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Genre/Form: | Electronic books |
---|---|
Additional Physical Format: | Print version: Neidle, Stephen. Cancer drug design and discovery. London : Academic, 2007 (OCoLC)154760280 |
Material Type: | Document, Internet resource |
Document Type: | Internet Resource, Computer File |
All Authors / Contributors: |
Stephen Neidle |
ISBN: | 1281763683 9781281763686 9786611763688 6611763686 0080554954 9780080554952 |
OCLC Number: | 647911335 |
Language Note: | English. |
Description: | 1 online resource (xv, 473 pages, 28 unnumbered pages of plates) : illustrations |
Contents: | I. Basic Principles -- Modern cancer drug discovery: Integrating targets, technologies and treatments -- Preclinical pharmacology and in vivo models -- Clinical trial designs for more rapid proof-of-principle and approval -- II. Methodology -- Structural biology and anticancer drug design -- Natural product chemistry and cancer drug discovery -- Pharmacokinetics & ADME optimization in drug discovery -- III. Drugs in the clinic and laboratory -- Temozolomide: from cytotoxic to molecularly-targeted agent -- Camptothecins for drug design, cancer cell death and gene targeting -- Targeting thymidylate synthase by antifolate drugs for the treatment of cancer -- IV. New Agents -- Targeting inactive kinases: structure as a foundation for cancer drug discovery -- Cell cycle inhibitors in cancer: current status and future directions -- Inhibition of DNA repair as a therapeutic target -- Heat shock protein-90 inhibitors: targeting the cancer chaperone for combinatorial blockade of oncogenic pathways -- Heat shock protein-90-directed therapeutics and target validation -- Inhibitors of tumour angiogenesis -- The biology and oncology of RAFERK signalling -- P53 as a therapeutic target -- V. The reality of cancer drugs in the clinic -- Cancer drug resistance -- Failure Modes in Anticancer Drug Discovery and Development. |
Responsibility: | Stephen Neidle. |
Abstract:
Presents information on the design of new anticancer agents, emphasising small molecules. This book covers notable successes resulting from the human genome and cancer genomics projects. It provides a clinical perspective on trials of anticancer agents. It presents drug discovery examples through the use of case histories.
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