Ancestral sequence reconstruction (eBook, 2007) []
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Ancestral sequence reconstruction

Author: David A Liberles
Publisher: Oxford ; New York : Oxford University Press, 2007.
Edition/Format:   eBook : Document : EnglishView all editions and formats

Ancestral sequence reconstruction is an interdisciplinary field of growing importance for understanding the evolution of molecular function. The technique is poised to become a mainstream component  Read more...


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Genre/Form: Electronic books
Additional Physical Format: Print version:
Ancestral sequence reconstruction.
Oxford ; New York : Oxford University Press, 2007
(DLC) 2007299128
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: David A Liberles
ISBN: 9781435623712 1435623711
OCLC Number: 191672003
Description: 1 online resource (xiii, 252 pages) : illustrations
Contents: 1. The Early Days of Paleogenomics, Connecting Molecules to the Planet; 2. Ancestral Sequence Reconstruction as a Tool to Understand Natural History and Guide Synthetic Biology: Realizing and Extending the Vision of Zuckerkandl and Pauling; 3. Linking Sequence to Function in Drug Design with Ancestral Sequence Reconstruction; 4. Probabilistic Models and Their Impact on the Accuracy of Reconstructed Ancestral Sequences; 5. Probabilistic Ancestral Sequences Based on the Markovian Model of Evolution- Algorithms and Applications; 6. Estimating the History of Mutations on a Phylogeny; 7. Coarse Projections of the Protein-Mutational Fitness Landscape; 8. Dealing with Uncertainty in Ancestral Sequence Reconstruction: Sampling from the Posterior Distribution; 9. Evolutionary Properties of Sequences and Ancestral State Reconstruction; 10. Reconstructing the Ancestral Eukaryote- Lessons from the Past; 11. Using Ancestral Sequence Inference to Determine the Trend of Functional Divergence After Gene Duplication; 12. Reconstruction of Ancestral Proteomes; 13. Computational Reconstruction of Ancestral Genomic Regions from Evolutionarily Conserved Gene Clusters; 14. Experimental Resurrection of Ancient Biomolecules: Gene Synthesis, Heterologous Protein Expression, and Functional Assays; 15. Dealing with Model Uncertainty in Reconstructing Ancestral Proteins in the Laboratory: Examples from Ancestral Visual Pigments and GFP-like Proteins; 16. Unraveling the Evolution of Complexity by Resurrecting Ancient Genes; 17. A Thermophilic Last Universal Ancestor Inferred from its Estimated Amino Acid Composition; 18. The Resurrection of Ribonucleases from Mammals. From Ecology to Medicine; 19. Evolution of Specificity and Diversity.
Responsibility: edited by David A. Liberles.


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This combination of theory and application is unusual and broadens the appeal of the book for researchers or for teachers of advanced seminars...This gives the book a light and readable quality * Read more...

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