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Animal Models of Dementia

Author: Peter Paul De Deyn; Debby Van Dam
Publisher: Totowa, NJ Humana Press, 2011.
Series: Neuromethods, 48.
Edition/Format:   eBook : Document : English : 1View all editions and formats
Summary:
With an ever-increasing elderly population and the resultant rising levels of dementia-related disorders, preclinical research based on animal models is pivotal to our knowledge of underlying molecular mechanisms and drug discovery aiming at the development of therapeutic strategies alleviating or preventing the neurological devastation. In Animal Models of Dementia, expert researchers provide contributions that  Read more...
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Genre/Form: Electronic books
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Peter Paul De Deyn; Debby Van Dam
ISBN: 1607618982 9781607618980 1607618974 9781607618973
OCLC Number: 1058368364
Language Note: English.
Description: 1 online resource (XVI, 732 pages)
Contents: General introduction to animal models of human conditions / Peter Paul De Deyn and Debby Van Dam --
Animal models of dementia : ethical considerations / I. Anna S. Olsson and Peter Sandøe --
The role of rodent models in the drug discovery pipeline for dementia / Debby Van Dam and Peter Paul De Deyn --
Species, strain, and gender issues in the development and validation of animal models of dementia / Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn --
Transgenic and gene targeted models of dementia / Ronald A. Conlon --
Transgenic animals and intellectual property concerns / Susan L. Stoddard and James A. Rogers III --
Pathological validation of animal models of dementia / Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh --
Behavioral validation in animal models of dementia / Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn --
Pharmacological validation in animal models of dementia / Hugo Geerts --
Validation of animal models of dementia : neurochemical aspects / Giancarlo Pepeu and Maria Cristina Rosi --
Validation of dementia models employing neuroimaging techniques / Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden --
Drosophila melanogaster as a model organism for dementia / Maria E. Giannakou and Damian C. Crowther --
Caenorhabditis elegans as a model organism for dementia / Tjakko J. Van Ham and Ellen A.A. Nollen --
Zebrafish (Danio rerio) as a model organism for dementia / Rob Willemsen [and others] --
Spontaneous vertebrate models of Alzheimer dementia : selectively bred strains (SAM strains) / Renã A. Sowell and D. Allan Butterfield --
Lesion-induced vertebrate models of Alzheimer dementia / Adolfo Toledano and Maria Isabel Álvarez --
A[Beta] infusion and related models of Alzheimer dementia / Patricia A. Lawlor and Deborah Young --
APP-based transgenic models : the PDAPP model / Jacob M. Basak and David M. Holtzman --
APP-based transgenic models : the Tg2576 model / Robert M.J. Deacon --
APP-based transgenic models : the APP23 model / Debby Van Dam and Peter Paul De Deyn --
Presenilin-based transgenic models of Alzheimer's dementia / Yuji Yoshiike and Akihiko Takashima --
APOE-based models of "pre-dementia" / Patrick M. Sullivan --
TAU models / Nicolas Sergeant and Luc Buée --
The 3xTg-AD mouse model : reproducing and modulating plaque and tangle pathology / Michael Sy, Masashi Kitazawa, and Frank LaFerla --
Cognitive dysfunction in genetic mouse models of parkinsonism / Sheila M. Fleming, J. David Jentsch, and Marie-Françoise Chesselet --
Mouse models of metachromatic leukodystrophy and adrenoleukodystrophy / Patrick Aubourg, Caroline Sevin, and Nathatie Cartier --
Animal models of amyotrophic lateral sclerosis / Ludo Van Den Bosch --
Animal models of frontotemporal dementia / Hana N. Dawson and Daniel T. Laskowitz --
CADASIL : molecular mechanisms and animal models / Karl J. Fryxell --
Spontaneously hypertensive rat (SHR) : an animal model of vascular brain disorder / Francesco Amenta and Daniele Tomassoni --
Animal models of normal pressure hydrocephalus / Petra M. Klinge --
Animal models of traumatically-induced dementia / Jennifer E. Slemmer, Mohammad Z. Hossain, and John T. Weber --
Animal models of alcohol-induced dementia / Angela Maria Ribeiro and Silvia R. Castanheira Pereira --
Animal models of metallic dementia / Luigi F. Rodella.
Series Title: Neuromethods, 48.
Other Titles: Neuromethods, Volume 48
Responsibility: edited by Peter Paul De Deyn, Debby Van Dam.

