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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Document, Thesis/dissertation |
Document Type: | Computer File |
All Authors / Contributors: |
Stéphane Vignot; Jean-Charles Soria; Martin Schlumberger; Frédérique Penault-Llorca; Julien Mazières; Fabrice André; Université Paris-Sud (1970-2019).; Ecole doctorale Cancérologie : Biologie, Médecine, Santé (2000-2015 / Le Kremlin-Bicêtre, Val-de-Marne).; Prédicteurs moléculaires et nouvelles cibles en oncologie (Villejuif, Val-de-Marne / 2010-....). |
OCLC Number: | 863126253 |
Notes: | Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Stéphane Vignot ; sous la direction de Jean-Charles Soria. |
Abstract:
The question of spatial and temporal variability of biomarkers in solid tumors is a key issue in an era where personalized therapy is strongly advocated by clinicians, researchers and patients. The purpose of the work is to compare molecular profiles of primary tumor and matched metastasis in order to precise tumor heterogeneity during metastatic progression and to investigate pathways potentially involved in the metastatic process.Frozen samples from two cohorts of patients were considered: non-small cell lung cancer (15 patients) and colorectal cancer (13 patients, 11 patients with healthy control tissues). These samples were analyzed by high-throughput sequencing and gene expression. Highly conserved genomic profiles were observed in the first metastatic progression for known recurrent genes in non-small cell lung cancer and colorectal cancer. If gene expression studies do not highlight specific profile of metastasis, they provide useful data on the conservation of some important oncogenic pathways; identify genes of interest in the study of metastatic progression and highlight the putative impact of the effect of healthy tissue for expression analysis.
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