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Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.
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Amerindian mitochondrial DNAs have rare Asian mutations at high frequencies, suggesting they derived from four primary maternal lineages.

Auteur : TG Schurr Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA.SW BallingerYY GanJA HodgeDA MerriwetherTous les auteurs
Édition/format: Article Article : Anglais
Source:American journal of human genetics, 1990 Mar; 46(3): 613-23
Résumé:
The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the  Lire la suite...
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Détails

Type de document: Article
Tous les auteurs / collaborateurs: TG Schurr Affiliation: Department of Biochemistry, Emory University School of Medicine, Atlanta, GA.; SW Ballinger; YY Gan; JA Hodge; DA Merriwether; DN Lawrence; WC Knowler; KM Weiss; DC Wallace
ISSN:0002-9297
Note sur la langue: English
Identificateur Unique : 120356210
Récompenses:

Résumé:

The mitochondrial DNA (mtDNA) sequence variation of the South American Ticuna, the Central American Maya, and the North American Pima was analyzed by restriction-endonuclease digestion and oligonucleotide hybridization. The analysis revealed that Amerindian populations have high frequencies of mtDNAs containing the rare Asian RFLP HincII morph 6, a rare HaeIII site gain, and a unique AluI site gain. In addition, the Asian-specific deletion between the cytochrome c oxidase subunit II (COII) and tRNA(Lys) genes was also prevalent in both the Pima and the Maya. These data suggest that Amerindian mtDNAs derived from at least four primary maternal lineages, that new tribal-specific variants accumulated as these mtDNAs became distributed throughout the Americas, and that some genetic variation may have been lost when the progenitors of the Ticuna separated from the North and Central American populations.

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Primary Entity

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