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The behavioral neuroscience of drug discrimination

Author: Joseph H Porter; Adam J Prus
Publisher: Cham : Springer, 2018.
Series: Current topics in behavioral neurosciences, 39.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our understanding of these drugs and how these findings translate from animals to humans. The drug discrimination paradigm applies to both drugs of abuse and drugs for treating mental illnesses, and research from these studies has  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Behavioral neuroscience of drug discrimination.
Cham : Springer, 2018
(OCoLC)1044864543
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Joseph H Porter; Adam J Prus
ISBN: 9783319985619 3319985612 9783319985602 3319985604 9783030075071 3030075079
OCLC Number: 1050448389
Description: 1 online resource.
Contents: Intro; Preface; References; Contents; Drug Discrimination: Historical Origins, Important Concepts, and Principles; 1 Introduction; 2 Historical Origins; 2.1 State Dependent Learning; 2.2 Drug Discrimination; 2.3 Two-Lever Operant Drug Discrimination; 3 Important Concepts and Principles of the Drug Discrimination Paradigm; 3.1 A Method to Measure Subjective Effects; 3.2 Classification of Drugs; 3.3 Tolerance and Cross-Tolerance; 3.4 Stereospecificity of Discriminative Stimulus Effects; 3.5 Receptor Mechanisms and Discriminative Stimulus Effects; 3.6 Individual Differences Between Subjects. 3.7 Drug Development4 Summary and Overview of This Volume; References; Discriminative Stimulus Effects of Psychostimulants; 1 Introduction; 2 Discriminative Stimulus Effects of Psychostimulant Drugs; 3 A Note on the Sex of Experimental Subjects; 4 Monoamine Transporter Blocker: Cocaine; 4.1 Dopamine; 4.2 Norepinephrine; 4.3 Serotonin; 4.4 Non-monoaminergic Receptors; 5 Monoamine Transporter Substrate/Releaser: MDMA; 5.1 Stimulant: Hallucinogen Continuum; 5.2 Stereoisomerism; 5.3 Pharmacokinetic Considerations; 5.4 Discriminative Stimulus Effects of MDMA. 6 Monoamine Transporter Substrate/Releaser: d-Amphetamine and Methamphetamine6.1 d-Amphetamine: Prototypical DA Releaser; 6.2 Methamphetamine: Prototypical DA Releaser; 7 Conclusion; References; Discriminative Stimulus Properties of S( --
)-Nicotine: ``A Drug for All Seasons;́́ 1 Introduction; 2 Drug Discrimination; 2.1 Why Use Drug Discrimination (DD) Procedures to Study S( --
)-Nicotine?; 2.2 Rationale; 2.3 Methodology; 2.3.1 Initial Shaping of Behavior; 2.3.2 Training Under Both Drug and Non-drug Conditions; 2.3.3 Testing Procedures; 2.3.4 Challenge Experiments; 2.3.5 Stimulus Generalization. 1.1.3 Serotonin1.2 Nonhuman Primates; 1.3 Humans; 1.4 Neuroanatomical Targets; 1.5 New Paradigm for Advancing Knowledge and Pharmacotherapeutic Development with Ethanol Discriminations; References; Discriminative Stimulus Effects of Abused Inhalants; 1 Introduction; 2 Unique Methodological Aspects of Inhalant Discrimination Studies; 3 Inhalants as Drug Discrimination Training Stimuli; 4 Pharmacological Characterization of Inhalant Discriminative Stimuli; 4.1 Stimulus Effects of Inhalants: GABAA Receptors; 4.2 Stimulus Effects of Inhalants: NMDA Receptors.
Series Title: Current topics in behavioral neurosciences, 39.
Responsibility: Joseph H. Porter, Adam J. Prus, editors.

Abstract:

The goal for this volume is to provide an up-to-date review of the discriminative stimulus properties of major psychoactive drug classes with an emphasis on how this paradigm enhances our  Read more...

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