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Genre/Form: | Thèses et écrits académiques |
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Material Type: | Document, Thesis/dissertation, Internet resource |
Document Type: | Internet Resource, Computer File |
All Authors / Contributors: |
Clément Goubert; Cristina Vieira-Heddi; Matthieu Boulesteix; Frédéric Fleury; Pierre Capy; Frédéric Simard; Josefa Gonzalez; Denis Bourguet; Université Claude Bernard (Lyon).; École Doctorale Evolution Ecosystèmes Microbiologie Modélisation.; Laboratoire de Biométrie et Biologie Evolutive. |
OCLC Number: | 951015032 |
Notes: | Titre provenant de l'écran-titre. |
Description: | 1 online resource |
Responsibility: | Clément Goubert ; sous la direction de Cristina Vieira-Heddi et de Matthieu Boulesteix. |
Abstract:
The Asian tiger mosquito, one of the main vectors of Dengue and Chikungunya, is an invasive species that colonized the world during the last 30 years from its cradle in Asia. Whether this success has an underlying genetic basis remains to be investigated. In order to study the extent of the genetic differentiation between Asian and European populations and the contribution of natural selection to this differentiation, we developed new genetic markers based on transposable elements insertion polymorphism. We first conceived a bioinformatic pipeline -dnaPipeTE-- that allowed to grasp a comprehensive picture of the repetitive fraction of the Tiger's genome through the analysis of a low proportion of raw reads from a ongoing sequencing project. The insertion polymorphism of five transposable element families was then studied by Illumina based transposon display, in 140 individuals from three Vietnamese populations and five European populations. The vast majority of the 128,000 markers showed a very low genetic differentiation between Europe and Asia. However 92 of them displayed extreme frequency differences between the continents. The majority of them segregate at high frequencies in Europe, a pattern suggestive of adaptive evolution towards temperate environments.
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