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Advancement in the pathophysiology of cerebral stroke

Author: Ranjana Patnaik; Amit Kumar Tripathi; Ashish Dwivedi
Publisher: Singapore : Springer, [2019]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it. The first section discusses the different ischemic cerebral stroke-induced inflammatory pathways and dysfunctionality of blood-brain barrier. The later sections of the book deals with the role of endoplasmic reticulum stress and mitophagy  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Patnaik, Ranjana.
Advancement in the Pathophysiology of Cerebral Stroke.
Singapore : Springer, ©2019
(OCoLC)1039673270
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ranjana Patnaik; Amit Kumar Tripathi; Ashish Dwivedi
ISBN: 9789811314537 9811314535 9789811314544 9811314543
OCLC Number: 1102469591
Description: 1 online resource (188 pages)
Contents: Intro; Contents; About the Editors; Chapter 1: Cerebral Stroke: An Introduction; 1.1 Introduction; 1.2 Types of Stroke; 1.2.1 Ischemic Stroke; 1.2.2 Hemorrhagic Stroke; 1.2.3 Transient Ischemic Attack; 1.3 Stroke Pathophysiology; 1.4 Current Treatment Option for Stroke Patients; 1.5 Neuroprotective Agents in Preclinical and Clinical Trials; 1.6 Stroke-Induced BBB Disruption; 1.7 Ischemic Stroke-Induced ER Stress; 1.8 The Emerging Role of mi-RNA in Stroke Pathophysiology; 1.9 Neuroprotective Potential of Low-Frequency Electromagnetic Field; 1.10 Stem Cell Therapies for Cerebral Stroke 1.11 ConclusionReferences; Chapter 2: Inflammation, Oxidative Stress, and Cerebral Stroke: Basic Principles; 2.1 Introduction; 2.2 Inflammation; 2.3 Inflammatory Role of Cytokines and Chemokines During Cerebral Stroke; 2.4 Oxidative Stress; 2.5 Treatment Strategy for Stroke; 2.5.1 Targeting Antioxidant Enzyme as a Therapeutic Strategy for Ischemic Stroke; 2.5.2 Regulation of Microglial Activation in Stroke; 2.5.3 Targeting the Cholinergic Anti-inflammatory Pathway; References; Chapter 3: Stroke Induced Blood-Brain Barrier Disruption; 3.1 Introduction; 3.2 BBB Anatomy 3.3 BBB Junctional Complexes3.3.1 Adherens Junctions (AJs); 3.3.2 Tight Junctions (TJs); 3.3.3 Gap Junctions; 3.3.3.1 Junctional Adhesion Molecule (JAM); 3.3.3.2 Occludin; 3.3.3.3 Claudins; 3.3.4 Membrane-Associated Guanylate Kinase (MAGUK)-Like Proteins; 3.3.5 Accessory Proteins; 3.4 Calcium Modulation of TJ and TJ Proteins; 3.5 Phosphorylation: A Novel Regulatory Mechanism of TJ Proteins; 3.6 Impairment of BBB Integrity in Neuropathological Disorder; 3.6.1 Alteration of BBB Integrity in Stroke Injury; 3.7 Evaluation of BBB Disruption in Rodent Ischemic Stroke 3.8 Quantitative Evaluation of BBB in Ischemic Stroke Using Dynamic Contrast-Enhanced (DCE) MRI3.9 Conclusion; References; Chapter 4: Ischemic Stroke-Induced Endoplasmic Reticulum Stress; 4.1 Introduction; 4.2 ER Stress, UPR, and Ischemia; 4.2.1 Components of UPR in Ischemia; 4.2.1.1 GRP78; 4.2.1.2 PERK; 4.2.1.3 ATF6; 4.2.1.4 IRE1; 4.3 Chronic ER Stress, UPR, and Pro-apoptotic Signaling in IR Injury; 4.3.1 CHOP; 4.3.2 Caspase 12; 4.3.3 JNK; 4.4 ER Stress and Autophagy in IR Injury; 4.5 ER Stress and miRNAs in IR Injury; 4.6 Conclusion; References Chapter 5: The Role of Autophagy in Ischaemic Stroke: Friend or Foe?5.1 Introduction; 5.2 Pathophysiology of Ischaemic Stroke; 5.3 Various Animal Models to Study IS; 5.3.1 Intra-arterial Suture Middle Cerebral Arterial Occlusion Model; 5.3.2 Craniotomy Model; 5.3.3 Photothrombosis Model; 5.3.4 Endothelin-I Model; 5.3.5 Clot Embolic Model of Stroke; 5.4 Autophagy and Its Machinery; 5.5 Autophagy and Its Role in Cerebral Ischaemia; 5.5.1 Autophagy Activation in Ischaemic Stroke Protects Neurons; 5.5.2 Autophagy Is Also Responsible for Neuronal Death After Ischaemic Stroke
Responsibility: Ranjana Patnail, AMit Kumar Tripathi, Ashish Dwivedi, editors.

Abstract:

This book provides detailed and comprehensive mechanistic insights of the various risk factors that lead to the ischemic stroke and the novel therapeutic interventions against it.  Read more...

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