WorldCat Identities

Epron, Guerric (1984-....).

Works: 1 works in 2 publications in 1 language and 1 library holdings
Roles: Author
Publication Timeline
Most widely held works by Guerric Epron
Macrophages et lymphome folliculaire : un paradoxe biologique et clinique by Guerric Epron( Book )

2 editions published in 2011 in French and held by 1 WorldCat member library worldwide

Follicular lymphoma is the most common indolent lymphoma. Patients' lifespan is around 10 years but the cancer can evolve heterogeneous ways. FL is characterized by the build-up of tumor B cells at the expense of their normal counterparts from germinal centers. It is sensitive to chemotherapy but remains largely incurable. Indeed, many relapses are observed. Descriptive studies showed that tumor-associated macrophages (TAM) are associated with poor prognosis for chemotherapy-treated patients. Unexpectedly, TAM become beneficial when the anti-CD20 antibody rituximab is added to the therapeutic regiment. In this work, we performed functional studies. We show that monocytes favor tumor growth through interleukin-15. Furthermore, follicular helper T cells, through CD40L, render tumor B cells highly sensitive to this cytokine. Nonetheless, monocytes are versatile and in vitro differentiation into macrophages allows them to phagocyte rituximab-opsonized tumor B cells. That function is also provided by in situ-purified FL TAM and involves the CD32 receptor. In the end, this study reconciles clinical observations and scientific facts. It underlines again, the importance of tumor microenvironment and gives tools for a better apprehension of macrophages ambivalent behavior in FL
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Audience level: 0.00 (from 0.00 for Macrophage ... to 0.00 for Macrophage ...)

French (2)