skip to content
Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
ClosePreview this item
Checking...

Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.

Author: TG Schurr Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA.SW BallingerYY GanJA HodgeDA MerriwetherAll authors
Edition/Format: Article Article : English
Publication:American journal of human genetics, 1990 Mar; 46(3): 613-23
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Summary:
The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

More like this

 

&AllPage.SpinnerRetrieving;

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Document Type: Article
All Authors / Contributors: TG Schurr Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA.; SW Ballinger; YY Gan; JA Hodge; DA Merriwether; DN Lawrence; WC Knowler; KM Weiss; DC Wallace
ISSN:0002-9297
Language Note: English
Unique Identifier: 120356210
Awards:

Abstract:

The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

User lists with this item (1)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/120356210> # Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
    a schema:Article, schema:CreativeWork ;
    library:oclcnum "120356210" ;
    rdfs:comment "949 $l Research Support, U.S. Gov't, Non-P.H.S." ;
    rdfs:comment "949 $l Journal Article" ;
    rdfs:comment "949 $l Research Support, Non-U.S. Gov't" ;
    schema:about <http://experiment.worldcat.org/entity/work/data/100299993#Topic/mutation> ; # Mutation
    schema:about <http://experiment.worldcat.org/entity/work/data/100299993#Place/asia> ; # Asia
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/gan_yy> ; # Gan YY
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/knowler_wc> ; # Knowler WC
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/ballinger_sw> ; # Ballinger SW
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/wallace_dc> ; # Wallace DC
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/lawrence_dn> ; # Lawrence DN
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/hodge_ja> ; # Hodge JA
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/merriwether_da> ; # Merriwether DA
    schema:contributor <http://experiment.worldcat.org/entity/work/data/100299993#Person/weiss_km> ; # Weiss KM
    schema:creator <http://experiment.worldcat.org/entity/work/data/100299993#Person/schurr_tg> ; # Schurr TG
    schema:description "The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations." ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/100299993> ;
    schema:isPartOf <http://worldcat.org/issn/0002-9297#46_3> ;
    schema:name "Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages." ;
    schema:pageStart "613" ;
    schema:productID "120356210" ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/120356210> ;
    .


Related Entities

<http://worldcat.org/issn/0002-9297>
    a schema:Periodical ;
    rdfs:label "American journal of human genetics" ;
    schema:issn "0002-9297" ;
    .

<http://www.worldcat.org/title/-/oclc/120356210>
    a genont:InformationResource, genont:ContentTypeGenericResource ;
    schema:about <http://www.worldcat.org/oclc/120356210> ; # Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
    schema:dateModified "2016-06-14" ;
    void:inDataset <http://purl.oclc.org/dataset/medline> ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.