WorldCat Identities

Krieglstein, Kerstin

Overview
Works: 15 works in 28 publications in 2 languages and 375 library holdings
Roles: Other, Author, dgs, Editor
Publication Timeline
.
Most widely held works by Kerstin Krieglstein
Cell signaling and growth factors in development : from molecules to organogenesis by Klaus Unsicker( Book )

12 editions published between 2006 and 2008 in English and held by 300 WorldCat member libraries worldwide

Combining a comprehensive treatment of both embryogenesis and organ development in one reference work, this handbook is structured according to organ systems. It addresses the functions of all signaling pathways and growth factors important for the development of the embryo and the adult. With its focus on vertebrates, this volume provides an overview of the molecular communication regulating such processes as cell division, migration, and differentiation. Additionally, sections on developmental disorders and related novel therapeutic strategies highlight applications in molecular medicine
Investigation of Sip1 gene interactions in the development of the mammalian telencephalon by Anjana Nityanandam( )

2 editions published between 2009 and 2010 in English and held by 25 WorldCat member libraries worldwide

The transcriptional repressor Sip1, or Smad- interacting protein 1, has been shown to play a key role in early neurodevelopment. Mowat- Wilson Syndrome in humans is associated with mutations in Sip1. In the developing mouse cerebral cortex, it is expressed mostly in the differentiating field, and weakly in the proliferative zones. We found that stage and tissue specific ablation of Sip1 leads to several defects in the development of the neocortex. Deletion of Sip1 in cortical progenitors as well as exclusively in postmitotic cortical plate neurons, led to a reduction in the size of deep layer neuronal populations and precocious generation of cortical layers 2-5. Further studies showed that while the onset of neurogenesis is unaffected, this process ends prematurely in conditional Sip1 mutants. We also observed an increase in astrocyte production, and traced its origin to increased and ectopic proliferation of astrocytic progenitors at E17.5, and premature specification of glial precursors at E16.5. Furthermore, elevated proliferation in the cingulate cortex continued until early postnatal stages in the mutant. Our data suggest a possible non- cell autonomous effect of Sip1 on the specification of deep layer versus upper layer neuronal fate, and neuronal versus astrocytic fate of progenitors in the germinal zone, at early and late stages of development, respectively. Comparison of gene expression profile between wildtype and Sip1 conditional knockouts enabled us to identify the growth factors, Neurotrophin-3 (NT3) and Fgf9 as putative downstream targets of Sip1 in the cortex
Über die Struktur von Tetanustoxin und Botulinum A-Toxin : Lokalisation der Disulfidbrücken, der Sulfhydrylgruppen und limitierte Proteolyse by Kerstin Krieglstein( )

2 editions published in 1990 in German and held by 15 WorldCat member libraries worldwide

Untersuchungen zur Rolle von Klf10 und Klf11 als Mediatoren von NGF- und TGF-[beta]-vermittelten Effekten in Zellen neuraler Herkunft by Gabriele Spittau( )

1 edition published in 2012 in German and held by 13 WorldCat member libraries worldwide

The TGF-ß1/Klf-family of transcription factors. They play important roles in development and maintenance of various tissues and cell types. The publications consolidated in this thesis describe, that Klf11 mimics TGF-ß effects by inducing apoptotsis accompanied by activation of cysteine-dependent aspartate-specific protease 3 (Caspase-3). Further the thesis demonstrates that Klf11 represses the expression of the inhibitory Sma and Mad related protein 7 (Smad7) and disrupts the negative-feedback loop of the TGF-ß signaling pathway. Loss of the N-terminal repression domains of Klf11 abrogates its proapoptotic nature and the repression of Smad7. In conclusion, the evidence was given that the transcription factor Klf11 is a downstream mediator of TGF-ß-induced apoptosis and a potent modulator of the TGF-ß signaling pathway in the oligodendroglial cell line Oli-neu.In a second part of this thesis it has been shown by using semiquantitative PCR and immunoblotting, that nerve growth factor (NGF), a member of the neurotrophin family, regulates the expression of Klf10 in the pheochromocytoma cell line PC12 in a tropomyosin related kinase A- (TrkA) dependent manner. Moreover, the thesis provides evidence for the existence of NGF-responsive elements in the 5-́regulatory region of Klf10, that contain binding sites for the transcription factors specificity protein 1 (Sp1) and cAMP response-element binding protein (CREB)
Growth factors in development : from cell signaling to organ systems( Book )

1 edition published in 2005 in English and held by 4 WorldCat member libraries worldwide

<>( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

<>( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

TGF-ß in aging and disease( Book )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Neurale Funktionen transformierender Wachstumsfaktoren beta (TGF-beta) : neurotrophe Wirkungen am Beispiel zentraler und peripherer Neuronpopulationen by Kerstin Krieglstein( Book )

1 edition published in 1996 in German and held by 1 WorldCat member library worldwide

TGF[beta]-facilitated optic fissure fusion and the role of bone morphogenetic protein antagonism by Max Knickmeyer( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

VHL and Hypoxia regulated genes in sympatho-adrenal cell lineage Development and Disease by Tehani Ali Omer Elfaitwri( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Zusammenfassung: VHL and Hypoxia regulated genes in sympatho- adrenal cell lineage Development and DiseaseAbstractCells of the sympatho-adrenal (SA) cell lineage develop from neural crest cells (NCCs). Abnormal development of SA cells has been linked to various tumors, including neuroblastoma (NB), and Pheochromocytoma (PCC). In humans mutations of the Von Hippel Lindau tumor suppressor gene (VHL), a negative regulator of hypoxia inducible factors, is one of the major causes of PCC development. .Mammalian embryos develop within a hypoxic environment, under the influence of hypoxia inducible factors (HIFs). HIFs have been linked to various diseases, including NB, due to their impact on cellular differentiation. Delta like homolog 1 (DLK-1) is another gene implicated in neuroblastoma, which is hypoxia regulated and lies downstream of HIF system. However, the main role of VHL and hypoxia-inducible factors during normal development of SA cells is unclear up to date.The aim of the current study was to investigate the in vivo role of VHL on the normal development of SA cells and to investigate, whether the loss of VHL function leads to SA derived tumor development as pheochromocytoma
TGF-beta signaling plays an important role in IL4-induced alternative activation of microglia by Xiaolai Zhou( )

1 edition published in 2012 in English and held by 1 WorldCat member library worldwide

Cell Signaling and Growth Factors in Development( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

This is the first handbook structured according to organ systems to cover both embryogenesis and organ development. It addresses the functions of developmental signaling pathways and growth factors with a focus on cell division, cell migration, and cell differentiation. A uniform article structure throughout the book facilitates easy comparison of data. Applications in molecular medicine are highlighted with chapters on developmental disorders and related novel therapeutic strategies
 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.66 (from 0.53 for Growth fac ... to 0.95 for TGF-ß in a ...)

Cell signaling and growth factors in development : from molecules to organogenesis Growth factors in development : from cell signaling to organ systems
Covers
Growth factors in development : from cell signaling to organ systems
Alternative Names
Kerstin Krieglstein-Unsicker deutsche Neurowissenschaftlerin. Sie ist die designierte Rektorin der Universität Konstanz

Krieglstein-Unsicker, Kerstin 1963-

Unsicker, Kerstin Krieglstein- 1963-

Languages
English (24)

German (4)