Abstract:

Comprehensive and efficient, this book will significantly aid both experienced animal researchers as well as investigators on the verge of beginning animal model-based dementia research. It includes  Read more...

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From the book reviews:"A complete guide to lesion induced, genetic knockout, and phylogenetic approaches to dementias is catalogued. ... I recommend this book for animal researcher for sure, and Read more...

 
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# Analytical, Diagnostic and Therapeutic Techniques and Equipment<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/dementia_research_treatment<\/a>> ; # Dementia--Research--Treatment<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/central_nervous_system_diseases<\/a>> ; # Central Nervous System Diseases<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/health_&_biological_sciences<\/a>> ; # Health & Biological Sciences<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/psychiatry<\/a>> ; # Psychiatry<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/brain_diseases<\/a>> ; # Brain Diseases<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/neurocognitive_disorders<\/a>> ; 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# Dementia<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/dewey.info\/class\/636.0885\/<\/a>> ;\u00A0\u00A0\u00A0\nschema:alternateName<\/a> \"Neuromethods, Volume 48<\/span>\" ;\u00A0\u00A0\u00A0\nschema:bookEdition<\/a> \"1.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:bookFormat<\/a> schema:EBook<\/a> ;\u00A0\u00A0\u00A0\nschema:creator<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Person\/de_deyn_peter_paul<\/a>> ; # Peter Paul De Deyn<\/span>\n\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2011<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"General introduction to animal models of human conditions \/ Peter Paul De Deyn and Debby Van Dam -- Animal models of dementia : ethical considerations \/ I. Anna S. Olsson and Peter Sand\u00F8e -- The role of rodent models in the drug discovery pipeline for dementia \/ Debby Van Dam and Peter Paul De Deyn -- Species, strain, and gender issues in the development and validation of animal models of dementia \/ Annemie Van Dijck, Debby Van Dam, and Peter Paul De Deyn -- Transgenic and gene targeted models of dementia \/ Ronald A. Conlon -- Transgenic animals and intellectual property concerns \/ Susan L. Stoddard and James A. Rogers III -- Pathological validation of animal models of dementia \/ Daniel Pirici, Christine Van Broeckhoven, and Samir Kumar-Singh -- Behavioral validation in animal models of dementia \/ Debby Van Dam, Annemie Van Dijck, and Peter Paul De Deyn -- Pharmacological validation in animal models of dementia \/ Hugo Geerts -- Validation of animal models of dementia : neurochemical aspects \/ Giancarlo Pepeu and Maria Cristina Rosi -- Validation of dementia models employing neuroimaging techniques \/ Greet Vanhoutte, Adriaan Campo, and Annemie Van der Linden -- Drosophila melanogaster as a model organism for dementia \/ Maria E. Giannakou and Damian C. Crowther -- Caenorhabditis elegans as a model organism for dementia \/ Tjakko J. Van Ham and Ellen A.A. Nollen -- Zebrafish (Danio rerio) as a model organism for dementia \/ Rob Willemsen [and others] -- Spontaneous vertebrate models of Alzheimer dementia : selectively bred strains (SAM strains) \/ Ren\u00E3 A. Sowell and D. Allan Butterfield -- Lesion-induced vertebrate models of Alzheimer dementia \/ Adolfo Toledano and Maria Isabel \u00C1lvarez -- A[Beta] infusion and related models of Alzheimer dementia \/ Patricia A. Lawlor and Deborah Young -- APP-based transgenic models : the PDAPP model \/ Jacob M. Basak and David M. Holtzman -- APP-based transgenic models : the Tg2576 model \/ Robert M.J. Deacon -- APP-based transgenic models : the APP23 model \/ Debby Van Dam and Peter Paul De Deyn -- Presenilin-based transgenic models of Alzheimer\'s dementia \/ Yuji Yoshiike and Akihiko Takashima -- APOE-based models of \"pre-dementia\" \/ Patrick M. Sullivan -- TAU models \/ Nicolas Sergeant and Luc Bu\u00E9e -- The 3xTg-AD mouse model : reproducing and modulating plaque and tangle pathology \/ Michael Sy, Masashi Kitazawa, and Frank LaFerla -- Cognitive dysfunction in genetic mouse models of parkinsonism \/ Sheila M. Fleming, J. David Jentsch, and Marie-Fran\u00E7oise Chesselet -- Mouse models of metachromatic leukodystrophy and adrenoleukodystrophy \/ Patrick Aubourg, Caroline Sevin, and Nathatie Cartier -- Animal models of amyotrophic lateral sclerosis \/ Ludo Van Den Bosch -- Animal models of frontotemporal dementia \/ Hana N. Dawson and Daniel T. Laskowitz -- CADASIL : molecular mechanisms and animal models \/ Karl J. Fryxell -- Spontaneously hypertensive rat (SHR) : an animal model of vascular brain disorder \/ Francesco Amenta and Daniele Tomassoni -- Animal models of normal pressure hydrocephalus \/ Petra M. Klinge -- Animal models of traumatically-induced dementia \/ Jennifer E. Slemmer, Mohammad Z. Hossain, and John T. Weber -- Animal models of alcohol-induced dementia \/ Angela Maria Ribeiro and Silvia R. Castanheira Pereira -- Animal models of metallic dementia \/ Luigi F. 