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Application of a mathematical model and Differential Evolution algorithm approach to optimization of bacteriocin production by Lactococcus lactis C7
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Application of a mathematical model and Differential Evolution algorithm approach to optimization of bacteriocin production by Lactococcus lactis C7

Author: Sompop MoonchaiWeeranuch MadlhooKanidtha JariyachavalitHiroshi ShimizuSuteaki ShioyaAll authors
Publisher: Springer
Edition/Format: Article Article : English
Publication:Bioprocess and Biosystems Engineering, 28, no. 1 (2005): 15-26
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Document Type: Article
All Authors / Contributors: Sompop Moonchai; Weeranuch Madlhoo; Kanidtha Jariyachavalit; Hiroshi Shimizu; Suteaki Shioya; Somchai Chauvatcharin
ISSN:1615-7591
Language Note: English
Unique Identifier: 440128033
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Primary Entity

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    schema:about <http://experiment.worldcat.org/entity/work/data/83064125#Thing/bacteriocin> ; # Bacteriocin
    schema:about <http://experiment.worldcat.org/entity/work/data/83064125#Thing/temperature_profile> ; # Temperature profile
    schema:about <http://experiment.worldcat.org/entity/work/data/83064125#Thing/differential_evolution> ; # Differential Evolution
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    schema:contributor <http://experiment.worldcat.org/entity/work/data/83064125#Person/shioya_suteaki> ; # Suteaki Shioya
    schema:contributor <http://experiment.worldcat.org/entity/work/data/83064125#Person/shimizu_hiroshi> ; # Hiroshi Shimizu
    schema:contributor <http://experiment.worldcat.org/entity/work/data/83064125#Person/madlhoo_weeranuch> ; # Weeranuch Madlhoo
    schema:contributor <http://experiment.worldcat.org/entity/work/data/83064125#Person/jariyachavalit_kanidtha> ; # Kanidtha Jariyachavalit
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    schema:datePublished "2005-11-01" ;
    schema:description "The effect of pH and temperature on cell growth and bacteriocin production in Lactococcus lactis C7 was investigated in order to optimize the production of bacteriocin. The study showed that the bacteriocin production was growth-associated, but declined after reaching the maximum titer. The decrease of bacteriocin was caused by a cell-bound protease. Maximum bacteriocin titer was obtained at pH 5.5 and at 22°C. In order to obtain a global optimized solution for production of bacteriocin, the optimal temperature for bacteriocin production was further studied. Mathematical models were developed for cell growth, substrate consumption, lactic acid production and bacteriocin production. A Differential Evolution algorithm was used both to estimate the model parameters from the experimental data and to compute a temperature profile for maximizing the final bacteriocin titer and bacteriocin productivity. This simulation showed that maximum bacteriocin production was obtained at the optimal temperature profile, starting at 30°C and terminating at 22°C, which was validated by experiment. This temperature profile yielded 20% higher maximum bacteriocin productivity than that obtained at a constant temperature of 22°C, although the total amount of bacteriocin obtained was slightly decreased." ;
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