WorldCat Identities

Eriksson, Anna 1977-

Overview
Works: 3 works in 4 publications in 1 language and 4 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Anna Eriksson
Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia by Anna Eriksson( Book )

2 editions published in 2012 in English and held by 2 WorldCat member libraries worldwide

Towards repositioning of quinacrine for treatment of acute myeloid leukemia - Promising synergies and in vivo effects by Anna Eriksson( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

We previously reported that the anti-malarial drug quinacrine has potential to be repositioned for treatment of acute myeloid leukemia (AML). As a next step towards clinical use, we assessed the efficacy of quinacrine in an AML-PS mouse model and investigated possible synergistic effects when combining quinacrine with nine other antileukemic compounds in two AML cell lines. Furthermore, we explored the in vivo activity of quinacrine in combination with the widely used AML agent cytarabine. The in vivo use of quinacrine (100mg/kg three times per week for two consecutive weeks) significantly suppressed circulating blast cells at days 30/31 and increased the median survival time (MST). The in vitro drug combination analysis yielded promising synergistic interactions when combining quinacrine with cytarabine, azacitidine and geldanamycin. Finally, combining quinacrine with cytarabine in vivo showed a significant decrease in circulating leukemic blast cells and increased MST compared to the effect of either drug used alone, thus supporting the findings from the in vitro combination experiments. Taken together, the repositioning potential of quinacrine for treatment of AML is reinforced by demonstrating significant in vivo activity and promising synergies when quinacrine is combined with different agents, including cytarabine, the hypomethylating agent azacitidine and HSP-90 inhibitor geldanamycin
AKN-028 induces cell cycle arrest, downregulation of Myc associated genes and a dose dependent reduction of kinase activity in acute myeloid leukemia by Anna Eriksson( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

AKN-028 is a novel tyrosine kinase inhibitor with preclinical activity in acute myeloid leukemia (AML), presently undergoing investigation in a phase I/II study. It is a potent inhibitor of the FMS-like kinase 3 (FLT3) but shows in vitro activity in a wide range of AML samples. In the present study, we have characterized the effects of AKN-028 on AML cells in more detail. AKN-028 induced a dose-dependent G(0)/arrest in AML cell line MV4-11. Treatment with AKN-028 caused significantly altered gene expression in all AML cell types tested (430 downregulated, 280 upregulated transcripts). Subsequent gene set enrichment analysis revealed enrichment of genes associated with the proto-oncogene and cell cycle regulator c-Myc among the downregulated genes in both AKN-028 and midostaurin treated cells. Kinase activity profiling in AML cell lines and primary AML samples showed that tyrosine kinase activity, but not serine/threonine kinase activity, was inhibited by AKN-028 in a dose dependent manner in all samples tested, reaching approximately the same level of kinase activity. Cells sensitive to AKN-028 showed a higher overall tyrosine kinase activity than more resistant ones, whereas serine/threonine kinase activity was similar for all primary AML samples. In summary, AKN-028 induces cell cycle arrest in AML cells, downregulates Myc-associated genes and affect several signaling pathways. AML cells with high global tyrosine kinase activity seem to be more sensitive to the cytotoxic effect of AKN-028 in vitro
 
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Alternative Names
Anna Eriksson

Anna Eriksson cantante finlandesa

Anna Eriksson chanteuse finnoise

Anna Eriksson en finländsk sångare

Anna Eriksson finnische Schlagersängerin

Anna Eriksson Finnish singer

Anna Eriksson Fins zangeres

Anna Eriksson singer

Anna Sofia Eriksson

Eriksson, Anna Sofia

Eriksson, Anna Sofia 1977-

Анна Эрикссон

آنا أريكسون مغنية فنلندية

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