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Advances in membrane proteins : building, signaling and malfunction

Author: Yu Cao
Publisher: Singapore : Springer, 2019.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
This book reviews recent advances regarding the biochemical and biophysical properties of membrane proteins and their applications in biomedicine. Divided into two thematic parts, this second volume addresses proteins' formation, signaling and malfunctions. It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Cao, Yu.
Advances in Membrane Proteins : Building, Signaling and Malfunction.
Singapore : Springer, ©2019
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yu Cao
ISBN: 9789811390777 9811390770 9789811390784 9811390789 9789811390791 9811390797
OCLC Number: 1122450656
Notes: Substrate Recognition
Description: 1 online resource (132 pages)
Contents: Intro; Acknowledgement; Contents; Lipid Homeostasis on Cell Membrane; Phospholipid Biosynthesis (Kennedy Pathway); Biosynthesis of Phosphatidic Acid (PA); Biosynthesis of PIs; Biosynthesis of PS; Biosynthesis of PE; Biosynthesis of PC; Phospholipid Remodeling (Non-Kennedy Pathway); LPCAT1; LPCAT2; LPCAT3; LPCAT4; LPEAT1; LPEAT2; Phospholipids and Membrane; PA/LPA and Membrane; PIs and Membrane; PS and Membrane; PE and Membrane; PCs and Membrane; SM; SPT and Its Subunits; SMS Family; SM as a Critical Component of Lipid Rafts; SM-Enriched Cell Membrane Lipid Rafts Early Structural Work on RhodopsinGPCR Structural Biology After 2007; GPCR Dynamics; References; Membrane Proteins as Targets for Biological Drugs; Introduction; Targeting Membrane Expressed Receptors; Antibody Drug Conjugates; PK and In Vivo Activity of Biologics; Advances in Immuno-oncology; Concluding Remarks; References; Cell Adhesion Molecules; Brief Introduction; IgSF; Structure; Function; Wiring of Brain Synapses; Integrins; Activation; Function; Selectins; Functions; Cadherins; Functions; References; The Biosynthesis and Folding of Oily Peptide Chains; Introduction; ER Targeting Translocation and ER TargetingFunctions of the Signal Peptides and Anchor Sequences; Protein Folding in the ER; Chaperone Assisted Folding; The BiP Chaperone Complex; The Lectin-Chaperones Complex; Co-translational Folding; Co-translational Event Involving the Ribosome; Translocon as a Hub for Co-translational Folding; Protein Modification in the ER; Glycosylation in the ER; Disulfide Bond Formation; Peptidyl-Prolyl cis-trans Isomerization; Protein Assembly in the ER; Selective Oligomerization; Hetero-oligomerization of Membrane Proteins; Homo-oligomerization; Proteins Exit from the ER Golgi ProcessingDefective Biosynthesis of Membrane Proteins and Human Diseases; Human Diseases Caused by Defects in Protein Biosynthesis; Rescue Defective Function by Pharmacological Chaperones; References; Mechanism of Quality Control of Nascent Membrane Proteins; Maturation of Membrane Proteins Within ER Membrane; Membrane Protein Folding Is Coupled with Biosynthesis, Translocation, Modification, and Topogenesis; Overview of Protein Folding, Protein Degradation, and Ubiquitin-Proteasome System (UPS); Protein Degradation from ER: ER-Associated Degradation (ERAD) Pathway
Responsibility: Yu Cao, editor.

Abstract:

It covers a number of important membrane proteins including receptors, cell adhesion molecules, single-transmembrane proteins and viral membrane proteins, and discusses their structures, functions,  Read more...

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