WorldCat Identities

Fujikawa, Akihiro

Overview
Works: 4 works in 4 publications in 2 languages and 5 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Akihiro Fujikawa
Targeting PTPRZ inhibits stem cell-like properties and tumorigenicity in glioblastoma cells by Akihiro Fujikawa( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Nijunenrai no ube kingo igokai( Book )

1 edition published in 1998 in Japanese and held by 1 WorldCat member library worldwide

Adipsic hypernatremia without hypothalamic lesions accompanied by autoantibodies to subfornical organ( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Abstract: Adipsic (or essential) hypernatremia is a rare hypernatremia caused by a deficiency in thirst regulation and vasopressin release. In 2010, we reported a case in which autoantibodies targeting the sensory circumventricular organs (sCVOs) caused adipsic hypernatremia without hypothalamic structural lesions demonstrable by magnetic resonance imaging (MRI); sCVOs include the subfornical organ (SFO) and organum vasculosum of the lamina terminalis (OVLT), which are centers for the monitoring of body-fluid conditions and the control of water and salt intakes, and harbor neurons innervating hypothalamic nuclei for vasopressin release. We herein report three newly identified patients (3- to 8-year-old girls on the first visit) with similar symptoms. The common features of the patients were extensive hypernatremia without any sensation of thirst and defects in vasopressin response to serum hypertonicity. Despite these features, we could not detect any hypothalamic structural lesions by MRI. Immunohistochemical analyses using the sera of the three patients revealed that antibodies specifically reactive to the mouse SFO were present in the sera of all cases; in one case, the antibodies also reacted with the mouse OVLT. The immunoglobulin (Ig) fraction of serum obtained from one patient was intravenously injected into wild-type mice to determine whether the mice developed similar symptoms. Mice injected with a patient's Ig showed abnormalities in water/salt intake, vasopressin release, and diuresis, which resultantly developed hypernatremia. Prominent cell death and infiltration of reactive microglia was observed in the SFO of these mice. Thus, autoimmune destruction of the SFO may be the cause of the adipsic hypernatremia. This study provides a possible explanation for the pathogenesis of adipsic hypernatremia without demonstrable hypothalamus-pituitary lesions
Nishikawa sadaichi sensei no genkōroku : Jushii kunnitō zuihōshō jushō : Nishikawa sensei no 20kaiki ni omō( Book )

1 edition published in 2010 in Japanese and held by 1 WorldCat member library worldwide

 
Audience Level
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Audience Level
1
  General Special  
Audience level: 0.95 (from 0.88 for Adipsic hy ... to 0.97 for Targeting ...)

Alternative Names
Fujikawa, Akihiro

フジカワ, アキヒロ

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