WorldCat Identities

Normark, Staffan

Overview
Works: 17 works in 27 publications in 2 languages and 205 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Contributor, Author, Other
Classifications: QR175, 571.629
Publication Timeline
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Most widely held works by Staffan Normark
Cellular microbiology by Pascale Cossart( )

7 editions published between 1999 and 2005 in English and held by 173 WorldCat member libraries worldwide

The term "cellular microbiology" was coined in 1996 to identify an emerging discipline integrating the fields of cell biology and microbiology. The advent of genomics, proteomics, and postgenomics has resulted in more widespread understanding of the field of cellular microbiology among scientists. Cellular Microbiology, 2nd Edition, considers genomic information and advances in technology in an updated examination of this burgeoning area of important research
Genetic, physiological and ultrastructural studies on a chain-forming mutant of Escherichia coli K 12 with increased sensitivity to several antibiotics by Staffan Normark( Book )

3 editions published in 1971 in English and Swedish and held by 8 WorldCat member libraries worldwide

Genetics and immunobiology of pathogenic Neisseria : proceedings of an EMBO Workshop held at Hemavan, Sweden 16-19, June, 1980( Book )

3 editions published between 1980 and 1981 in English and held by 6 WorldCat member libraries worldwide

The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract by Henrik Tomenius( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy by Kristina Jonas( )

1 edition published in 2007 in English and held by 2 WorldCat member libraries worldwide

The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease by Jenny Fernebro( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells by Sandra Muschiol( )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

Metagenomic study of Helicobacter pylori microdissected from archived formalin-fixed paraffin-embedded biopsy sections by Zongli Zheng( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

Genetics and immunobiology of pathogenic neisseria : Workshop : Papers( Book )

1 edition published in 1980 in English and held by 1 WorldCat member library worldwide

Berättelse över Kungl. Vetenskapsakademiens verksamhet( Book )

1 edition published in 2013 in Swedish and held by 1 WorldCat member library worldwide

Berättelse över Kungl. Vetenskapsakademiens verksamhet( Book )

1 edition published in 2014 in Swedish and held by 1 WorldCat member library worldwide

The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism by Elisabeth Reithuber( )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

Streptococcus pneumoniae, a major cause of pneumonia, sepsis, and meningitis worldwide, has the nasopharynges of small children as its main ecological niche. Depletion of pneumococci from this niche would reduce the disease burden and could be achieved using small molecules with narrow-spectrum antibacterial activity. We identified the alkylated dicyclohexyl carboxylic acid 2CCA-1 as a potent inducer of autolysin-mediated lysis of S. pneumoniae, while having low activity against Staphylococcus aureus. 2CCA-1-resistant strains were found to have inactivating mutations in fakB3, known to be required for uptake of host polyunsaturated fatty acids, as well as through inactivation of the transcriptional regulator gene fabT, vital for endogenous, de novo fatty acid synthesis regulation. Structure activity relationship exploration revealed that, besides the central dicyclohexyl group, the fatty acid-like structural features of 2CCA-1 were essential for its activity. The lysis-inducing activity of 2CCA-1 was considerably more potent than that of free fatty acids and required growing bacteria, suggesting that 2CCA-1 needs to be metabolized to exert its antimicrobial activity. Total lipid analysis of 2CCA-1 treated bacteria identified unique masses that were modeled to 2CCA-1 containing lysophosphatidic and phosphatidic acid in wild-type but not in fakB3 mutant bacteria. This suggests that 2CCA-1 is metabolized as a fatty acid via FakB3 and utilized as a phospholipid building block, leading to accumulation of toxic phospholipid species. Analysis of FabT-mediated fakB3 expression elucidates how the pneumococcus could ensure membrane homeostasis and concurrent economic use of host-derived fatty acids.IMPORTANCE Fatty acid biosynthesis is an attractive antibiotic target, as it affects the supply of membrane phospholipid building blocks. In Streptococcus pneumoniae, it is not sufficient to target only the endogenous fatty acid synthesis machinery, as uptake of host fatty acids may bypass this inhibition. Here, we describe a small-molecule compound, 2CCA-1, with potent bactericidal activity that upon interactions with the fatty acid binding protein FakB3, which is present in a limited number of Gram-positive species, becomes metabolized and incorporated as a toxic phospholipid species. Resistance to 2CCA-1 developed specifically in fakB3 and the regulatory gene fabT. These mutants reveal a regulatory connection between the extracellular polyunsaturated fatty acid metabolism and endogenous fatty acid synthesis in S. pneumoniae, which could ensure balance between efficient scavenging of host polyunsaturated fatty acids and membrane homeostasis. The data might be useful in the identification of narrow-spectrum treatment strategies to selectively target members of the Lactobacillales such as S. pneumoniae
Evaluation of new beta-lactam antibiotics : this symposium is dedicated to the memory of Stellan Ericson( Book )

1 edition published in 1986 in English and held by 1 WorldCat member library worldwide

THCz Small molecules with antimicrobial activity that block cell wall lipid intermediates by Elisabeth Reithuber( )

1 edition published in 2021 in English and held by 1 WorldCat member library worldwide

Emerging antibiotic resistance demands identification of novel antibacterial compound classes. A bacterial whole-cell screen based on pneumococcal autolysin-mediated lysis induction was developed to identify potential bacterial cell wall synthesis inhibitors. A hit class comprising a 1-amino substituted tetrahydrocarbazole (THCz) scaffold, containing two essential amine groups, displayed bactericidal activity against a broad range of gram-positive and selected gram-negative pathogens in the low micromolar range. Mode of action studies revealed that THCz inhibit cell envelope synthesis by targeting undecaprenyl pyrophosphate-containing lipid intermediates and thus simultaneously inhibit peptidoglycan, teichoic acid, and polysaccharide capsule biosynthesis. Resistance did not readily develop in vitro, and the ease of synthesizing and modifying these small molecules, as compared to natural lipid II-binding antibiotics, makes THCz promising scaffolds for development of cell wall-targeting antimicrobials
Genetic, physiological and ultrastructural studies on a chain-forming mutant of Escherichia coli K12 with increased sensitivity to several antibiotics by Staffan Normark( Book )

1 edition published in 1971 in English and held by 1 WorldCat member library worldwide

Genetics of digalactoside-binding adhesin from a uropathogenic "Escherichia coli" strain( Book )

1 edition published in 1983 in English and held by 1 WorldCat member library worldwide

Genetics and immunobiology of pathogenic neisseria, proceedings of an EMBO workshop( Book )

1 edition published in 1980 in English and held by 0 WorldCat member libraries worldwide

 
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Cellular microbiology
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Alternative Names
Staffan Normark médicu suecu

Staffan Normark schwedischer Arzt

Staffan Normark Swedish microbiologist and physician

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