WorldCat Identities

Grosse, Sandrine

Overview
Works: 5 works in 5 publications in 2 languages and 7 library holdings
Roles: Contributor, Opponent, Author
Publication Timeline
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Most widely held works by Sandrine Grosse
Detrimental effect of the 6 His C-terminal tag on YedY enzymatic activity and influence of the TAT signal sequence on YedY synthesis by Monique Sabaty( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Efficient C-7 or C-3/C-7 Direct Arylation of Tri- or Disubstituted Imidazo[1,2-b]pyrazoles( )

1 edition published in 2013 in English and held by 2 WorldCat member libraries worldwide

Vers la synthèse d'analogues amidiques de dinucléotides cycliques, potentiels agents antibactériens, antiviraux et anticancéreux by Krystal Gaillard( )

1 edition published in 2021 in French and held by 1 WorldCat member library worldwide

Cyclic dinucleotides (CDNs) are natural molecules, found in bacteria and eukaryote cells. In bacteria, they are mainly secondary chemical messengers which can regulate diverse biological processes such as biofilm formation. In eukaryote cells, the natural CDNs bonding with the STING protein stimulates antipathogenic signaling pathways. Chemical modifications of CDNs can be considered so as to grant a resistance against phosphodiesterases while maintaining the affinity of these cyclic molecules towards the target biological systems. Diverse modifications are reported in literature, including the modification of the internucleosidic linkage. More specifically, this phosphodiester linkage can be replaced by an amide linkage. Various synthetic pathways were explored in literature to access these CDNs amidic analogues. The aim of this thesis work is the synthesis of a constrained bicyclic analogue comprising the amide linkage. To accomplish this, we established two synthetic pathways to obtain the bicyclic dinucleoside. The first pathway consists in forming the cyclic dimer then bonding the alkenylated amide functions via a metathesis reaction. The second pathway consists in preparing a linear N-allylated dimer, then forming the bicyclic dinucleoside by a succession of metathesis and macrolactamization. Several reaction steps such as the amide and carbamate alkylations, the metathesis and the peptidic couplings required synthetic adjustments
Imidazo[1, 2-b]pyrazoles, imidazo[1, 2-a]imidazoles : synthèse, fonctionnalisation et évaluation biologique by Sandrine Grosse( )

1 edition published in 2013 in French and held by 1 WorldCat member library worldwide

Les imidazo[1,2-b]pyrazoles tout comme les imidazo[1,2-a]imidazoles sont des entités présentant diverses applications intéressantes notamment dans le domaine pharmacologique. Cependant, malgré ce potentiel, ces structures hétérobicycliques ont été, jusqu'à ce jour, relativement peu étudiées tant au niveau de leur préparation que de leur fonctionnalisation. De ce fait, ces travaux de thèse ont pour objet la mise au point de nouvelles voies d'accès à ces systèmes bicycliques et ce, au départ de substrats facilement accessibles. Des stratégies de fonctionnalisation de ces charpentes moléculaires ont ensuite été développées dans le but de concevoir des librairies diversifiées de ce type de composés, librairies destinées à être évaluées biologiquement. Les premiers résultats d'évaluation sur des lignées cancéreuses de dérivés imidazo[1,2-b]pyrazoliques sont également présentés
Synthèse de nouveaux hétérocycles azotés non aromatiques de type amidrazone et étude de leurs réactivités by Johann Leblanc( )

1 edition published in 2022 in French and held by 1 WorldCat member library worldwide

Nitrogen heterocycles are omnipresent as essential building blocks of lots of chemical compounds in living organisms. In medicinal chemistry, their predominance reflects the challenge of developing innovative synthesis strategies in order to expand the diversity of Nheterocyclic compounds in the chemical space and for instance, improving the biological activity of drugs. The 1,4,5,6-tetrahydro-1,2,4-triazines, or cyclic amidrazones, have not been explored much until today. First of all, the aims of this research work consist in developing and optimising the synthesis of cyclic amidrazones, and subsequently studying their reactivity through various reactions such as alkylation reactions, acylations or metallo-catalysed cross coupling reactions. Finally, these results allow access to new cyclic amidrazones and to versatile functionalisation of each of their positions
 
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