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Caractérisation des micro-mécanismes de déformation et de rupture de la paroi d'anévrisme aortique

Author: Cristina CavinatoPierre Badel, biomécanien).Laurent OrgéasBertrand WattrisseSam EvansAll authors
Publisher: 2019.
Dissertation: Thèse de doctorat : Mécanique et Ingénierie : Lyon : 2019.
Edition/Format:   Computer file : Document : Thesis/dissertation : English
Summary:
La paroi de l'aorte thoracique ascendante présente une microstructure complexe et hétérogène qui peut être sujette à la pathologie d'anévrisme, une dilatation irréversible associée à un remodelage dégénératif de la microstructure. Ce dernier entraîne une modification du comportement mécanique du tissu, dont les conséquences les plus graves sont la rupture ou la dissection.L'objectif de cette thèse
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Details

Genre/Form: Thèses et écrits académiques
Material Type: Document, Thesis/dissertation, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Cristina Cavinato; Pierre Badel, biomécanien).; Laurent Orgéas; Bertrand Wattrisse; Sam Evans; Sabine Rolland du Roscoat; Olivier Germain-Thomas; Université de Lyon (2015-....).; École nationale supérieure des mines (Saint-Etienne).
OCLC Number: 1159426270
Notes: Titre provenant de l'écran-titre.
Description: 1 online resource
Responsibility: Cristina Cavinato ; sous la direction de Pierre Badel et de Laurent Orgéas.

Abstract:

La paroi de l'aorte thoracique ascendante présente une microstructure complexe et hétérogène qui peut être sujette à la pathologie d'anévrisme, une dilatation irréversible associée à un remodelage dégénératif de la microstructure. Ce dernier entraîne une modification du comportement mécanique du tissu, dont les conséquences les plus graves sont la rupture ou la dissection.L'objectif de cette thèse est d'aborder l'hypothèse scientifique suivante : les phénomènes qui se produisent au niveau de la structure fibreuse microscopique de collagène et d'élastine sont impliqués ou même responsables de la réponse mécanique macroscopique des anévrismes de l'aorte thoracique ascendante, notamment proche de la rupture. Une méthodologie expérimentale a permis d'allier, en une approche unifiée, un essai mécanique de gonflement ex vivo, un dispositif optique de mesure haute résolution de l'épaisseur des échantillons, un dispositif de corrélation d'images numériques pour la mesure de champs de déplacement, un microscope confocal biphotonique. Des analyses spécifiques aux patients ont été réalisées sur des échantillons d'aorte animale et humaine, en particulier des anévrismes de l'aorte thoracique ascendante humaine, d'un état non chargé jusqu'à rupture. Les relations entre l'état mécanique local et la morphologie microstructurale des composants fibreux de la couche aortique externe, l'adventitia généralement considérée comme la barrière ultime avant rupture, ont été étudiées. Les contributions majeures consistent en des observations des structures fibreuses en réponse au scénario de chargement, jusqu'à rupture, et des liens quantitatifs avec l'état mécanique et les données cliniques.

The wall of the ascending thoracic aorta retains a complex heterogeneous microstructural organization which can be subjected to aneurysms, irreversible dilatations associated with degenerative remodeling processes of the microstructure. The latter results in an altered mechanical behavior of such key tissue whose utmost consequences are rupture or dissection.The following hypothesis is addressed: the phenomena which occur at the microscopic fibrous structure of collagen and elastin are involved or even responsible for the macroscopic mechanical response of ascending thoracic aortic aneurysms, in particular when close to rupture. Towards an improved understanding of the structure-to-mechanics relationship, an experimental methodology enabled the consistent coupling of several test benches: a mechanical inflation test, an optical device for high resolution measurements of the specimen thickness, a image correlation set-up for full-field displacement measurements and a two-photon microscopy bench. Patient-specific analyses were conducted on ex-vivo specimens of animal and human thoracic aortae, in particular human ascending thoracic aortic aneurysms, up to rupture. The analyses focus on the relationship between local mechanical state and microstructural morphology of the principal fibrous components of the outer aortic layer, usually seen as ultimate resistive barrier before rupture. The connection between these data and fundamental information inherent to clinics or morphometry are analyzed. The resulting contribution consists of advanced observations of the fibrous recruitment and reactions to the loading scenario and quantitative links with mechanics and clinics.

