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Anticonvulsants.

Author: Julius Vida
Publisher: Saint Louis : Elsevier Science, 2014.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Vida, Julius.
Anticonvulsants.
Saint Louis : Elsevier Science, ©2014
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Julius Vida
ISBN: 9780323143950 0323143954
OCLC Number: 1044715534
Description: 1 online resource (653 pages)
Contents: Front Cover; Anticonvulsants; Copyright Page; Table of Contents; Dedication; LIST OF CONTRIBUTORS; PREFACE; CHAPTER 1. ADVANCES IN ANTICONVULSANT DRUG DEVELOPMENT; REFERENCES; CHAPTER 2. NEUROPHARMACOLOGY AND TREATMENT OF EPILEPSY; I. INTRODUCTION; II. CLASSIFICATION OF SEIZURES; III. NEUROCHEMISTRY; IV. NEUROPHYSIOLOGY; V. MECHANISM OF ANTICONVULSANT DRUG ACTION; VI. THERAPEUTIC USE OF ANTICONVULSANT DRUGS; REFERENCES; CHAPTER 3. EXPERIMENTAL EVALUATION OF ANTICONVULSANTS; I. INTRODUCTION; II. METHODS; III. HYDANTOINS; IV. BARBITURATES AND RELATED COMPOUNDS; V. OXAZOLIDINEDIONES. VI. SUCCINIMIDESVII BENZODIAZEPINES; VIII. MISCELLANEOUS ANWCONVULSANTS; REFERENCES; CHAPTER 4. PHYSIOLOGICAL DISPOSITION OF ANTICONVULSANTS; I. INTRODUCTION; II. DIPHENYLHYDANTOIN AND OTHER HYDANTOINS; III. THE BARBITURATES; IV. PRIMIDONE; V. THE SUCCINIMIDES; VI. THE OXAZOLIDINEDIONES; VII. ACETYLUREAS; VIII. CARBAMAZEPINE; IX. THE BENZODIAZEPINES; X. ACETAZOLAMIDE; XI SULTHIAME; REFERENCES; CHAPTER 5. CYCLIC UREIDES; I. THE CYCLIC UREIDE STRUCTURE; II. BARBITURATES; III. ETEROBARB; IV. PRIMIDONE; V. HYDANTOINS; VI. DOXENITOINE; VII. OXAZOLIDINEDIONES; VIII. SUCCINIMIDES. IX. ADDENDUM: TABLES (1-62)CHAPTER 6. BENZOPYRANS; I. INTRODUCTION; II. CHEMISTRY; III. ANTICONVULSANT PROPERTIES; IV. DISCUSSION; ACKNOWLEDGMENTS; REFERENCES; CHAPTER 7. OTHER HETEROCYCLIC DRUGS; ABBREVIATIONS USED IN THE TABLES; I. SMALL-RING COMPOUNDS; II. FIVE-MEMBERED RINGS; III. SIX-MEMBERED RINGS; IV. SEVEN-MEMBERED AND LARGER RINGS (EXCEPT FOR DIAZEPINES); V. DIAZEPINES AND RELATED COMPOUNDS; REFERENCES; CHAPTER 8. NONCYCLIC ANTICONVULSANTS; I. GENERAL; II. UREA DERIVATIVES; III. CARBAMATES; IV. CARBOXYLIC ACIDS AND AMIDES; V. SULFONAMIDES; VI. HYDRAZONES. VII STRUCTURE-ACTIVITY RELATIONSHIPSREFERENCES; SUBJECT INDEX.

Abstract:

Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic dr.

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