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A Multi-Omics Epidemiologic Study of Alzheimer’s disease: Een multi-omics epidedemiologische studie van de ziekte van Alzheimer

Author: Shahzad Ahmad
Publisher: Erasmus University Rotterdam 2020-10-01
Edition/Format: Book Book : English
Summary:
Alzheimer’s disease (AD) is a devastating neurodegenerative disease that accounts for more than 70% of worldwide dementia cases. The rising AD prevalence in aging populations is posing a substantial economic and health challenge. Unfolding the events leading to the development of AD may guide drug and preventive treatment research. Recent advances in multi-omics technology enable us to disentangle the molecular  Read more...
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Document Type: Book
All Authors / Contributors: Shahzad Ahmad
ISBN: 978-94-6380-939-9
Language Note: English
Unique Identifier: 8680845422
Awards:

Abstract:

Alzheimer’s disease (AD) is a devastating neurodegenerative disease that accounts for more than 70% of worldwide dementia cases. The rising AD prevalence in aging populations is posing a substantial economic and health challenge. Unfolding the events leading to the development of AD may guide drug and preventive treatment research. Recent advances in multi-omics technology enable us to disentangle the molecular mechanism underlying AD pathophysiology. I have used multi-omics layers to enhance further our understanding of the molecular pathways underlying AD risk and pathophysiology. In this thesis, I identified biological pathways that may contribute to early AD pathology. I also evaluated the role of proteins and metabolites in the circulation and their interaction with AD risk genes. I found elevated levels of the HAGH and CDH6 proteins in blood in pre-dementia cases in the Rotterdam Study, and findings were replicated in an independent cohort. Findings from this thesis also underscore the role of signaling lipids in the pathophysiology of AD. Finally, this thesis provides new insight into the determinants of the gut-liver-brain axis in AD.

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Primary Entity<\/h3>\n
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Related Entities<\/h3>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Agent\/erasmus_university_rotterdam<\/a>> # Erasmus University Rotterdam<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:Agent<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Erasmus University Rotterdam<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Person\/ahmad_shahzad<\/a>> # Shahzad Ahmad<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Shahzad Ahmad<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/alzheimer_s_disease<\/a>> # Alzheimer\'s disease<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Alzheimer\'s disease<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/epidemiology<\/a>> # epidemiology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"epidemiology<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/genetic_risk_score<\/a>> # genetic risk score<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"genetic risk score<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/genomics<\/a>> # genomics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"genomics<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/gut_liver_brain_axis<\/a>> # gut-liver-brain axis<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"gut-liver-brain axis<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/metabolomics<\/a>> # metabolomics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"metabolomics<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/multi_omics<\/a>> # multi-omics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"multi-omics<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/pathways<\/a>> # pathways<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"pathways<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/proteomics<\/a>> # proteomics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"proteomics<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10593802246#Thing\/signaling_lipids<\/a>> # signaling lipids<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"signaling lipids<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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Content-negotiable representations<\/p>\n