WorldCat Identities

Pelkonen, R. O. (R. Olavi)

Overview
Works: 31 works in 82 publications in 3 languages and 681 library holdings
Genres: Conference papers and proceedings  Handbooks and manuals 
Roles: Editor, Author, Other
Publication Timeline
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Most widely held works by R. O Pelkonen
Toxicology of herbal products( )

12 editions published between 2016 and 2018 in English and German and held by 220 WorldCat member libraries worldwide

This volume provides a comprehensive overview of the hazards inherent in herbal medicinal products, with systematic coverage of major toxicities. Topics include composition and quality control, toxicokinetics, interactions, safety pharmacology, approaches to studying complex mixtures including metabolomics and systems network pharmacology, and long-term toxicity. The volume also discusses various organ toxicities with a special emphasis on basic mechanisms of actions and the multicomponent and multi-target nature of herbal products. It concludes with a look to future challenges and opportunities. With contributions from noted experts, Toxicology of Herbal Products is a necessary resource for physicians, pharmacists, and toxicologists interested in complex plant-derived products
Enzyme induction in man( Book )

6 editions published in 1987 in English and held by 122 WorldCat member libraries worldwide

Pharmacokinetic challenges in drug discovery( Book )

9 editions published between 2002 and 2014 in English and held by 113 WorldCat member libraries worldwide

Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies
Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobiotics by Costas Ioannides( )

5 editions published in 2008 in English and held by 90 WorldCat member libraries worldwide

With contributions by a team of internationally respected scientists, this book provides up-to-date information on the extensively studied cytochrome P450 enzyme in a very accessible manner, During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level
Interindividual variability in human drug metabolism( Book )

8 editions published between 2001 and 2014 in English and held by 86 WorldCat member libraries worldwide

The book provides an exhaustive, authoritative and updated review on the interindividual variability in drug metabolism in humans. Four chapters address the general background: genetic factors causing variability, interethnic variability, environmental factors and developing and ageing as sources of variability. Six chapters address variability of drug metabolism in vivo: variability of psychotropic drugs, antiepileptic drugs, the dopamine precursor levodopa, cardiovascular active drugs and anti HIV drugs. Seven chapters address the interindividual variability of the main drug metabolizing enzymes: CYP-450s, acetyltransferases, glucuronosyl transferase, methyl transferases, sulfotransferases and glutathione transferases in human liver and extrahepatic tissues. A separate chapter discusses the prediction of drug interaction.Comprehensive in coverage, and with contributions from the leading international experts, this book is essential reading for researchers from both academia and the pharmaceutical industry. Advanced undergraduates and postgraduates in pharmacology, clinical pharmacology, toxicology, biochemistry and epidemiology who are interested in drug metabolism will also find this an indispensable resource
Annual symposium of the Finnish Society of Toxicology = Suomen toksikologiyhdistyksen vuosikokous : Oulu, 8.-9.5.1987 by Suomen toksikologiyhdistys( Book )

3 editions published in 1987 in English and held by 7 WorldCat member libraries worldwide

Studies on drug metabolizing enzymes in the human fetus by R. O Pelkonen( Book )

4 editions published in 1973 in English and held by 6 WorldCat member libraries worldwide

Plasma vitamin A and E in the study of lipid and lipoprotein metabolism in coronary heart disease by R. O Pelkonen( Book )

4 editions published in 1963 in English and held by 6 WorldCat member libraries worldwide

Lääketieteellinen farmakologia ja toksikologia( Book )

6 editions published between 1995 and 2003 in Finnish and held by 4 WorldCat member libraries worldwide

Toksikologisymposium 1986 : tiivistelmät = Symposium on Toxicology, Reproductive Toxicology and Ecotoxicology ; abstracts ; Joensuu 4.-5.4.1986 by Toksikologisymposium( Book )

2 editions published in 1986 in English and held by 2 WorldCat member libraries worldwide

Scientifically unfounded precaution drives European Commission's recommendations on EDC regulation, while defying common sense, well-established science and risk assessment principles by Daniel R Dietrich( )

2 editions published between 2013 and 2014 in English and held by 2 WorldCat member libraries worldwide

Principles of Pharmacology and Toxicology : Also Govern Effects of Chemicals on the Endocrine System by Herman Autrup( )

1 edition published in 2015 in English and held by 2 WorldCat member libraries worldwide

A roadmap for the development of alternative (non-animal) methods for systemic toxicity testing by David A Basketter( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

Lääkkeet raskauden ja imetyksen aikana : "Skylla ja Kharybdis" by Kirsi Vähäkangas( Book )

2 editions published in 2000 in Finnish and held by 2 WorldCat member libraries worldwide

Network Pharmacology and Traditional Chinese Medicine by Qihe Xu( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Scientific Opinion on the state of the science on pesticide risk assessment for amphibians and reptiles( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Following a request from EFSA, the Panelon Plant Protection Products and their Residues developed an opinion on the science to support the potential development of a risk assessment scheme of plant protection products for amphibians and reptiles. The coverage of the risk to amphibians and reptiles by current risk assessments for other vertebrate groups was investigated. Available test methods and exposure models were reviewed with regard to their applicability to amphibians and reptiles. Proposals were made for specific protection goals aiming to protect important ecosystem services and taking into consideration the regulatory framework and existing protection goals for other vertebrates. Uncertainties, knowledge gaps and research needs were highlighted. Abstract : This publication is linked to the following EFSA Supporting Publications article:http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2018.EN-1357/full
Drug metabolism and cytochromes P450 : Olavi Pelkonen, 50 years( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

Pharmacokinetic challenges in drug discovery : with tables( Book )

1 edition published in 2002 in English and held by 1 WorldCat member library worldwide

Tutkijankoulutuksen kehittäminen farmakologian ja lähitieteiden alueella by R. O Pelkonen( Book )

1 edition published in 1991 in Finnish and held by 1 WorldCat member library worldwide

 
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Interindividual variability in human drug metabolism
Covers
Cytochromes P450 : role in the metabolism and toxicity of drugs and other xenobioticsInterindividual variability in human drug metabolismPharmacokinetic challenges in drug discovery : with tables
Alternative Names
Olavi Pelkonen Finnish professor of pharmacology (University of Oulu)

Pelkonen, O.

Pelkonen, O. 1945-

Pelkonen, O. (Olavi)

Pelkonen, Olavi

Languages