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Can dendritic cells see light?

Author: Harvard University--MIT Division of Health Sciences and Technology; Hamblin, Michael R.; Hamblin, Michael R.; Hamblin, Michael R.; Chen, Aaron Chih-Hao; Huang, Ying-Ying; Sharma, Sulbha K.
Publisher: Society of Photo-optical Instrumentation Engineers 2010-08-12T19:25:31Z 2010-08-12T19:25:31Z 2010-01
Edition/Format:   Downloadable archival material
Summary:
There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an
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Genre/Form: Article
http://purl.org/eprint/type/JournalArticle
Material Type: Internet resource
Document Type: Internet Resource, Archival Material
All Authors / Contributors: Harvard University--MIT Division of Health Sciences and Technology; Hamblin, Michael R.; Hamblin, Michael R.; Hamblin, Michael R.; Chen, Aaron Chih-Hao; Huang, Ying-Ying; Sharma, Sulbha K.
OCLC Number: 656415952
Language Note: en_US
Notes: application/pdf

Abstract:

There are many reports showing that low-level light/laser therapy (LLLT) can enhance wound healing, upregulate cell proliferation and has anti-apoptotic effects by activating intracellular protective genes. In the field of immune response study, it is not known with any certainty whether light/laser is proinflammatory or anti-inflammatory. Increasingly in recent times dendritic cells have been found to play an important role in inflammation and the immunological response. In this study, we try to look at the impact of low level near infrared light (810-nm) on murine bone-marrow derived dendritic cells. Changes in surface markers, including MHC II, CD80 and CD11c and the secretion of interleukins induced by light may provide additional evidence to reveal the mystery of how light affects the maturation of dendritic cells as well how these light-induced mature dendritic cells would affect the activation of adaptive immune response.

United States National Institutes of Health (Grant R01AI050875)

Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006)

United States Department of Defense. Office of the Congressionally Directed Medical Research Programs (Program in TBI (W81XWH-09-1-0514))

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