WorldCat Identities

Bogucka, Katarzyna 1989-

Overview
Works: 2 works in 2 publications in 1 language and 6 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Katarzyna Bogucka
Role of ERK3 in the regulation of IL-8 and epithelial secretome-mediated chemotaxis by Katarzyna Bogucka( )

1 edition published in 2019 in English and held by 3 WorldCat member libraries worldwide

ERK3/MAPK6 controls IL-8 production and chemotaxis by Katarzyna Bogucka( )

1 edition published in 2020 in English and held by 3 WorldCat member libraries worldwide

Abstract: ERK3 is a ubiquitously expressed member of the atypical mitogen activated protein kinases (MAPKs) and the physiological significance of its short half-life remains unclear. By employing gastrointestinal 3D organoids, we detect that ERK3 protein levels steadily decrease during epithelial differentiation. ERK3 is not required for 3D growth of human gastric epithelium. However, ERK3 is stabilized and activated in tumorigenic cells, but deteriorates over time in primary cells in response to lipopolysaccharide (LPS). ERK3 is necessary for production of several cellular factors including interleukin-8 (IL-8), in both, normal and tumorigenic cells. Particularly, ERK3 is critical for AP-1 signaling through its interaction and regulation of c-Jun protein. The secretome of ERK3-deficient cells is defective in chemotaxis of neutrophils and monocytes both in vitro and in vivo. Further, knockdown of ERK3 reduces metastatic potential of invasive breast cancer cells. We unveil an ERK3-mediated regulation of IL-8 and epithelial secretome for chemotaxis
 
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Audience Level
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Audience level: 0.00 (from 0.00 for ERK3/MAPK6 ... to 0.00 for ERK3/MAPK6 ...)

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Alternative Names
Katarzyna Bogucka onderzoeker

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