WorldCat Identities

Chopra, Madhu

Overview
Works: 5 works in 13 publications in 1 language and 102 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author
Classifications: RS403, 615.19
Publication Timeline
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Most widely held works by Madhu Chopra
Medicinal chemistry by V. K Ahluwalia( Book )

8 editions published in 2008 in English and held by 96 WorldCat member libraries worldwide

"This book is primarily intended for the students and professionals in the pharmaceutical industry. Assuming little prior knowledge of the subject, the book gives a concise introduction to the chemistry of therapeutically active compounds. It also includes a brief discussion on drug development from the discovery to research stage leading to final product."--Jacket
Boundary element technology XIV by Boundary element technology in engineering (International conference)( )

2 editions published in 2001 in English and held by 3 WorldCat member libraries worldwide

Annotation
STORMS AND TORNADOES : weather hazards by M CHOPRA( Book )

1 edition published in 2020 in English and held by 1 WorldCat member library worldwide

Methyl-accepting chemotaxis like Rv3499c (Mce4A) protein in Mycobacterium tuberculosis H37Rv mediates cholesterol-dependent survival( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract: Cholesterol, an essential cellular component in macrophages, is exploited for entry and long-term survival of Mycobacterium inside the host. Cholesterol-deficient macrophages can restrict the cholesterol-dependent entry of Mycobacterium . Rv3499c protein in Mycobacterium has high binding affinity for cholesterol. Rv3499c gene is a part of mce4 operon which is reported to act as cholesterol transport system in mycobacteria. Earlier we reported Rv3499c protein to localise on cell wall and facilitate entry of Mycobacterium inside macrophages. Here we performed fold recognition and multiple sequence alignment to find similarity with methyl-accepting chemotaxis protein (MCP). MCP allows detection of level of nutrient in the medium, which in this case is cholesterol. We showed Rv3499c protein expression is important for host cholesterol utilization by Mycobacterium for its survival. Infected female balb/c mice presented increased CFU of Rv3499c overexpressing M. tuberculosis H37Rv marked with early disease conditions and increased lung pathology. Thus, findings suggest specific domain of MCP of Rv3499c help in regulation of downstream PDIM synthesis pathways for ligand utilization by M. tuberculosis H37Rv
Selective duodenography for controlled first-pass bolus distention of the duodenum in neonates and young children with bile-stained vomiting( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Abstract : Aim: To compare "selective duodenograms" performed through nasogastric tubes advanced into the proximal duodenum against traditional contrast studies regarding visualisation of a first-pass bolus distention of the duodenum and frequency of inconclusive results. Materials and methods: Retrospective comparison of "selective duodenograms" and traditional upper gastrointestinal contrast studies in neonates with bile-stained vomiting, regarding demonstration of the duodenal C-loop, first-pass bolus capture, degree of distention of the duodenum, and number of inconclusive studies. Statistical comparison was performed using the two-tailed Fishers exact and chi-squared tests. Results: There were 31 "selective duodenograms" and 70 traditional studies. The C-loop was demonstrated in 93% of traditional studies versus 100% in "selective duodenograms" and was demonstrated significantly more often during the first-pass (94% versus 73%; p =0.018) and more often with distention of the duodenum for "selective duodenography" (94% versus 56%, p <0.001). There were more inconclusive traditional studies (7% versus 3%; non-significant). Conclusion: Emergency upper gastrointestinal tract studies performed in neonates using the "selective duodenogram" technique demonstrated the duodenum with 100% success, with significantly more frequent first-pass bolus visualisation and duodenal distention than traditional studies. The five (7%) inconclusive traditional studies, present a significant diagnostic conundrum in the emergency setting because emergency surgery must be contemplated without proof. Highlights: Neonatal upper GI studies determine the need for surgery in suspected malrotation. Reliance on gravity for first-pass bolus distention depends on luck. Advancing a NGT into the duodenum is easy in new-born gastric anatomy. Selective duodenography is virtually fool-proof in demonstrating anatomy. Duodenal distention on the first pass bolus can be timed and captured
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.68 (from 0.67 for Medicinal ... to 0.89 for Selective ...)

Medicinal chemistry
Covers
Alternative Names
Chopra, M.

Madhu Chopra.

Languages
English (13)