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Accounts in drug discovery : case studies in medicinal chemistry

Author: Joel Charles Barrish; Royal Society of Chemistry (Great Britain)
Publisher: Cambridge : RSC Publishing, 2010.
Series: RSC drug discovery series, 4.
Edition/Format:   Print book : EnglishView all editions and formats

Accounts in Drug Discovery describes recent case studies in medicinal chemistry with a particular emphasis on how the inevitable problems that arise during any project can be surmounted or overcome.


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Genre/Form: Case studies
Document Type: Book
All Authors / Contributors: Joel Charles Barrish; Royal Society of Chemistry (Great Britain)
ISBN: 9781849731263 1849731268
OCLC Number: 651078257
Description: xvi, 379 pages : illustrations ; 24 cm.
Contents: The discovery of the dipeptidyl peptidase-4 (DPP4) inhibitor Onglyza : from concept to market / Jeffrey A. Robl and Lawrence G. Hamann --
The discovery of Vorapaxar (SCH 530348), a thrombin receptor (protease activated receptor-1) antagonist with potent antiplatelet effects / Samuel Chackalamannil --
The discovery of Piragliatin, a glucokinase activator / Ramakanth Sarabu, Jefferson W. Tilley and Joseph Grimsby --
The discovery of OSI-906, a small-molecule inhibitor of the insulin-like growth factor-1 and insulin receptors / Mark J. Mulvihill and Elizabeth Buck --
The genesis of the antibody conjugate gemtuzumab ozogamicin (Mylotarg®) for acute myeloid leukemia / Philip R. Hamann --
Novel androgen receptor antagonists for the treatment of prostate cancer / Ashvinikumar V. Gavai, William R. Foster, Aaron Balog and Gregory D. Vite --
The discovery of UK-390957 : the challenge of targeting a short half-life, rapid Tmax SSRI / Mark D. Andrews and Donald S. Middleton --
The discovery of the long-acting PDE5 inhibitor PF-489791 for the treatment of pulmonary hypertension / Andrew S. Bell and Michael J. Palmer --
From HTS to market : the discovery and development of maraviroc, a CCR5 antagonist for the treatment of HIV / Chris Barber and David Pryde --
The discovery of GS-9131, an amidate prodrug of a novel nucleoside phosphate HIV reverse transcriptase inhibitor / Richard Mackman --
2'-F-2'-C-methyl nucleosides and nucleotides for the treatment of hepatitis C virus : from discovery to the clinic / Michael J. Sofia, Phillip A. furman and William T. Symonds --
A case history on the challenges of central nervous system and dual pharmacology drug discovery / Paul V. Fish, Anthony Harrison, Florian Wakenhut and Gavin A. Whitlock --
The discovery of TRPV1 antagonists : turning up the heat / Mark H. Norman --
Uncoupling neuroprotection from immunosuppression : the discovery of ILS-920 / Edmund I. Graziani --
Identification of [alpha] 7 nicotinic acetylcholine receptor agonists for their assessment in improving cognition in schizophrenia / Bruce N. Rogers [and others].
Series Title: RSC drug discovery series, 4.
Responsibility: edited by Joel C. Barrish [and others].


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oThis book is expensive but highly informative, with useful illustrations, some in color, and a 17 page index. It could serve as a text for a seminar course for graduate students and postdocs or for Read more...

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