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Animal models in cancer drug discovery

Author: Asfar S Azmi; Ramzi M Mohammad
Publisher: London, United Kingdom ; Cambridge, MA : Academic Press, [2019]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
(OCoLC)1057305250
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Asfar S Azmi; Ramzi M Mohammad
ISBN: 9780128147054 0128147059
OCLC Number: 1097960825
Description: 1 online resource (xx, 450 pages)
Contents: Chapter 1 --
Role of animal research in human malignancies --
Chapter 2 --
Preclinical models in ovarian cancer --
Chapter 3 --
Animal models of cancer-associated cachexia --
Chapter 4 --
Imaging tools to enhance animal tumor models for cancer research and drug discovery --
Chapter 5 --
Protocols in genetic mice models of pancreatic cancer --
Chapter 6 --
Chemo-prevention and interception of obesity-promoted pancreatic ductal adenocarcinoma --
Chapter 7 --
Animal models of primary brain tumors --
Chapter 8 --
Metastatic brain tumor models and drug brain penetration analysis --
Chapter 9 --
A guide to tumor assessment methodologies in cancer drug discovery --
Chapter 10 --
Mouse models of pancreatic cancer: An ever-emerging arm of cancer drug discovery --
Chapter 11 --
Mouse models of gastrointestinal cancers in drug development and research --
Chapter 12 --
Preclinical animal tumor models to study prevention of colon cancer recurrence by curcumin --
Chapter 13 --
Role of 3D tissue engineering models for human cancer and drug development --
Chapter 14 --
Drug development using pancreatic and lung organoid models --
Chapter 15 --
Leveraging dogs with spontaneous cancer to advance drug development --
Chapter 16 --
Cancer imaging in preclinical models --
Chapter 17 --
Animal (mouse) models of melanoma --
Chapter 18 --
Animal mouse models of acute myeloid leukemia
Responsibility: edited by Asfar Azmi, Ramzi M. Mohammad.

Abstract:

Animal Models in Cancer Drug Discovery brings forward the most cutting-edge developments in tumor model systems for translational cancer research. The reader can find under this one volume virtually all types of existing and emerging tumor models in use by the research community. This book provides a deeper insight on how these newer models could de-risk modern drug discovery. Areas covered include up to date information on latest organoid derived models and newer genetic models. Additionally, the book discusses humanized animal tumor models for cancer immunotherapy and how they leverage personalized therapies. The chapter on larger animal, canine models and their use in and their use in pre-investigational new drug (pre-IND) development makes the volume unique. Unlike before, the incorporation of several simplified protocols, breeding methodologies, handling and assessment procedures to study drug intervention makes this book a must read. Animal Models in Cancer Drug Discovery is a valuable resource for basic and translational cancer researchers, drug discovery researchers, contract research organizations, and knowledge seekers at all levels in the biomedical field.

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