunological diversity is created, and his concept of lymphocytes interacting as a network, reveals Jerne's revolutionary spirit. The book ought to be a rich source of inspiration for everyone interested in science and how science is made
 
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WorldCat IdentitiesRelated Identities
Science as autobiography : the troubled life of Niels Jerne
Covers
A portrait of the immune system : scientific publications of N.K. JerneScience as autobiography : the troubled life of Niels Jerne
Alternative Names
Jerne, N. K.

Jerne, N. K. (Niels Kaj)

Jerne, Niels K. 1911-1994

Jerne, Niels Kaj

Niels Jerne

Niels K. Jerne immunolog brytyjski pochodzenia duńskiego, noblista

Niels Kai Jerne

Niels Kaj Jerne dänischer Immunologe und Nobelpreisträger

Niels Kaj Jerne Danish immunologist

Niels Kaj Jerne dokter asal Denmark

Niels Kaj Jerne immunoloog uit Denemarken (1911-1994)

Niels Kaj Jerne medico danese

Yerne Nils Kay

Ерне, Нильс

Нильс Ерне

Нільс Кай Ернэ

Нільс Єрне

נילס ק. ג'רן

نيلس يرني

نیل کاج جرنی

نیل کای یرنه

نیلز کاج جرنی

닐스 카이 예르네

イェルネ, ニールス カイ

ニールス・イェルネ

尼尔斯·杰尼

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