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ACE Inhibitors

Author: Pedro D'Orléans-Juste; G E Plante
Publisher: Basel : Birkhäuser Basel : Imprint : Birkhäuser, 2001.
Series: Milestones in Drug Therapy MDT.
Edition/Format:   eBook : Bibliographic data : EnglishView all editions and formats
Summary:
The therapeutic use of angiotensin converting enzyme (ACE) inhibitors is subject of this monograph, written by international experts in the field. Elegantly introduced by a historical perspective by Sir John Vane, Nobel Laureate, the book covers major topics ranging from the molecular basis of the ACE inhibitors to their application in several diseases of paramount importance such as hypertension, renal failure,  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Bibliographic data, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Pedro D'Orléans-Juste; G E Plante
ISBN: 9783034875790 3034875797 9783034875813 3034875819
OCLC Number: 840290213
Description: 1 online resource (x, 187 pages)
Contents: The history of inhibitors of angiotensin converting enzyme --
Genetics of the renin-angiotensin-aldosterone system and risk of arterial disease --
Crosstalk between ACE inhibitors, B2 kinin receptor and nitric oxide in endothelial cells --
Interactions between the ACE and the endothelin pathway --
Evaluative and epidemiological approaches of ACE therapy --
The role of ACE inhibition in heart failure --
Angiotensin converting enzyme inhibition in the microcirculation --
Arterial structure and function and blockade of the reninangiotensin system in hypertension --
The contribution of angiotensin-converting enzyme (ACE) to the metabolism of kinins (bradykinin and des-Arg9-bradykinin) and effect of ACE inhibitors on their in vitro and in vivo metabolism --
Role of the renin-angiotensin system on the central and peripheral autonomic nervous system --
Dual inhibitors of angiotensin converting enzyme and neutral endopeptidase --
Pharmacodynamics, tissue-specificity of ACE inhibitors --
Effect of angiotensin converting enzyme inhibition on thirst and salt-appetite --
ACE and diabetes.
Series Title: Milestones in Drug Therapy MDT.
Responsibility: edited by Pedro D'Orléans-Juste, Gérard E. Plante.

Abstract:

The therapeutic use of angiotensin converting enzyme (ACE) inhibitors is subject of this monograph, written by international experts in the field. Elegantly introduced by a historical perspective by Sir John Vane, Nobel Laureate, the book covers major topics ranging from the molecular basis of the ACE inhibitors to their application in several diseases of paramount importance such as hypertension, renal failure, diabetes and heart failure. Additional contributions address the multitude of peripheral factors which may modulate the efficacy and/or activity of the ACE inhibitors.>From a description of the genetic basis of ACE to epidemiological considerations on these potent molecules, this treatise should be of great benefit to clinical and non-clinical scientists, residents, the pharmacological industry and the decision-makers in health policy, providing the reader with a comprehensive review of the field of ACE inhibitors.

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