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\n\n

Primary Entity<\/h3>\n
<http:\/\/www.worldcat.org\/oclc\/1159426270<\/a>> # Caract\u00E9risation des micro-m\u00E9canismes de d\u00E9formation et de rupture de la paroi d\'an\u00E9vrisme aortique<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:CreativeWork<\/a>, bgn:ComputerFile<\/a>, bgn:Thesis<\/a>, schema:MediaObject<\/a> ;\u00A0\u00A0\u00A0\nbgn:inSupportOf<\/a> \"Th\u00E8se de doctorat : M\u00E9canique et Ing\u00E9nierie : Lyon : 2019.<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:oclcnum<\/a> \"1159426270<\/span>\" ;\u00A0\u00A0\u00A0\nlibrary:placeOfPublication<\/a> <http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/anevrisme_de_l_aorte_ascendante<\/a>> ; # An\u00E9vrisme de l\'aorte ascendante<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/phenomenes_microstructuraux<\/a>> ; # Ph\u00E9nom\u00E8nes microstructuraux<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/reponse_mecanique_locale<\/a>> ; # R\u00E9ponse m\u00E9canique locale<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/anevrisme_de_l_aorte<\/a>> ; # An\u00E9vrisme de l\'aorte<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/rupture<\/a>> ; # Rupture<\/span>\n\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/microstructure_physique<\/a>> ; # Microstructure (physique)<\/span>\n\u00A0\u00A0\u00A0\nschema:author<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/cavinato_cristina_1990<\/a>> ; # Cristina Cavinato<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/orgeas_laurent<\/a>> ; # Laurent Org\u00E9as<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/wattrisse_bertrand<\/a>> ; # Bertrand Wattrisse<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/badel_pierre_1982_biomecanien<\/a>> ; # biom\u00E9canien). Pierre Badel<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/germain_thomas_olivier_1943<\/a>> ; # Olivier Germain-Thomas<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Organization\/ecole_nationale_superieure_des_mines_saint_etienne<\/a>> ; # \u00C9cole nationale sup\u00E9rieure des mines (Saint-Etienne).<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/evans_sam<\/a>> ; # Sam Evans<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Organization\/universite_de_lyon_2015<\/a>> ; # Universit\u00E9 de Lyon (2015-....).<\/span>\n\u00A0\u00A0\u00A0\nschema:contributor<\/a> <http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/rolland_du_roscoat_sabine_1978<\/a>> ; # Sabine Rolland du Roscoat<\/span>\n\u00A0\u00A0\u00A0\nschema:datePublished<\/a> \"2019<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"La paroi de l\'aorte thoracique ascendante pr\u00E9sente une microstructure complexe et h\u00E9t\u00E9rog\u00E8ne qui peut \u00EAtre sujette \u00E0 la pathologie d\'an\u00E9vrisme, une dilatation irr\u00E9versible associ\u00E9e \u00E0 un remodelage d\u00E9g\u00E9n\u00E9ratif de la microstructure. Ce dernier entra\u00EEne une modification du comportement m\u00E9canique du tissu, dont les cons\u00E9quences les plus graves sont la rupture ou la dissection.L\'objectif de cette th\u00E8se est d\'aborder l\'hypoth\u00E8se scientifique suivante : les ph\u00E9nom\u00E8nes qui se produisent au niveau de la structure fibreuse microscopique de collag\u00E8ne et d\'\u00E9lastine sont impliqu\u00E9s ou m\u00EAme responsables de la r\u00E9ponse m\u00E9canique macroscopique des an\u00E9vrismes de l\'aorte thoracique ascendante, notamment proche de la rupture. Une m\u00E9thodologie exp\u00E9rimentale a permis d\'allier, en une approche unifi\u00E9e, un essai m\u00E9canique de gonflement ex vivo, un dispositif optique de mesure haute r\u00E9solution de l\'\u00E9paisseur des \u00E9chantillons, un dispositif de corr\u00E9lation d\'images num\u00E9riques pour la mesure de champs de d\u00E9placement, un microscope confocal biphotonique. Des analyses sp\u00E9cifiques aux patients ont \u00E9t\u00E9 r\u00E9alis\u00E9es sur des \u00E9chantillons d\'aorte animale et humaine, en particulier des an\u00E9vrismes de l\'aorte thoracique ascendante humaine, d\'un \u00E9tat non charg\u00E9 jusqu\'\u00E0 rupture. Les relations entre l\'\u00E9tat m\u00E9canique local et la morphologie microstructurale des composants fibreux de la couche aortique externe, l\'adventitia g\u00E9n\u00E9ralement consid\u00E9r\u00E9e comme la barri\u00E8re ultime avant rupture, ont \u00E9t\u00E9 \u00E9tudi\u00E9es. Les contributions majeures consistent en des observations des structures fibreuses en r\u00E9ponse au sc\u00E9nario de chargement, jusqu\'\u00E0 rupture, et des liens quantitatifs avec l\'\u00E9tat m\u00E9canique et les donn\u00E9es cliniques.