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Cancer drug design and discovery

Author: Stephen Neidle
Publisher: London : Academic, ©2008.
Edition/Format:   eBook : Document : EnglishView all editions and formats
The ultimate source of information on the design of new anticancer agents, emphasising small molecules, this newest work covers recent notable successes resulting from the human genome and cancer genomics projects. These advances have provided information on targets involved in specific cancers that are leading to effective medicines for at least some of the common solid tumours. Unique sections explain the basic  Read more...

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Genre/Form: Electronic books
Additional Physical Format: Print version:
Neidle, Stephen.
Cancer drug design and discovery.
London : Academic, 2007
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Stephen Neidle
ISBN: 1281763683 9781281763686 9786611763688 6611763686 0080554954 9780080554952
OCLC Number: 647911335
Language Note: English.
Description: 1 online resource (xv, 473 pages, 28 unnumbered pages of plates) : illustrations
Contents: I. Basic Principles --
Modern cancer drug discovery: Integrating targets, technologies and treatments --
Preclinical pharmacology and in vivo models --
Clinical trial designs for more rapid proof-of-principle and approval --
II. Methodology --
Structural biology and anticancer drug design --
Natural product chemistry and cancer drug discovery --
Pharmacokinetics & ADME optimization in drug discovery --
III. Drugs in the clinic and laboratory --
Temozolomide: from cytotoxic to molecularly-targeted agent --
Camptothecins for drug design, cancer cell death and gene targeting --
Targeting thymidylate synthase by antifolate drugs for the treatment of cancer --
IV. New Agents --
Targeting inactive kinases: structure as a foundation for cancer drug discovery --
Cell cycle inhibitors in cancer: current status and future directions --
Inhibition of DNA repair as a therapeutic target --
Heat shock protein-90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways --
Heat shock protein-90-directed therapeutics and target validation --
Inhibitors of tumour angiogenesis --
The biology and oncology of RAFERK signalling --
P53 as a therapeutic target --
V. The reality of cancer drugs in the clinic --
Cancer drug resistance --
Failure Modes in Anticancer Drug Discovery and Development.
Responsibility: Stephen Neidle.


Presents information on the design of new anticancer agents, emphasising small molecules. This book covers notable successes resulting from the human genome and cancer genomics projects. It provides  Read more...


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