Front cover image for Effects of Design Factors and Microenvironment on Mesenchymal Stem Cells and Nucleus Pulposus Cells for Intervertebral Disc Tissue Engineering

Effects of Design Factors and Microenvironment on Mesenchymal Stem Cells and Nucleus Pulposus Cells for Intervertebral Disc Tissue Engineering

Intervertebral disc degeneration is a common and significant health concern that often leads to low back pain and worker disability. Disc degeneration is often irreversible, and current treatments do not adequately restore cell health or biomechanical function. Tissue engineering strategies are a possible solution to regenerate disc matrix, but one challenge for regenerating tissue is the degenerative disc microenvironment, which is characterized by inflammation, hypoxia, low glucose, low pH, and high osmolality. This research focuses on the effect of design factors on tissue-engineered constructs in the context of the disc microenvironment
Thesis, Dissertation, English, 2017
University of California, San Francisco, San Francisco, 2017
University of California, San Francisco