WorldCat Identities

Clayton, David 1944-

Works: 4 works in 53 publications in 3 languages and 843 library holdings
Roles: Author
Classifications: RA652.2.M3, 614.4072
Publication Timeline
Most widely held works about David Clayton
Most widely held works by David Clayton
Statistical models in epidemiology by David Clayton( Book )

50 editions published between 1992 and 2013 in 4 languages and held by 471 WorldCat member libraries worldwide

This self-contained account of the statistical basis of epidemiology has been written for those with a basic training in biology. It is specifically intended for students enrolled for a masters degree in epidemiology, clinical epidemiology, or biostatistics
Searching for genetic association using (Haplotype) tagging SNPs by David Clayton( )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

Audio-visual presentation : The htSNP approach - R-square criterion for assessment - Power - Complexity vs. accuracy - Case studies: 4 gene regions - From htSNPs to causal variants - Quantitative traits - 1 df for dominance
The role of atypical PKC in the plasticity of the circadian clock in the rat suprachiasmatic nucleus by Sufang Huang( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

In mammals, the daily rhythms of biological functions are generated by the master circadian clock, which locates within the suprachiasmatic nucleus (SCN) of the hypothalamus. The endogenous circadian rhythms generated by the SCN are actively synchronized by the environmental light. The photic signals are transferred by the excitatory neurotransmitter, glutamate (GLU), via the retinohypothalamic tract from the retina to the SCN. Light/GLU pulses can reset the mammalian circadian clock at specific times: in the early night, light/GLU delays clock phase, whereas in the late night, light/GLU advances it. The changes of clock temporal status by light/GLU are highly regulated by phosphorylation events. In this study, we examined the role of atypical protein kinase C (aPKC) in GLU signaling. We found that the phosphotransferase activity of aPKC is increased significantly by GLU treatment to SCN brain slices at CT 14 in the early night. Disruption of aPKC phosphotransferase activity completely blocks GLU-induced phase delays in the early night, but not phase advances in the late night, demonstrating that aPKC is essential for GLU-induced phase delays only. Furthermore, we found that aPKC is activated by GLU by inducing the protein level of aPKC. Studies on glycogen synthase kinase-3beta (GSK-3beta) and TIMELESS show that these two proteins may be regulated by aPKC in the rat SCN. A model is proposed that describes the current understanding of the glutamate signaling pathway mediated by aPKC in the early night in the rat SCN
Audience Level
Audience Level
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Audience level: 0.45 (from 0.22 for Evade! eva ... to 0.83 for The role o ...)

Statistical models in epidemiology
Alternative Names
Clayton, David George 1944-

Clayton, David statistician

David Clayton British statistician