skip to content
Covid-19 virus
COVID-19 Resources

Reliable information about the coronavirus (COVID-19) is available from the World Health Organization (current situation, international travel). Numerous and frequently-updated resource results are available from this WorldCat.org search. OCLC’s WebJunction has pulled together information and resources to assist library staff as they consider how to handle coronavirus issues in their communities.

Image provided by: CDC/ Alissa Eckert, MS; Dan Higgins, MAM
Allosteric Drug Antagonism-7 Preview this item
ClosePreview this item
Checking...

Allosteric Drug Antagonism-7

Edition/Format: Chapter Chapter : English
Summary:
This chapter discusses various aspects of allosteric drug antagonism. A major molecular mechanism of receptor antagonism involves the binding of the antagonist to its own site on the receptor separate from the binding site of the endogenous agonist. Allosteric effects are defined by the interaction of an allosteric modulator at an allosteric binding site on the protein to affect the conformation at the probe site of  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Find a copy online

Links to this item

Find a copy in the library

We were unable to get information about libraries that hold this item.

Details

ISBN: 978-0-12-370599-0
Publication:A Pharmacology Primer; 127-146; Elsevier Inc.
Language Note: English
Unique Identifier: 4934397078
Awards:

Abstract:

This chapter discusses various aspects of allosteric drug antagonism. A major molecular mechanism of receptor antagonism involves the binding of the antagonist to its own site on the receptor separate from the binding site of the endogenous agonist. Allosteric effects are defined by the interaction of an allosteric modulator at an allosteric binding site on the protein to affect the conformation at the probe site of the protein. Allosteric modulators affect the interaction of the receptor and probe molecules by binding to separate sites on the receptor. These effects are transmitted through changes in the receptor protein. Allosteric modulators possess properties different from orthosteric ligands. It is found that allosteric effects are saturable and probe dependent. The dextral displacement reaches a maximal value leading to a curvilinear Schild regression. Allosteric modulators that block receptor function produce insurmountable antagonism. It is observed that modulators that block function also can alter affinity.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.
Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


\n\n

Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/4934397078<\/a>> # Allosteric Drug Antagonism-7<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a>, bgn:Chapter<\/a> ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"4934397078<\/span>\" ;\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"949 $l book<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"This chapter discusses various aspects of allosteric drug antagonism. A major molecular mechanism of receptor antagonism involves the binding of the antagonist to its own site on the receptor separate from the binding site of the endogenous agonist. Allosteric effects are defined by the interaction of an allosteric modulator at an allosteric binding site on the protein to affect the conformation at the probe site of the protein. Allosteric modulators affect the interaction of the receptor and probe molecules by binding to separate sites on the receptor. These effects are transmitted through changes in the receptor protein. Allosteric modulators possess properties different from orthosteric ligands. It is found that allosteric effects are saturable and probe dependent. The dextral displacement reaches a maximal value leading to a curvilinear Schild regression. Allosteric modulators that block receptor function produce insurmountable antagonism. It is observed that modulators that block function also can alter affinity.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/1189826453<\/a>> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Allosteric Drug Antagonism-7<\/span>\" ;\u00A0\u00A0\u00A0\nschema:pageStart<\/a> \"127<\/span>\" ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"4934397078<\/span>\" ;\u00A0\u00A0\u00A0\nschema:sameAs<\/a> <http:\/\/dx.doi.org\/10.1016\/B978-012370599-0\/50008-3<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/4934397078<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Related Entities<\/h3>\n