WorldCat Identities

Org, Elin

Overview
Works: 9 works in 13 publications in 1 language and 20 library holdings
Genres: Academic theses 
Roles: Author, Contributor, Other
Publication Timeline
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Most widely held works by Elin Org
The comparative patterns of linkage disequilibrium in European populations and its implication for genetic association studies by Elin Lõhmussaar( Book )

3 editions published in 2006 in English and held by 5 WorldCat member libraries worldwide

IL-22 paucity in APECED is associated with mucosal and microbial alterations in oral cavity by Epp Kaleviste( )

3 editions published in 2020 in English and held by 4 WorldCat member libraries worldwide

Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is caused by recessive mutations in the AIRE gene. The hallmark of the disease is the production of highly neutralizing autoantibodies against type I interferons and IL-22. Considering the importance of IL-22 in maintaining mucosal barrier integrity and shaping its microbial community, we sought to study potential changes in the oral cavity in this model of human IL-22 paucity. We found that besides known Th22 cell deficiency, APECED patients have significantly fewer circulating MAIT cells with potential IL-22 secreting capacity. Saliva samples from APECED patients revealed local inflammation, the presence of autoantibodies against IFN-[alpha] and IL-22, and alterations in the oral microbiota. Moreover, gene expression data of buccal biopsy samples suggested impaired antimicrobial response and cell proliferation, both of which are processes regulated by IL-22. Our data complement the knowledge gained from mouse models and support the concept of IL-22 being a critical homeostatic cytokine in human mucosal sites
HYPEST study: profile of hypertensive patients in Estonia by Elin Org( )

1 edition published in 2011 in English and held by 2 WorldCat member libraries worldwide

Hypervariable intronic region in NCX1 is enriched in short insertion-deletion polymorphisms and showed association with cardiovascular traits by Katrin Kepp( )

1 edition published in 2010 in English and held by 2 WorldCat member libraries worldwide

N-acetyltransferase 8, a positional candidate for blood pressure and renal regulation: resequencing, association and in silico study by Peeter Juhanson( )

1 edition published in 2008 in English and held by 2 WorldCat member libraries worldwide

Interactions between Roseburia intestinalis and diet modulate atherogenesis in a murine model by Kazuyuki Kasahara( )

1 edition published in 2018 in English and held by 2 WorldCat member libraries worldwide

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort by Elin Org( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort by Elin Org( )

1 edition published in 2017 in Undetermined and held by 1 WorldCat member library worldwide

The gut microbiome is a complex and metabolically active community that directly influences host phenotypes. In this study, we profile gut microbiota using 16S rRNA gene sequencing in 531 well-phenotyped Finnish men from the Metabolic Syndrome In Men (METSIM) study.We investigate gut microbiota relationships with a variety of factors that have an impact on the development of metabolic and cardiovascular traits. We identify novel associations between gut microbiota and fasting serum levels of a number of metabolites, including fatty acids, amino acids, lipids, and glucose. In particular, we detect associations with fasting plasma trimethylamine N-oxide (TMAO) levels, a gut microbiota-dependent metabolite associated with coronary artery disease and stroke. We further investigate the gut microbiota composition and microbiota-metabolite relationships in subjects with different body mass index and individuals with normal or altered oral glucose tolerance. Finally, we perform microbiota co-occurrence network analysis, which shows that certain metabolites strongly correlate with microbial community structure and that some of these correlations are specific for the pre-diabetic state.Our study identifies novel relationships between the composition of the gut microbiota and circulating metabolites and provides a resource for future studies to understand host-gut microbiota relationships
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits by Million Veteran Program( )

1 edition published in 2018 in English and held by 0 WorldCat member libraries worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.93 (from 0.82 for HYPEST stu ... to 1.00 for Genetic an ...)

Alternative Names
Elin Org wetenschapper

Lõhmussaar, Elin.

Languages
English (12)