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Basic Clinical Radiobiology.

Author: Michael C Joiner; Albert J Van der Kogel
Publisher: London : Chapman and Hall/CRC, 2018.
Edition/Format:   eBook : Document : English : 5th edView all editions and formats
Summary:
Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Joiner, Michael C.
Basic Clinical Radiobiology.
London : Chapman and Hall/CRC, ©2018
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Michael C Joiner; Albert J Van der Kogel
ISBN: 9780429955402 0429955405
OCLC Number: 1050727943
Description: 1 online resource (361 pages)
Contents: Cover; Half Title; Title Page; Copyright Page; Contents; Preface; Contributors; 1. Introduction: The significance of radiobiology and radiotherapy for cancer treatment; 2. Irradiation-induced damage and the DNA damage response; 3. Cell death after irradiation: How, when and why cells die; 4. Quantifying cell kill and cell survival; 5. Radiation dose-response relationships; 6. Linear energy transfer and relative biological effectiveness; 7. Physics of radiation therapy for the radiobiologist; 8. Tumour growth and response to radiation; 9. Fractionation: The linear-quadratic approach. 10. The linear-quadratic approach in clinical practice11. Modified fractionation; 12. Time factors in normal tissue responses to irradiation; 13. The dose-rate effect; 14. Pathogenesis of normal tissue side effects; 15. Stem cells in radiotherapy; 16. Normal tissue tolerance and the effect of dose inhomogeneities; 17. The oxygen effect and therapeutic approaches to tumour hypoxia; 18. The tumour microenvironment and cellular hypoxia responses; 19. Combined radiotherapy and chemotherapy; 20. Molecular targeted agents for enhancing tumour response. 21. Biological individualisation of radiotherapy22. Molecular image guided radiotherapy; 23. Retreatment tolerance of normal tissues; 24. Biological response modification of normal tissue reactions: Basic principles and pitfalls; 25. Hadron therapy: The clinical aspects; 26. Tissue response models; 27. Second cancers after radiotherapy; Glossary; Index.

Abstract:

Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

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