WorldCat Identities

Abramov, Mikhail

Overview
Works: 5 works in 5 publications in 2 languages and 7 library holdings
Genres: Juvenile works  Fairy tales  Fiction 
Roles: Narrator
Publication Timeline
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Most widely held works by Mikhail Abramov
Solution structure and conformational dynamics of deoxyxylonucleic acids (dXNA) : an orthogonal nucleic acid candidate by Mohitosh Maiti( )

1 edition published in 2012 in English and held by 2 WorldCat member libraries worldwide

"Dva klëna" : skazka : spektaklʹ Moskovskogo teatra I︠U︡nogo zriteli︠a︡ by Evgeniĭ Shvart︠s︡( Recording )

1 edition published in 2014 in Russian and held by 2 WorldCat member libraries worldwide

A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity by Jesper B Bramsen( )

1 edition published in 2010 in English and held by 1 WorldCat member library worldwide

Modulation of BACE1 Activity by Chemically Modified Aptamers( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: A modified DNA aptamer that binds BACE1, a therapeutic target involved in Alzheimer's disease has been developed. This ssXNA not only tightly binds to BACE1 but also inhibits its protease activity in vitro in the same range as a previously described unmodified aptamer. We report the in vitro selection of functional oligonucleotides incorporating two nucleobase modifications: 5-chlorouracil and 7-deazaadenine. The nucleoside analogue 5-chloro-2′-deoxyuridine has already been explored as a replacement for thymidine in a chemically modified genome of a bacterium. Thus, 5-chlorouracil modification is a good candidate to support genetic transfer in vivo as well as functional activity. Abstract : Xenonucleic acids--a good thymine substitute : SELEX was used to select an aptamer that binds and inhibits, but also activates, BACE1, a therapeutic target in Alzheimer's disease, in a concentration-dependent manner. This aptamer was obtained by using 5-chloro-dUTP in place of dTTP during the selection process, opening a way to a new xenobiotic
 
Audience Level
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Audience Level
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  Kids General Special  
Audience level: 0.76 (from 0.39 for "Dva klën ... to 0.96 for A large-sc ...)

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