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Activities of Prenylphenol Derivatives from Fruitbodies of <i>Albatrellus</i> spp. on the Human and Rat Vanilloid Receptor 1 (VR1) and Characterisation of the Novel Natural Product, Confluentin
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Activities of Prenylphenol Derivatives from Fruitbodies of Albatrellus spp. on the Human and Rat Vanilloid Receptor 1 (VR1) and Characterisation of the Novel Natural Product, Confluentin

Author: Veronika Hellwig Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, PH-R EU ET Natural Products, Wuppertal, GermanyReilinde Nopper Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, GermanyFrank Mauler Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, GermanyJoachim Freitag Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, GermanyLiu Ji-Kai Affiliation: Kunming Institute of Botany, The Chinese Academy of Science, Kunming, P. R. ChinaAll authors
Edition/Format: Article Article : English
Publication:Archiv der Pharmazie, v336 n2 (April 2003): 119-126
Other Databases: WorldCat
Summary:
Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 15 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the μM range), rather than exhibiting agonistic activities.  Read more...
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Document Type: Article
All Authors / Contributors: Veronika Hellwig Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, PH-R EU ET Natural Products, Wuppertal, Germany; Reilinde Nopper Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, Germany; Frank Mauler Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, Germany; Joachim Freitag Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, CNS Research, Wuppertal, Germany; Liu Ji-Kai Affiliation: Kunming Institute of Botany, The Chinese Academy of Science, Kunming, P. R. China; Ding Zhi-Hui Affiliation: Kunming Institute of Botany, The Chinese Academy of Science, Kunming, P. R. China; Marc Stadler Affiliation: Bayer Health Care, Pharma Research Center Wuppertal, PH-R EU ET Natural Products, Wuppertal, Germany
ISSN:0365-6233
Language Note: English
Unique Identifier: 5154966356
Notes: Number of Figures: 5
Number of Tables: 2
Number of References: 21
Awards:

Abstract:

Several prenylphenols from basidiocarps of European and Chinese Albatrellus spp., namely grifolin (1), neogrifolin (2), confluentin (3), scutigeral (4), and albaconol (5) were investigated concerning their activities in test models for vanilloid receptor modulation. The isolation of these compounds from A. confluens and structure elucidation of the novel natural product confluentin (3) are described. The effects of scutigeral and neogrifolin on vanilloid receptors were studied by means of electrophysiological methodology on rat dorsal root ganglion neurons as well as on recombinant cell lines expressing the rat VR1 receptor. Concurrently, the effects of compounds 15 on a reporter cell line expressing the human vanilloid receptor VR1 were measured. In contrast to previous studies reported in the literature, the results of these investigations suggest that fungal prenylphenols act as weak antagonists (activity in the μM range), rather than exhibiting agonistic activities.

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