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The Aging Process Deconstructed: Glucose Production, Cancer Resistance and Longevity

Author: Gillings School of Global Public Health, Department of Nutrition; Combs, Terry P.; Alderman, Jennifer M.
Publisher: 2009-05
Dissertation: Thesis / Dissertation ETD
Edition/Format:   Thesis/dissertation : Thesis/dissertation : eBook : English
Summary:
The aging process affects all mammals and is typically seen with a gradual decline in overall system functionality. This can affect organ and immune function, resulting in increased susceptibility to diseases such as cancer. There are many theories as to specific mechanisms of longevity; we investigate the neuroendocrine regulation of glucose utilization as a potential mediator. Animal models are valuable tools in  Read more...
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Details

Genre/Form: Masters Thesis
Material Type: Thesis/dissertation, Internet resource
Document Type: Internet Resource
All Authors / Contributors: Gillings School of Global Public Health, Department of Nutrition; Combs, Terry P.; Alderman, Jennifer M.
OCLC Number: 1105759853
Language Note: English

Abstract:

The aging process affects all mammals and is typically seen with a gradual decline in overall system functionality. This can affect organ and immune function, resulting in increased susceptibility to diseases such as cancer. There are many theories as to specific mechanisms of longevity; we investigate the neuroendocrine regulation of glucose utilization as a potential mediator. Animal models are valuable tools in our efforts to perform gerontological research. Increased lifespan in rodents and mice has been observed through calorie restriction and single mutations, such as Pit-/- and Proph1-/-. Our results in Snell dwarf mice suggest that the pituitary gland and adipose tissue are part of a neuroendocrine loop that lowers the risk of cancer during aging by reducing the availability of glucose.

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