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Beyond apoptosis : cellular outcomes of cancer therapy

Author: Igor B Roninson; J M Brown; Dale E Bredesen
Publisher: New York : Informa Healthcare, ©2008.
Edition/Format:   Print book : CD for computer   Visual material : EnglishView all editions and formats
Summary:
Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to  Read more...
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Material Type: Internet resource, Videorecording
Document Type: Book, Internet Resource, Visual material
All Authors / Contributors: Igor B Roninson; J M Brown; Dale E Bredesen
ISBN: 9780849391927 084939192X
OCLC Number: 144565832
Description: xi, 352 pages : illustrations ; 24 cm + 1 DVD ROM (4 3/4 in.)
Contents: A personal history of the development of the apoptosis concept / John F.R. Kerr --
What do the clinical data tell us about the role of apoptosis in sensitivity to cancer therapy? / George D. Wilson --
Response of solid tumors to cancer therapy : how relevant is apoptosis? / J. Martin Brown --
Historical studies of various forms of programmed cell death / Richard A. Lockshin and Zahra Zakeri --
Toward a mechanistic taxonomy for programmed cell death pathways / Dale E. Bredesen --
Caspase-independent apoptotic cell death / Lotti Egger --
Autophagic cell death in mammalian cells / David T. Madden --
The cellular decision between apoptosis and autophagy / Yongjun Fan, Erica Ullman, and Wei-Xing Zong --
Parthanatos : PARP and AIF-dependant programmed cell death / Valina L. Dawson and Ted M. Dawson --
Paraptosis / Sabina Sperandio and Ian de Belle --
Cellular senescence and its effects on carcinogenesis / Judith Campisi --
Tumor-suppressing activities of senescent keratinocytes / Brian J. Nickoloff --
Senescence induced by repression of human papillomavirus oncogenes in cervical cancer cells / Daniel DiMaio [and others] --
Treatment-induced tumor cell senescence and its consequences / Igor B. Roninson and Eugenia V. Broude --
Senescence regulation in cancer therapy / Abdelhadi Rebbaa --
Exploiting drug-induced senescence in trasgenic mouse models / Mehtap Kilic and Clemens A. Schmitt --
Therapy-induced cellular senescnece : clinical relevance, implications, and applications / Daniel Y. Wu [and others] --
Mitotic catastrophe in cancer therapy / Eugenia V. Broude [and others] --
How do cells die after irradiation? Time-lapse studies of cells in culture / William C. Dewey --
Modes of cell death by anticancer agents : the crucial importance of dose / J. Martin Brown.
Responsibility: edited by Igor B. Roninson, J. Martin Brown, Dale E. Bredesen.
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Abstract:

Apoptosis, the process of deliberate cell death within a multi-cellular organism, has been linked to both the development and the demise of cancer causing cells. Vast research has been conducted on combating cancer cells through apoptosis in radiation and chemotherapy, however, apoptosis plays only a limited role in determining the success of cancer therapy. This realization has been the catalyst necessary to examine alternative mechanisms for the anti-proliferative action of anticancer agents, as well as moving forward in the complete eradication of cancer. The goal of this book is to examine the relative contribution of apoptosis, and to acquaint the readers with new concepts in non-apoptotic cell death, senescence, and mitotic catastrophe.

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