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Eren, Philippe (1980-....).

Works: 1 works in 2 publications in 1 language and 3 library holdings
Roles: Author
Publication Timeline
Most widely held works by Philippe Eren
Rôle des facteurs plaquettaires de la thrombose et des adipokines dans la thérapie cellulaire pro-angiogénique by Philippe Eren( Book )

2 editions published in 2010 in French and held by 3 WorldCat member libraries worldwide

We were interested in the mechanisms of neovascularization stimulated by endothelial progenitor cells (EPC). Transplantation of EPC from thé bone marrow is considered as a potential tool for cell therapy to stimulate the neovascularization of ischemic cardiovascular diseases. The main current challenge consists in better understanding the principle of action of these cells, and to optimize the benefits of cell therapy by increasing their pro-angiogenic function. Here, we chose to focus on the role of platelet factors during thrombosis and on adipocyte cytokines. We could show for the first time that platelet thrombospondine-1 (TSPI) and plasma fibrinogen (FGN) play critical and complementary roles in the recruitment of circulating EPC towards zones of thrombosis and ischemia. Conversion of FGN into deposits of fibrin provides a local substrate favorable to EPC engraftment, whereas TSPI stimulates the expression and avidity of their cell adhesion receptors. EPC recruitment operates without foiling survival or endothelial differentiation. Furthermore, we could show that the survival of the recruited EPC is conditioned by adiponectin, an adipocyte cytokine. Thus, FGN, TSPI and adiponectin are essential to the pro-angiogenic function of EPC and to the success of cell therapy in ischemic tissues. We could also suggest how our observations can be adapted to increase thé benefits of pro-angiogenic cell therapy
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WorldCat IdentitiesRelated Identities
French (2)