WorldCat Identities

Allen, Andy (Athletic trainer)

Works: 1 works in 1 publications in 1 language and 1 library holdings
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Classifications: LB1028.M3,
Publication Timeline
Most widely held works by Andy Allen
The impact of acute exercise on factor VIII in young e-cigarette smokers by Andy Allen( )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

Abstract Background: There is a strong association between factor VIII (FVIII) and presence of cardiovascular disease (CVD). Exercise is a known trigger for myocardial infarction, and the majority of ischemic events from physical stress occur due to an occlusive thrombus. FVIII increases acutely with exercise and remains elevated hours after exercise. Furthermore, FVIII is also higher in cigarette smokers, however, it has not been investigated in e-cigarette smokers. The purpose of this study is to identify potential differences in FVIII before exercise, after exercise, and its magnitude of change in e-cigarette users versus non-users. Methods: Eighteen individuals (8 e-cigarette users, 3 women and 5 men, and 10 non-smokers, 7 women and 3 men; age, 18-32 years old) were recruited to participate in this research study. An incremental test to exhaustion (x̄=12.20 ± 3.20 minutes) was performed on an electronically braked cycle ergometer (Lode Corival cpet; Groningen, Netherlands) to determine the peak rate of oxygen consumption (VO<sub>2peak</sub>). Ten mL of blood was drawn into a citrate anticoagulant solution from an antecubital vein using clean venipuncture with minimal stasis both prior to and immediately following exercise testing. A commercially available ELISA kit was used to determine plasma concentrations of coagulation FVIII antigen. Results: There was no significant difference between smokers (N = 8, 4.35 ± 2.09 IU/ml) and nonsmokers (N = 9, 5.02 ± 4.87 IU/ml, p=0.72) for resting FVIII antigen. There was a main effect for exercise in that the post-exercise values (N=10, 7.76 ±1.40 IU/ml) were larger than pre-exercise values (N=10, 3.82 ± 0.65, p=0.003). However, there was no main effect for smoking and no smoking x exercise interaction (post-exercise smokers, N=4, 6.67 ± 1.46, post-exercise non-smokers, N= 7, 8.39 ± 5.81, p=0.58). Conclusion: Our preliminary data suggests that e-cig use does not significantly affect FVIII or the FVIII response to exercise
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Alternative Names
Allen, Andrew (Athletic trainer)