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:description<\/a> \"The wall of the ascending thoracic aorta retains a complex heterogeneous microstructural organization which can be subjected to aneurysms, irreversible dilatations associated with degenerative remodeling processes of the microstructure. The latter results in an altered mechanical behavior of such key tissue whose utmost consequences are rupture or dissection.The following hypothesis is addressed: the phenomena which occur at the microscopic fibrous structure of collagen and elastin are involved or even responsible for the macroscopic mechanical response of ascending thoracic aortic aneurysms, in particular when close to rupture. Towards an improved understanding of the structure-to-mechanics relationship, an experimental methodology enabled the consistent coupling of several test benches: a mechanical inflation test, an optical device for high resolution measurements of the specimen thickness, a image correlation set-up for full-field displacement measurements and a two-photon microscopy bench. Patient-specific analyses were conducted on ex-vivo specimens of animal and human thoracic aortae, in particular human ascending thoracic aortic aneurysms, up to rupture. The analyses focus on the relationship between local mechanical state and microstructural morphology of the principal fibrous components of the outer aortic layer, usually seen as ultimate resistive barrier before rupture. The connection between these data and fundamental information inherent to clinics or morphometry are analyzed. The resulting contribution consists of advanced observations of the fibrous recruitment and reactions to the loading scenario and quantitative links with mechanics and clinics.<\/span>\" ;\u00A0\u00A0\u00A0\nschema:exampleOfWork<\/a> <http:\/\/worldcat.org\/entity\/work\/id\/10280829215<\/a>> ;\u00A0\u00A0\u00A0\nschema:genre<\/a> \"Th\u00E8ses et \u00E9crits acad\u00E9miques<\/span>\" ;\u00A0\u00A0\u00A0\nschema:inLanguage<\/a> \"en<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Caract\u00E9risation des micro-m\u00E9canismes de d\u00E9formation et de rupture de la paroi d\'an\u00E9vrisme aortique<\/span>\" ;\u00A0\u00A0\u00A0\nschema:productID<\/a> \"1159426270<\/span>\" ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.theses.fr\/2019LYSEM003\/abes<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <https:\/\/tel.archives-ouvertes.fr\/tel-02868977<\/a>> ;\u00A0\u00A0\u00A0\nschema:url<\/a> <http:\/\/www.theses.fr\/2019LYSEM003\/document<\/a>> ;\u00A0\u00A0\u00A0\nwdrs:describedby<\/a> <http:\/\/www.worldcat.org\/title\/-\/oclc\/1159426270<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Related Entities<\/h3>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Organization\/ecole_nationale_superieure_des_mines_saint_etienne<\/a>> # \u00C9cole nationale sup\u00E9rieure des mines (Saint-Etienne).<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Organization<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"\u00C9cole nationale sup\u00E9rieure des mines (Saint-Etienne).<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Organization\/universite_de_lyon_2015<\/a>> # Universit\u00E9 de Lyon (2015-....).<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Organization<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Universit\u00E9 de Lyon (2015-....).