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Aptamers for Analytical Applications : Affinity Acquisition and Method Design.

Author: Yiyang Dong
Publisher: Newark : John Wiley & Sons, Incorporated, 2018.
Edition/Format:   eBook : Document : EnglishView all editions and formats
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Dong, Yiyang.
Aptamers for Analytical Applications : Affinity Acquisition and Method Design.
Newark : John Wiley & Sons, Incorporated, ©2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Yiyang Dong
ISBN: 9783527806829 3527806822
OCLC Number: 1059418136
Notes: 4.3 Kinetic Characterization.
Description: 1 online resource (429 pages)
Contents: Cover; Title Page; Copyright; Contents; About the Author; Foreword; Preface; Chapter 1 Introduction of SELEX and Important SELEX Variants; 1.1 SELEX; 1.2 Negative SELEX and Its Analogs; 1.3 One-Round SELEX; 1.4 CE-SELEX; 1.5 Microfluidic SELEX; 1.6 Cell-SELEX; 1.7 In Silico-SELEX; 1.8 Post-SELEX and In Chemico-SELEX; 1.9 Auto-SELEX; 1.10 Primer-Free SELEX; 1.11 Genomic SELEX; 1.12 Photo-SELEX; 1.13 qPCR-SELEX; 1.14 Perspectives; References; Chapter 2 In Chemico Modification of Nucleotides for Better Recognition; 2.1 Introduction; 2.1.1 Beyond ATGC; 2.1.2 The Scope of This Chapter. 2.2 Modified Functional Nucleic Acids2.2.1 The "Hows"; 2.2.1.1 Post-SELEX Optimization; 2.2.1.2 In-line Modifications; 2.2.2 The "Whys"; 2.2.2.1 The Hurdles; 2.2.2.2 The Gains; 2.2.3 The "Ifs"; 2.3 Backbone Modifications; 2.3.1 22 OH Modifications; 2.3.2 Phosphodiester Bond Modifications; 2.3.3 Xeno Nucleic Acids; 2.3.3.1 TNA; 2.3.3.2 FANAs; 2.3.3.3 HNA, CeNA, LNA, ANA; 2.3.3.4 Other Modifications; 2.4 Nucleobase Modifications; 2.4.1 General Information; 2.4.2 Modified Aptamers and Catalysts; 2.4.2.1 Introduction of Cationic Moieties; 2.4.2.2 Catalysts with Protein-like Sidechains. 2.4.2.3 Nucleobase-linked Nucleobases2.4.2.4 Glycans Targeting with Boronic Acids; 2.4.2.5 "Click Chemistry"-Based Versatile Approach; 2.4.2.6 Nonenzymatic Selection --
X-aptamers; 2.4.2.7 Slow Off-rate Modified Aptamers; 2.5 Aptamers with Expanded Genetic Alphabet; 2.5.1 GACTZP Aptamers; 2.5.2 Aptamers with a Hydrophobic Fifth Base; 2.6 Summary; References; Chapter 3 Immobilization of Aptamers on Substrates; 3.1 Introduction; 3.2 Methods for Immobilization of Aptamers; 3.2.1 Physical Adsorption; 3.2.2 Covalent Binding. 3.2.2.1 Covalent Immobilization of Activated Aptamers on a Functionalized Surface3.2.2.2 Covalent Immobilization of Modified Aptamers on Activated Surfaces; 3.2.2.3 Covalent Immobilization by Entrapment; 3.2.2.4 Covalent Immobilization by Electrografting; 3.2.3 Self-assembled Monolayers; 3.2.4 Avidin-Biotin Binding (Affinity Coupling); 3.2.5 Electrochemical Adsorption; 3.2.6 Hybridization; 3.3 Immobilization of Aptamers on Substrates for Diagnostic Applications; 3.3.1 Flat Gold; 3.3.1.1 Surface Plasmon Resonance Detection; 3.3.1.2 Electrochemical Detection; 3.3.2 Solid Phase. 3.3.2.1 Optical Detection3.3.2.2 Sample Cleanup; 3.3.3 Nanomaterials; 3.4 Future Perspectives on New Substrates and New Immobilization Chemistries; 3.5 Conclusions; References; Chapter 4 Characterization of Aptamer-Ligand Complexes; 4.1 Introduction; 4.2 Equilibrium Characterization: Thermodynamics; 4.2.1 Basic Principles; 4.2.2 Separation-Based Methods; 4.2.2.1 Equilibrium Dialysis and Related Techniques; 4.2.2.2 High-Performance Liquid Chromatography; 4.2.2.3 Electrophoresis; 4.2.3 Direct Methods; 4.2.3.1 Isothermal Titration Calorimetry; 4.2.3.2 Fluorescence-Based Methods.

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