WorldCat Identities

Delaude, Lionel

Overview
Works: 6 works in 6 publications in 2 languages and 11 library holdings
Roles: Other, Contributor
Publication Timeline
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Most widely held works by Lionel Delaude
Coupling and Carbonylation of Iodoaromatics and Terminal Alkynes or Alkynols Catalyzed by a Dimeric Palladium Hydroxide( )

1 edition published in 2002 in English and held by 2 WorldCat member libraries worldwide

Microwave-Assisted Synthesis of N-Heterocyclic Carbene Precursors( )

1 edition published in 2006 in English and held by 2 WorldCat member libraries worldwide

Les Strychnos africains et leurs alcaloïdes by Clément Delaude( Book )

1 edition published in 1997 in French and held by 2 WorldCat member libraries worldwide

Recent Advances in Small Clusters and Polymetallic Assemblies Based on Transition Metals and Dithiocarboxylate Zwitterions Derived from N-Heterocyclic Carbenes by Tomás F Beltrán( )

1 edition published in 2017 in English and held by 2 WorldCat member libraries worldwide

Synthèse de complexes originaux de ruthénium(II) à base de ligands étendus dérivés de phénanthroline, caractérisation photophysique et propriétés d'interaction avec les G-quadruplexes by Dounia Saadallah( )

1 edition published in 2016 in French and held by 2 WorldCat member libraries worldwide

The interest for some unusual structures of DNA, the G4 quadruplexes was growing these past few years. Those structures were extensively studied in vitro, but a lot remains unkwown about their existence in vivo. Intererstingly, G4 structures seem to play key regulatory roles in gene expression and are therefore potential therapeutic targets for diseases such as cancer. Consequently, visualisation of those structures in cells is the present challenge today, and the use of small molecules with luminescent properties is promising in this context.In this framework, we designed a series of new rutheniumII complexes chelating a large planar aromatic ligand, (heptacycle dpqp or octacycle dppqp). The combination of the photophysical properties of RuII complexes with proposed favorable stacking properties of the ligand with G4, would make these complexes promising molecular tools for G4 visualization.The first part of this project focusses on the synthesis of ruthenium complexes and their specific ligands. One particular ligand is formed by the condensation between acridine and phenanthroline moieties. A chemistry on the complex approach enabled us 1) to functionnalize the chelated ligand by a triple bond that will be used for the formation of an heterodimer by click chemistry, and 2) to build an additional cycle on the chelated ligand. Photophysical properties were evaluated and only two complexes, [Ru(phen)2dpqp-Cl]2+ and [Ru(TAP)2dpqp-Cl]2+, exhibit the same photophysical behaviour than the reference complexes. Indeed, the quantum yields are in the same order of magnitude than for [Ru(bpy)3]2+ and the excited state lifetime are of a few hundred nanosecondes. The other complexes are non-luminescent and a quenching by excited state proton transfer was hypothesised to explain this unusual behaviour. Interaction properties with G4 DNA were evaluated. All complexes display good affinity towards G4 and as expected, the complexe bearing the octacyclic ligand shows a strong selectivity towards G4 compared to dsDNA. Two of the complexes were proven to be potential luminescent light-switch ON probes for G4 detection in cells. In conclusion, this work highlights the possibility to use some of the newly synthetized complexes as efficient molecular tools for G4 visualization in cells
Synthesis of ruthenium complexes having one or more N-heterocyclic carbene ligands supported on hybrid mesostructured silicas and their use in the hydrogenation of carbon dioxide by Mathieu Baffert( )

1 edition published in 2011 in English and held by 1 WorldCat member library worldwide

The goal of this PhD was to elaborate supported Ru-NHC catalytic materials based on hybrid organic-inorganic materials having imidazolium units perfectly distributed within a silica matrix. Passivation of these imidazolium materials followed by formation of NHC-carbene and reaction with [RuCl2(p-cymene)]2 provided these well-defined surface sites of general structures RuCl2(NHC)(L), where L was para-cymene (p-cymene) or THF depending on the reaction conditions, which could be further replaced by PMe3. These systems were then tested in the hydrogenation of CO2 in presence of amine to give formamides. The mono-NHC systems were highly active only in the presence of PMe3 ligands, but suffered from Ru leaching, evidencing the low stability of the NHC-Ru bond under the reaction conditions. On the other hand, dinuclear bis-NHC Ru systems were also developed, and they displayed much improved activity and stability in the hydrogenation of CO2 in the presence of PMe3 compared to the mono-NHC systems. This allowed the use of much higher reaction temperatures (200 °C) and provided heterogeneous catalysts with performances close to those obtained with the best homogeneous catalysts, Cl2Ru(dppe)2
 
Audience Level
0
Audience Level
1
  General Special  
Audience level: 0.96 (from 0.92 for Les Strych ... to 0.97 for Synthèse ...)

Alternative Names
Lionel Delaude researcher

Lionel Delaude wetenschapper

Languages