WorldCat Identities

Khan, Asad U.

Overview
Works: 9 works in 13 publications in 1 language and 81 library holdings
Roles: Author
Classifications: RM666.B46, 615.329
Publication Timeline
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Most widely held works by Asad U Khan
Multidrug Resistance A Global Concern by Asad Ullah Khan( )

5 editions published in 2012 in English and held by 68 WorldCat member libraries worldwide

Annotation
Current trends in antibiotic resistance in infectious diseases( Book )

1 edition published in 2009 in English and held by 6 WorldCat member libraries worldwide

Designing, synthesis, and antimicrobial action of oxazoline and thiazoline derivatives of fatty acid esters( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : In this study, a novel series of oxazoline and thiazoline were designed as inhibitors of cytochrome P450 14 alpha-sterol demethylase (CYP51) from Candida albicans and peptide deformylase (PDF) of Escherichia coli . The long chain dibromo derivative of fatty acid esters on reaction with urea and thiourea gave their corresponding oxazolines and thiazolines, respectively. All the compounds were characterized by their spectral data (IR, 1 H NMR, 13 C NMR and MS) and tested for antibacterial and antifungal activity by disk diffusion assay and minimum inhibitory concentration by the broth microdilution method against gram-positive and gram-negative strains of bacteria as well as fungus strains. The investigation into antimicrobial screening revealed that all the compounds were found to be potent antimicrobial agents. After calculating likeness drug properties of the compounds by Prediction of Activity Spectra for Substances software, ADMET-related descriptors were computed to predict the pharmacokinetic properties for the active and bioavailable compounds by discovery studio 2.5. Molecular docking studies have been performed on PDF of E. coli and CYP 450-14DM of C. albicans to understand the mode of binding of the molecules in the active site of the receptor. Compounds (2-amino-5-(carbomethoxyoctyl)-1, 3-oxazoline, 2-amino-5-(carbomethoxyoctyl)-1, 3-thiazoline and 2-amino-4-pentyl-5-[(8'R)-8' hydroxy (carbomethoxydecyl)-1, 3-oxazoline) showed excellent antimicrobial activity nearly equivalent to the control compounds and compounds, 2-amino-4-octyl-5-(carbomethoxyheptyl)-1, 3-oxazolin, 2-amino-4-(2'R)(2'-hydroxy octyl)-5-(carbomethoxyheptyl)-1, 3-oxazoline and 2-amino-4-pentyl-5-[(8'R)-8'-hydroxy(carbomethoxy decyl)-1, 3-oxazolineshowed vasodilation and antihypertensive properties. Furthermore, a computational analysis of physicochemical parameters revealed that the most of the compounds possessed drug-like attributes. Using Bioinformatics approach, we found a correlation between the observed and predicted antimicrobial activities. Abstract : A series of novel oxazoline and thiazoline derivatives of long chain unsaturated fatty acid esters were synthesized from urea and thiourea, respectively, and screened for their antibacterial activity against Escherichia coli, Methicillin-resistant Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pyogenes, Klebsiella pneumonia and antifungal activity against Candida albicans, Aspergillus fumigatus, Penicillium marneffei, Trichophyton mentagrophytes
Retracted: Novel spiro-thiazolidin-4-one and thioether derivatives of benzylidene flavanones: New leads in cancer and microbial chemotherapy( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Retraction: The above article from Archiv der Pharmazie, published online on 12 March 2018 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor-in-Chief, Prof. Holger Stark, and Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The retraction has been agreed due to errors in the spectroscopic data of the investigated new compounds. Reference to Retraction: S. Mukhtar, M.A. Alsharif, M.I. Alahmdi, H. Parveen, A.U. Khan, Arch. Pharm. Chem. Life Sci . 2018;1-12. DOI:10.1002/ardp. 201700397
Plasmid-mediated multiple antibiotic resistance in Proteus mirabilis isolated from patients with urinary tract infection by Asad U Khan( )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

Environmental issues regarding CO2 and recent strategies for alternative fuels through photocatalytic reduction with titania-based materials( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Graphical abstract: Highlights: Environmental issues regarding CO2 and recent strategies for alternative fuels. CO2 utilization technologies for renewable fuel formation. Photocatalytic reduction of CO2 with titania-based materials. Abstract: Carbon dioxide (CO2) is considered one of the main contributors to the greenhouse effect and is currently a key challenge throughout the world. Therefore, the CO2 complications associated with the environment have in particular been focused on in this review, and various strategies regarding CO2 mitigation, or the utilization of different technologies to produce renewable fuels or useful chemicals to overcome the energy crisis, have been considered together with the recent developments in the photocatalytic reduction of CO2 by means of different titania photocatalysts to produce various energy-bearing products. The problems, progress and future prospects regarding CO2 utilization are presented. This present review indicates that the devolvement of efficient active photocatalysts for this technology is still under way and that better efficiency of the desired products could be accomplished. It is also shown that this technique is still at an embryonic stage, due to a lack of proficiency, and that the yield discrimination is very low. It can therefore be concluded that further research efforts are needed to boost this process towards commercialization in the near future
Interaction of anesthetic supplement thiopental with human serum albumin( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

A plasmid-borne blaOXA-58 gene confers imipenem resistance to Acinetobacter baumannii isolates from a Lebanese hospital by Raffaele Zarrilli( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

We investigated the basis of the carbapenem resistance of 17 multidrug-resistant Acinetobacter baumannii clinical isolates collected from 2004 to 2005 at the Saint George University Hospital in Beirut, Lebanon. A. baumannii isolates were clonally related and were susceptible to colistin and trimethoprim-sulfamethoxazole, susceptible or intermediate to ampicillin-sulbactam and meropenem, and resistant to all other antimicrobials. Conjugation experiments demonstrated that resistance to imipenem could be transferred along with a plasmid containing the carbapenem-hydrolyzing oxacillinase blaOXA-58 gene. The plasmid that we called pABIR was 29,823 bp in size and showed a novel mosaic structure composed of two origins of replication, four insertion sequence (IS) elements, and 28 open reading frames. The blaOXA-58 gene was flanked by IS18 and ISAba3 elements at the 5ʹ and 3ʹ ends, respectively. The production of the carbapenem-hydrolyzing oxacillinase OXA-58 was apparently the only mechanism
 
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Current trends in antibiotic resistance in infectious diseases
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Alternative Names
Khan, Asad Ullah.

Languages
English (13)