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Applied biopharmaceutics & pharmacokinetics

Author: Leon Shargel; Andrew B C Yu
Publisher: New York : McGraw-Hill Education, [2016]
Edition/Format:   Print book : English : Seventh editionView all editions and formats
Summary:
The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics-now fully updated.
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Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Leon Shargel; Andrew B C Yu
ISBN: 9780071830935 0071830936 9789814670241 9814670243
OCLC Number: 907515796
Description: xvii, 910 pages : illustrations ; 24 cm
Contents: Introduction to biopharmaceutics and pharmacokinetics --
Mathematical fundamentals in pharmacokinetics --
Biostatistics --
One-compartment open model : intravenous bolus administration --
Multicompartment models : intravenous bolus administration --
Intravenous infusion --
Drug elimination, clearance, and renal clearance --
Pharmacokinetics of oral absorption --
Multiple-dosage regimens --
Nonlinear pharmacokinetics --
Physiologic drug distribution and protein binding --
Drug elimination and hepatic clearance --
Pharmacogenetics and drug metabolism --
Physiologic factors related to drug absorption --
Biopharmaceutic considerations in drug product design and in vitro drug product performance --
Drug product performance, in vivo : bioavailability and bioequivalence --
Biopharmaceutical aspects of the active pharmaceutical ingredient and pharmaceutical equivalence --
Impact of biopharmaceutics on drug product quality and clinical efficacy --
Modified-release drug products and drug devices --
Targeted drug delivery systems and biotechnological products --
Relationship between pharmacokinetics and pharmacodynamics --
Application of pharmacokinetics to clinical situations --
Application of pharmacokinetics to specific populations : geriatric, obese, and pediatric patients --
Dose adjustment in renal and hepatic disease --
Empirical models, mechanistic models, statistical moments, and noncompartmental analysis.
Other Titles: Applied biopharmaceutics and pharmacokinetics
Shargel & Yu's Applied biopharmaceutics and pharmacokinetics
Responsibility: editors, Leon Shargel, Andrew B.C. Yu.

Abstract:

The landmark textbook on the theoretical and practical applications of biopharmaceutics and pharmacokinetics-now fully updated  Read more...

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