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Beginning with general aspects of animal modeling, related ethical issues, and essential methodological considerations, the highly detailed volume then continues with various levels of model validation, including pathological, behavioral, neurochemical, pharmacological, and imaging aspects, followed by sections focused on specific disorders, such as Alzheimer\'s disease, Parkinson\'s disease, metachromatic leukodystrophy and adrenoleukodystrophy, amyotrophic lateral sclerosis, frontotemporal dementia as well as vascular dementia and more. As a volume in the renowned Neuromethods series, this book offers a detailed, yet accessible, overview of currently available animal models in the field of dementia research, and touches, as well, upon more general areas linked to the development and use of animal models. 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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/dementia<\/a>> # Dementia<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Dementia<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
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<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/disease<\/a>> # Disease<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Disease<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/disease_models_animal<\/a>> # Disease Models, Animal<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Disease Models, Animal<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/drug_therapy<\/a>> # Drug Therapy<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Drug Therapy<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/health_&_biological_sciences<\/a>> # Health & Biological Sciences<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Health & Biological Sciences<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/investigative_techniques<\/a>> # Investigative Techniques<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Investigative Techniques<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/mental_disorders<\/a>> # Mental Disorders<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Mental Disorders<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/models_animal<\/a>> # Models, Animal<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Models, Animal<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/models_biological<\/a>> # Models, Biological<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Models, Biological<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/models_theoretical<\/a>> # Models, Theoretical<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Models, Theoretical<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/nervous_system_diseases<\/a>> # Nervous System Diseases<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Nervous System Diseases<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/neurocognitive_disorders<\/a>> # Neurocognitive Disorders<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Neurocognitive Disorders<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/psychiatric_disorders_individual<\/a>> # Psychiatric Disorders, Individual<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Psychiatric Disorders, Individual<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/psychiatry<\/a>> # Psychiatry<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Psychiatry<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/psychiatry_and_psychology<\/a>> # Psychiatry and Psychology<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Psychiatry and Psychology<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/895826706#Topic\/therapeutics<\/a>> # Therapeutics<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Therapeutics<\/span>\"@en<\/a> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/nju<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"nju<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/entity\/work\/data\/895826706#CreativeWork\/<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a> ;\u00A0\u00A0\u00A0\nschema:isSimilarTo<\/a> <http:\/\/www.worldcat.org\/oclc\/1058368364<\/a>> ; # Animal Models of Dementia<\/span>\n\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/isbn\/9781607618973<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"1607618974<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"9781607618973<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/isbn\/9781607618980<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:ProductModel<\/a> ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"1607618982<\/span>\" ;\u00A0\u00A0\u00A0\nschema:isbn<\/a> \"9781607618980<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/worldcat.org\/issn\/0893-2336<\/a>> # Neuromethods ;<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nbgn:PublicationSeries<\/a> ;\u00A0\u00A0\u00A0\nschema:hasPart<\/a> <http:\/\/www.worldcat.org\/oclc\/1058368364<\/a>> ; # Animal Models of Dementia<\/span>\n\u00A0\u00A0\u00A0\nschema:issn<\/a> \"0893-2336<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Neuromethods ;<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Neuromethods,<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n