<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/badel_pierre_1982_biomecanien<\/a>> # biom\u00E9canien). Pierre Badel<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1982<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \";<\/span>\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Badel<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Pierre<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"biom\u00E9canien). Pierre Badel<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/cavinato_cristina_1990<\/a>> # Cristina Cavinato<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1990<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Cavinato<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Cristina<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Cristina Cavinato<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/evans_sam<\/a>> # Sam Evans<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Evans<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Sam<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Sam Evans<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/germain_thomas_olivier_1943<\/a>> # Olivier Germain-Thomas<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1943<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Germain-Thomas<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Olivier<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Olivier Germain-Thomas<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/orgeas_laurent<\/a>> # Laurent Org\u00E9as<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Org\u00E9as<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Laurent<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Laurent Org\u00E9as<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/rolland_du_roscoat_sabine_1978<\/a>> # Sabine Rolland du Roscoat<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:birthDate<\/a> \"1978<\/span>\" ;\u00A0\u00A0\u00A0\nschema:deathDate<\/a> \"\" ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Rolland du Roscoat<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Sabine<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Sabine Rolland du Roscoat<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Person\/wattrisse_bertrand<\/a>> # Bertrand Wattrisse<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Person<\/a> ;\u00A0\u00A0\u00A0\nschema:familyName<\/a> \"Wattrisse<\/span>\" ;\u00A0\u00A0\u00A0\nschema:givenName<\/a> \"Bertrand<\/span>\" ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Bertrand Wattrisse<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/anevrisme_de_l_aorte_ascendante<\/a>> # An\u00E9vrisme de l\'aorte ascendante<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"An\u00E9vrisme de l\'aorte ascendante<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/phenomenes_microstructuraux<\/a>> # Ph\u00E9nom\u00E8nes microstructuraux<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Ph\u00E9nom\u00E8nes microstructuraux<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Thing\/reponse_mecanique_locale<\/a>> # R\u00E9ponse m\u00E9canique locale<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Thing<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"R\u00E9ponse m\u00E9canique locale<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/anevrisme_de_l_aorte<\/a>> # An\u00E9vrisme de l\'aorte<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"An\u00E9vrisme de l\'aorte<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/microstructure_physique<\/a>> # Microstructure (physique)<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Microstructure (physique)<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/experiment.worldcat.org\/entity\/work\/data\/10280829215#Topic\/rupture<\/a>> # Rupture<\/span>\n\u00A0\u00A0\u00A0\u00A0a \nschema:Intangible<\/a> ;\u00A0\u00A0\u00A0\nschema:name<\/a> \"Rupture<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/id.loc.gov\/vocabulary\/countries\/fr<\/a>>\u00A0\u00A0\u00A0\u00A0a \nschema:Place<\/a> ;\u00A0\u00A0\u00A0\ndcterms:identifier<\/a> \"fr<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.theses.fr\/2019LYSEM003\/document<\/a>>\u00A0\u00A0\u00A0\nrdfs:comment<\/a> \"Acc\u00E8s au texte int\u00E9gral<\/span>\" ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n
<http:\/\/www.worldcat.org\/title\/-\/oclc\/1159426270<\/a>>\u00A0\u00A0\u00A0\u00A0a \ngenont:InformationResource<\/a>, genont:ContentTypeGenericResource<\/a> ;\u00A0\u00A0\u00A0\nschema:about<\/a> <http:\/\/www.worldcat.org\/oclc\/1159426270<\/a>> ; # Caract\u00E9risation des micro-m\u00E9canismes de d\u00E9formation et de rupture de la paroi d\'an\u00E9vrisme aortique<\/span>\n\u00A0\u00A0\u00A0\nschema:dateModified<\/a> \"2020-06-26<\/span>\" ;\u00A0\u00A0\u00A0\nvoid:inDataset<\/a> <http:\/\/purl.oclc.org\/dataset\/WorldCat<\/a>> ;\u00A0\u00A0\u00A0\u00A0.\n\n\n<\/div>\n\n

Content-negotiable representations<\/p>\n