WorldCat Identities

Foresta, Carlo

Overview
Works: 36 works in 39 publications in 2 languages and 75 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Carlo Foresta
Testis cancer: Genes, environment, hormones by Carlo Foresta( Book )

1 edition published in 2015 in Undetermined and held by 28 WorldCat member libraries worldwide

Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last decades. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. This recent evidence expands the current knowledge on the role of genetic contribution in testicular cancer susceptibility, and supports the hypothesis that variations in hormone metabolism genes might change the hormonal environment implicated in testicular carcinogenesis. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to genetic factors influencing hormone-related cancer risk. The genetic component to TGCT is in general strong. In fact, although environmental factors clearly contribute to TGCT development (and probably to its increasing incidence in some geographical areas), the proportion of TGCT susceptibility accounted for by the genetic effects is estimated at 25%. TGCT has high familial risks compared with most other cancer types that are generally no more than two-fold: brothers of individuals with TGCT have an 8- to 12-fold increased risk of disease, and sons of affected individuals have a 4- to 6-fold increased risk. Despite this strong familial relative risk, early results from linkage studies identified a limited relationship with genetic factors, suggesting that TGCT is a genetically complex trait. However, more recently, four genome-wide association studies (GWAS) from the UK and USA have reported association of TGCTs with six new loci (KITLG, SPRY4, BAK1, DMRT1, TERT, and ATF7IP). The strongest association for TGCT susceptibility was found for SNPs in KITLG (ligand for the membrane-bound receptor tyrosine kinase KIT) gene with a greater than 2.5-fold increased risk of disease per major allele, which is the highest reported for any cancer to date. These studies are being
La medicina della riproduzione by Carlo Foresta( Book )

3 editions published between 2000 and 2002 in Italian and held by 4 WorldCat member libraries worldwide

Fisiopatologia delle funzioni gonadiche by Carlo Foresta( Book )

2 editions published in 2001 in Italian and held by 3 WorldCat member libraries worldwide

Citologia testicolare per agoaspirazione nella diagnostica dell'infertilita maschile by Carlo Foresta( Book )

1 edition published in 1993 in Italian and held by 3 WorldCat member libraries worldwide

Andrologia e riproduzione by Carlo Foresta( Book )

1 edition published in 2004 in Italian and held by 2 WorldCat member libraries worldwide

La medicina della riproduzione : dalla sperimentazione alla clinica( Book )

1 edition published in 2011 in Italian and held by 2 WorldCat member libraries worldwide

Riproduzione, sessualita e diversità di genere( Book )

1 edition published in 2008 in Italian and held by 2 WorldCat member libraries worldwide

Basic approach to clinical pathology : for medical students by Carlo Foresta( Book )

1 edition published in 2009 in English and held by 2 WorldCat member libraries worldwide

La riproduzione umana e le influenze ambientali by Carlo Foresta( Book )

1 edition published in 2006 in Italian and held by 2 WorldCat member libraries worldwide

Eiaculazione precoce : fisiopatologia clinica e trattamento by Carlo Foresta( Book )

1 edition published in 2010 in Italian and held by 1 WorldCat member library worldwide

Gli scenari della fertilità umana tra ambiente e società( Book )

1 edition published in 2014 in Italian and held by 1 WorldCat member library worldwide

Infertilità maschile : fisiopatologia, clinica, diagnostica e terapia : manuale di consultazione by Carlo Foresta( Book )

1 edition published in 2009 in Italian and held by 1 WorldCat member library worldwide

Infertilità maschile: orientamenti diagnostici( Book )

1 edition published in 1998 in Italian and held by 1 WorldCat member library worldwide

Atti del 3. congresso della Società italiana di fisiopatologia della riproduzione by Società italiana di fisiopatologia della riproduzione( Book )

1 edition published in 1988 in Italian and held by 1 WorldCat member library worldwide

La riproduzione maschile : fisiopatologia e clinica by Carlo Foresta( Book )

1 edition published in 1999 in Italian and held by 1 WorldCat member library worldwide

Le alterazioni gonadiche : aspetti fisiologici e clinici by Carlo Foresta( Book )

1 edition published in 2005 in Italian and held by 1 WorldCat member library worldwide

Fisiopatologia della riproduzione : atti del 3. Congresso Nazionale della Societa Italiana di fisiopatologia della riproduzione by Congresso Nazionale della Societa Italiana di fisiopatologia della riproduzione( Book )

1 edition published in 1988 in Italian and held by 1 WorldCat member library worldwide

Sperm recovery and ICSI outcomes in Klinefelter syndrome: a systematic review and meta-analysis( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract BACKGROUND Specific factors underlying successful surgical sperm retrieval rates (SRR) or pregnancy rates (PR) after testicular sperm extraction (TESE) in adult patients with Klinefelter syndrome (KS) have not been completely clarified. OBJECTIVE AND RATIONALE The aim of this review was to meta-analyse the currently available data from subjects with KS regarding SRRs as the primary outcome. In addition, when available, PRs and live birth rates (LBRs) after the ICSI technique were also investigated as secondary outcomes. SEARCH METHODS An extensive Medline, Embase and Cochrane search was performed. All trials reporting SRR for conventional-TESE (cTESE) or micro-TESE (mTESE) and its specific determinants without any arbitrary restriction were included. OUTCOMES Out of 139 studies, 37 trials were included in the study, enrolling a total of 1248 patients with a mean age of 30.9 ± 5.6 years. The majority of the studies (n = 18) applied mTESE, 13 applied cTESE and in one case testicular sperm aspiration (TESA) was used. Additionally, four studies used a mixed approach and in one study, the method applied for sperm retrieval was not specified. Overall, a SRR per TESE cycle of 44[39;48]% was detected. Similar results were observed when mTESE was compared to cTESE (SRR 43[35;50]% vs 45[38;52]% for cTESE vs micro-TESE, respectively; Q = 0.20, P = 0.65). Meta-regression analysis showed that none of the parameters tested, including age, testis volume and FSH, LH and testosterone (T) levels at enrollment, affected the final SRR. Similarly, no difference was observed when a bilateral procedure was compared to a unilateral approach. No sufficient data were available to evaluate the effect of previous T treatment on SRR. Information on fertility outcome after ICSI was available for 29 studies. Overall a total of 218 biochemical pregnancies after 410 ICSI cycles were observed (PR = 43[36;50]%). Similar results were observed when LBR was analyzed (LBR = 43[34;53]%). Similar to what was observed for SRR, no influence of KS age, mean testis volume, LH, FSH or total T levels on either PR and LBR was observed. No sufficient data were available to test the effect of the women's age or other female fertility problems on PR and LBR. Finally, no difference in PR or LBR was observed when the use of fresh sperm was compared to the utilization of cryopreserved sperm. WIDER IMPLICATIONS The present data suggest that performing TESE/micro-TESE in subjects with KS results in SRRs of close to 50%, and then PRs and LBRs of close to 50%, with the results being independent of any clinical or biochemical parameters tested
Iter terapeutico della coppia infertile : consensus( Book )

1 edition published in 2005 in Italian and held by 1 WorldCat member library worldwide

 
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Audience Level
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  Kids General Special  
Audience level: 0.79 (from 0.58 for Testis can ... to 0.98 for Citologia ...)

Alternative Names
Carlo Foresta Italiaans arts

Carlo Foresta medico (1951-), docente di patologia clinica presso l'Università di Padova. Direttore della Fondazione Foresta

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