WorldCat Identities

Harris, Samantha

Overview
Works: 4 works in 4 publications in 1 language and 420 library holdings
Genres: Motion picture music  Academic theses  Musicals 
Roles: Author, Performer
Classifications: RC268, 616.994
Publication Timeline
.
Most widely held works by Samantha Harris
Your healthiest healthy : 8 easy ways to take control, help prevent and fight cancer, and live a longer, cleaner, happier life by Samantha Harris( Book )

1 edition published in 2018 in English and held by 367 WorldCat member libraries worldwide

"Millions watched Samantha Harris share the story of her breast cancer diagnosis and double mastectomy at age 40. Now she offers an easy, eight-step plan for overcoming adversity, helping to fight cancer, and living a healthier, happier life. Your Healthiest Healthy combines her inspiring journey with research-backed advice, recipe and menu guides, workout charts, milestone logs, relationship activities, cheat sheets, checklists, and other must-have tools and resources."--Publisher
Reefer madness : the movie musical ; Reefer madness! : original Los Angeles cast recording by Dan Studney( Recording )

1 edition published in 2008 in English and held by 51 WorldCat member libraries worldwide

An anatomical investigation of the mandibular first molar using micro-computed tomography by Samantha Harris( )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

Orientation of Myosin Binding Protein C in the Cardiac Muscle Sarcomere Determined by Domain-Specific Immuno-EM( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract: Myosin binding protein C is a thick filament protein of vertebrate striated muscle. The cardiac isoform [cardiac myosin binding protein C (cMyBP-C)] is essential for normal cardiac function, and mutations in cMyBP-C cause cardiac muscle disease. The rod-shaped molecule is composed primarily of 11 immunoglobulin- or fibronectin-like domains and is located at nine sites, 43 nm apart, in each half of the A-band. To understand how cMyBP-C functions, it is important to know its structural organization in the sarcomere, as this will affect its ability to interact with other sarcomeric proteins. Several models, in which cMyBP-C wraps around, extends radially from, or runs axially along the thick filament, have been proposed. Our goal was to define cMyBP-C orientation by determining the relative axial positions of different cMyBP-C domains. Immuno-electron microscopy was performed using mouse cardiac myofibrils labeled with antibodies specific to the N- and C-terminal domains and to the middle of cMyBP-C. Antibodies to all regions of the molecule, except the C-terminus, labeled at the same nine axial positions in each half A-band, consistent with a circumferential and/or radial rather than an axial orientation of the bulk of the molecule. The C-terminal antibody stripes were slightly displaced axially, demonstrating an axial orientation of the C-terminal three domains, with the C-terminus closer to the M-line. These results, combined with previous studies, suggest that the C-terminal domains of cMyBP-C run along the thick filament surface, while the N-terminus extends toward neighboring thin filaments. This organization provides a structural framework for understanding cMyBP-C's modulation of cardiac muscle contraction. Graphical abstract: Highlights: The organization of cMyBP-C in the cardiac muscle sarcomere is controversial. Cardiac muscle myofibrils were labeled with domain-specific antibodies to cMyBP-C. The antibodies revealed the axial positions of different domains of cMyBP-C. Different domains were located at the same axial positions along the thick filament. We conclude that most of cMyBP-C is oriented perpendicular to the thick filament
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.20 (from 0.17 for Your healt ... to 0.88 for Orientatio ...)

WorldCat IdentitiesRelated Identities
Alternative Names
Harris, Samantha P.

Samantha Harris actrice américaine

Samantha Harris American model, actress and television personality/presenter

Samantha Harris Amerikaans actrice

Samantha Harris US-amerikanische Schauspielerin, Fernsehmoderatorin und Journalistin

Харрис, Саманта

סמנתה האריס שחקנית אמריקאית

سامانتا هریس مجری تلویزیونی، ژورنالیست، و بازیگر آمریکایی

سامانثا هاريس

Languages